Synthesis of 2-Methyl Through Reaction of Acetylketene With Terminal Acetylenes in Presence of Gold (I)

Abstract

In this study, 2,6-trimethyl-4H-1,3-dioxin-4-one compound, which is a source of Acetylketene, was reacted with terminal alkynes in presence of IPrAuCl (1,3-Bis(2,6-diisopropylphenyl-imidazol-2-ylidene)gold(I) chloride) catalyst and a new synthesis method for 2-methyl-pyran-4-one compounds has been developed. It was observed that the yields were very low when this reaction was carried out without using a catalyst. However, 95 % yield was obtained when this reaction was performed in the presence of a IPrAuCl catalyst.