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Copper Catalysis for Biologically Active N-Heterocycles

dc.authorscopusid 23973608700
dc.contributor.author Menges, N.
dc.date.accessioned 2025-05-10T17:02:27Z
dc.date.available 2025-05-10T17:02:27Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Menges N., Pharmaceutical Chemistry Section, Van Yüzüncü Yil University, Van, Turkey, SAFF Chemical Reagent Research Laboratory, VAN-TEKNOKENT, Van, Turkey en_US
dc.description.abstract N-Heterocycles are essential frameworks, mentioned in countless scientific works, that open a large gate into biologically active compounds; they are mentioned in medicinal chemistry as vital scaffolds. N-Heterocycles can be synthesized via many pathways, especially catalytic reactions that favor green chemistry principles. In catalytic approaches, copper has received special attention from scientists since it is more abundant than other metals, has lower toxicity, and can be handled easily. Copper-catalyzed cyclization reactions serve in many scientific fields, and these reactions resulting in N-heterocycles are of particular interest to the pharmaceutical industry, because many active medicinal ingredients can be synthesized using different copper catalysts. The importance of copper and its support in the synthesis of N-heterocycles was the impetus behind this chapter, and many examples are given of the synthesis of N-heterocycles in which copper catalysts were used. The presence of amine- and phosphine-based ligands for different selectivities, total synthesis using copper, synthesis of pharmaceutical products on gram scale, and biological activities of the mentioned N-heterocycles are all discussed in this chapter. © 2021 Elsevier Inc. All rights reserved. en_US
dc.identifier.doi 10.1016/B978-0-12-821263-9.00013-8
dc.identifier.endpage 477 en_US
dc.identifier.isbn 9780128212639
dc.identifier.scopus 2-s2.0-85125973142
dc.identifier.scopusquality N/A
dc.identifier.startpage 457 en_US
dc.identifier.uri https://doi.org/10.1016/B978-0-12-821263-9.00013-8
dc.identifier.uri https://hdl.handle.net/20.500.14720/5527
dc.identifier.wosquality N/A
dc.institutionauthor Menges, N.
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartof Copper in N-Heterocyclic Chemistry en_US
dc.relation.publicationcategory Kitap Bölümü - Uluslararası en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Click Chemistry en_US
dc.subject Cyclization en_US
dc.subject Drug Candidates en_US
dc.subject N-Heterocycles en_US
dc.subject Phosphine Ligands en_US
dc.title Copper Catalysis for Biologically Active N-Heterocycles en_US
dc.type Book Part en_US

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