Browsing by Author "Aslanoglu, Furgan"

Now showing 1 - 10 of 10

6-Methylthiouracil and 6-Methyluracil Derivatives Synthesized by Reaction of Acetylketene With Thiourea and Urea Compounds in Presence of Yb(Tfa)3
(Taylor & Francis inc, 2023) Aslanoglu, Furgan; Yazici, Ahmet
Thiouracil and uracil derivatives are among the bioactive molecules used in the treatment of many diseases, such as 6-propylthiouracil and 5-fluorouracil. A new synthesis method of 6-methylthiouracil and 6-methyluracil was developed in this study. Various 6-methylthiouracil and 6-methyluracil derivatives were obtained by reacting 2,2,6-trimethyl-4H-1,3-dioxin-4-one with thiourea and urea compounds in the presence of Yb(TFA)(3) according to this new method. Optimization of this new method was performed. The structures of 6-methylthiouracil and 6-methyluracil derivatives were characterized.
Design of 1-(2 Derivatives and Acetoxylation of These Compound's Methylene Via Hypervalent Iodine (Iii)
(Wiley, 2022) Aslanoglu, Furgan
An interesting synthesis method for 2-acetate-1-(2-pyrrolidinone)-butane-1,3-dione compounds was developed in this work. The synthesis of these compounds was carried out in three steps. In the first step, 2-pyrrolidone derivatives were obtained by the Friedel-Crafts reaction in presence of Eaton's reagent. Then, -NH group of 2-pyrrolidone compounds were attached acetoacetate group in presence of 2,6-trimethyl-4H-1,3-dioxin-4-one reagent. Lastly, 1-(2-pyrrolidinone)-butane-1,3-dione derivatives were reacted with Pida to attach acetoxy group to these compound's methylene.
N-Acetylation of Methyl Hydrazones With Acetic Acid in Presence of Pdcl2
(Taylor & Francis inc, 2023) Aslanoglu, Furgan; Sahin, Ertan
Organic compounds such as acetic anhydride or acetyl chloride are generally used to form amide bonds by the acetylation of a nitrogen atom. However, it is not possible to use this traditional method for hydrazine derivatives. In this article, a new synthesis method has been developed for the formation of a new amide bond via the acetylation of methyl hydrazones with acetic acid. In the development of this unprecedented synthesis method, more than one catalyst was used as the Lewis acid. PdCl2 was identified as the most suitable catalyst for this reaction. In addition, more than one solvent experiment was carried out for the optimization of this method and experiments were carried out to provide the most optimal conditions for catalyst loading. In addition, the applicability of this method to various hydrazone derivatives was tested. The structures of nine new amide bond-containing acetylated methyl hydrazones prepared by this synthesis method were elucidated using 1D-NMR, 2D-NMR, LCMS and X-Ray.
Seryum Amonyum Nitrat Varlığında Yeni 3-oksobutanohidrazid Türevlerinin Sentezi
(2022) Aslanoglu, Furgan
Bu çalışmada, yeni 3-oksobutanohidrazid türevleri için yeni bir sentetik yöntem geliştirilmiştir. Bu sentetik yöntem iki adımdan oluşmaktadır. İlk aşamada aldehit fenil hidrazon türevleri sentezlendi. Daha sonra, bu bileşikler 2,2,6-trimetil-4H-1,3-dioksin-4-on (TMD) bileşiği ile katalitik miktarda seryum amonyum nitrat varlığında reaksiyona sokularak hedef moleküller olan 3-okzobutanohidrazit türevleri sentezlendi. Sentezlenen 3-oksobutanohidrazid türevlerinin yapıları 1H-NMR ve 13C-NMR ile karakterize edildi.
A Simple One-Pot Synthesis of 1,2,3,4-Tetrahydro Derivatives
(Wiley, 2008) Akbas, Esvet; Aslanoglu, Furgan; Anil, Baris; Sener, Ahmet
5-Benzoyl-4-(substituted phenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidines (4a-d) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate beta-diketone, arylaldehyde, and thiourea in acetic acid under reflux condition in approximately 52-65% yields. The acetylation of compounds 4a-d gave 3-acetyl thioxopyrimidine derivatives 5a-d. Also, pyrimidothiazine compounds 6a-d were prepared by a simple one-pot condensation reaction of starting pyrimidine derivatives 4a-d and 3-bromopropionic acid. The structures of compounds were characterized on the basis of elemental analyses, IR,H-1 and C-13-NMR spectra.
