Synthesis of 1,3-Oxazepine Derivatives Via Tandem Reaction of 5-Benzylidine Meldrum's Acids With Tosmic in Presence of Potassium Carbonate

Abstract

A new and efficient method for synthesizing 1,3-oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5-benzylidine Meldrum's acid, followed by a 7-endo-cyclization reaction with TosMIC (p-toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.