Studies on Reactions of Pyrimidine Compounds
(Taylor & Francis Ltd, 2007) Aslanoglu, Furgan; Akbas, Esvet; Soenmez, Mehmet; Anil, Baris
The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidin (1) have been prepared via Biginelli cyclocondensation reaction in acetic acid under reflux condition in good yield (93%). Reactions of 1 and iodomethane to afford thiopyrimidine compounds 3 and 5. Also, the acetylation of compounds 1 and 3 gave 3-acetyl thioxopyrimidine 2 and methylthiopyrimidine 4, respectively. Thioxopyrimidine derivative 6 was synthesized from 1 and POCl3/DMF Furthermore, the starting compound 1 were cyclized with various bromo compounds to the thiazolopyrimidine 7, 8, 9 and pyrimido[2,3-b]thiazine10 derivatives, in approximately 55-78% yields. The purpose of synthesizing the thioxopyrimidine derivatives is because of the high biological activities. All of these derivatives have been characterized by analytical and spectroscopic studies and the reaction mechanism is discussed.
Studies on Reactions of Pyrimidine Compounds. 2. Microwave-Assisted Synthesis of 1,2,3,4-Tetrahydro Derivatives
(Taylor & Francis Ltd, 2008) Aklbas, Esvet; Aslanoglu, Furgan
The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (la) and 5-benzoyl-4-(2-chlorophenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (1b) were synthesized using the Biginelli three-component cyclocondensation reaction of a beta-diketone, arylaldehyde, and thiourea under microwave irradiation. Thiazolopyrimidine (2), (3) and pyrimido[2,3-b]thiazine (4) derivatives were obtained by a Simple one-pot condensation reaction of starting compound 1b and 2-bromopropionic acid, bromoacetic acid and 3-bromopropionic acid, respectively. These reactions performed under microwave irradiation and conventional conditions. That study is suggested a simple anal efficient route for the preparation of 1,2,3,4-tetrahydro-2-thioxopyrimidine and derivatives.
Synthesis of 1,3-Oxazepine Derivatives Via Tandem Reaction of 5-Benzylidine Meldrum's Acids With Tosmic in Presence of Potassium Carbonate
(Wiley, 2024) Aslanoglu, Furgan
A new and efficient method for synthesizing 1,3-oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5-benzylidine Meldrum's acid, followed by a 7-endo-cyclization reaction with TosMIC (p-toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.
Synthesis of 2-Methyl Through Reaction of Acetylketene With Terminal Acetylenes in Presence of Gold (I)
(Wiley-v C H verlag Gmbh, 2022) Aslanoglu, Furgan
In this study, 2,6-trimethyl-4H-1,3-dioxin-4-one compound, which is a source of Acetylketene, was reacted with terminal alkynes in presence of IPrAuCl (1,3-Bis(2,6-diisopropylphenyl-imidazol-2-ylidene)gold(I) chloride) catalyst and a new synthesis method for 2-methyl-pyran-4-one compounds has been developed. It was observed that the yields were very low when this reaction was carried out without using a catalyst. However, 95 % yield was obtained when this reaction was performed in the presence of a IPrAuCl catalyst.
Synthesis of Some Transition Metal Complexes of Ligands Derived From 5-Phenyl
(Science Reviews 2000 Ltd, 2008) Akbas, Esvet; Sonmez, Mehmet; Celebi, Metin; Aslanoglu, Furgan
A series of amide ligands was prepared by the reactions of 5-phenyl-2,3-dihydro-2,3-furandione and aromatic amines. The ligands reacted with Cu(II) and Ni(II) ions to yield mononuclear complexes. The ligands and complexes were characterised by elemental analyses, mass, FTIR, UV-vis, (1)H NMR and (13)C NMR spectral studies, as well as magnetic moment, AAS and conductance measurements as appropriate.