Browsing by Author "Aycan, Abdurrahman"

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Change of Antioxidant Enzyme Activities, Some Metals and Lipid Peroxidation in Alzheimer's Disease
(Carbone Editore, 2016) Arslan, Ayse; Tuzun, Fatma Aykan; Tamer, Sibel; Demir, Halit; Aycan, Abdurrahman; Demir, Canan; Gonullu, Edip
Introduction: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive regression and memory loss. It has been claimed that oxidative stress and factors such as metal accumulation in the brain play important roles in the etiopathogenesis of the disease. Material and methods: The subjects of this study consisted of 24 individuals with Alzheimer's disease and 15 healthy agematched controls. Blood samples were withdrawn from the patients and healthy controls, and the activities of antioxidant enzymes SOD (Superoxide Dismutase), GSH (Glutathion), GSHPx (Glutathion peroxidase), GST (Glutathion S-Transferase) and MDA (Malondialdehyde) levels were determined by Spectrometer. Some metals and heavy metals were measured by atomic absorption spectrometry (AAS). Results: Biochemical analyses showed a significant decrease of the main enzymatic antioxidant defences (SOD, GSH, GST and GSHPx) and increased production of lipid peroxidation marker (MDA) in the serum of AD patients, compared to age-matched control group (p< 0.001). Also the levels of Zn, Mg, and Mn was lower and Fe, Pb, and Cd was higher in the patient group, compared to the control group. Serum Cu and Co levels did not differ significantly between the patient and control groups (p> 0.001). Conclusion: These results supports the theory that in AD there is a defect in the antioxidant defense system, which may lead to oxidative damage. Also alterations in some trace metals and their related enzymes may play a role of etiopathogenesis in AD.
Determination of Trace Element Levels in Patients With Burst Fractures
(Turkish Assoc Trauma Emergency Surgery, 2018) Gezh, Shahab Ahmed Salih; Aycan, Abdurrahman; Demir, Halit; Bozlina, Cemal
BACKGROUND: This study aimed to determine trace element levels Zn, Fe, Mn, Mg, Cu, Cd, Co, and Pb in patients with burst fractures in Van Province, Turkey. METHODS: The study included a total of 44 participants with no additional pathologies, including 22 patients with burst fractures aged over 18 years who were admitted to the neurosurgery departments at two hospitals between June 15, 2015 and January 20, 2016 and 22 healthy volunteers. Serum samples were obtained from all participants to measure the serum levels of trace and heavy elements, including Mn, Cd, Cu, Pb, Fe, Co and Zn, using atomic absorbance spectrophotometry. RESULTS: The trace element levels of Zn, Mn, Cu, Co, and Mg were significantly lower (p<0.001), whereas those of Fe, Cd, and Pb were significantly higher in the patient group than in the control group. In addition, the levels of Zn, Mn, Cu, Co, and Mg were lower and the levels of Fe, Cd, and Pb were higher in the patient group than in the control group. CONCLUSION: The probability of burst fracture and its causes leading to any injury may be considered as an indicator balance for the concentration of trace elements between the patient group and control group and may also be a risk factor associated with the bone exposed to burst fracture Significant changes in serum levels of Zn, Cd, Mn, Mg, Pb, Fe, Cu and Zn elements can be observed in patients with burst fractures.
Effects of Low-Intensity Treadmill Exercise on Sciatic Nerve in Experimental Diabetic Neuropathy
(Sci Printers & Publ inc, 2016) Gulsen, Ismail; Demiroglu, Murat; Aycan, Abdurrahman; Uder, Rifki; Alaca, Ilker; Orhon, Zeynep Nur; Kanter, Mehmet
OBJECTIVE: To investigate the potential beneficial effects of low-intensity exercise on histopathological changes of sciatic nerves in streptozotocin (STZ)-induced diabetic rats. STUDY DESIGN: The rats were allotted randomly into 3 experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with low-intensity exercise); each group contained 8 animals. Groups B and C received STZ. Diabetes was induced in 2 groups by a single intraperitoneal injection of STZ (40 mg/kg, freshly dissolved in 0.1 M citrate buffer, pH 4.2). Two days after STZ treatment, diabetes in 2 experimental groups was confirmed by measuring blood glucose levels. Rats with blood glucose levels >= 250 mg/dL were considered to be diabetic. Animals in the exercise group were made to run the treadmill once a day for 4 consecutive weeks. Exercise started 3 days prior to STZ administration. RESULTS: The treatment of low-intensity exercise caused a sharp decrease in the elevated serum glucose and an increase in the lowered serum insulin concentrations in STZ-induced diabetic rats. STZ induced a significant decrease in the area of insulin-immunoreactive beta cells. Low-intensity exercise treatment resulted in increased area of insulin-immunoreactive beta cells signficantly. Myelin breakdown decreased significantly after treatment with low intensity exercise. The ultrastructural features of degenerated axons also showed remarkable improvement. CONCLUSION: We believe that further preclinical research into low-intensity exercise may indicate its usefulness as a potential treatment for peripheral neuropathy in STZ-induced diabetic rats.
The Efficiency of Acoustic Radiation Force Impulse (Arfi) Elastography in the Diagnosis and Staging of Carpal Tunnel Syndrome
(Springer Japan Kk, 2018) Arslan, Harun; Yavuz, Alpaslan; Ilgen, Ferda; Aycan, Abdurrahman; Ozgokce, Mesut; Akdeniz, Huseyin; Batur, Abdussamet
The aim of the present study was to quantify the stiffness of the median nerve (MN) at the carpal tunnel inlet by acoustic radiation force impulse (ARFI) elastography and to evaluate whether ARFI can be used in diagnosis and staging of carpal tunnel syndrome (CTS). Sonographic examinations of 96 wrists in 50 patients were included in the study. The cross-sectional area and stiffness of the MN were quantitatively measured by B-mode ultrasonography (USG) and ARFI. The findings of CTS were assigned to four groups: (I) normal (n = 21), (II) mild (n = 39), (III) moderate (n = 38), and (IV) severe (n = 19). The differences between CTS patients and controls and the differences in electrodiagnostic tests among subgroups were statistically compared. ROC analysis was performed to determine the cut-off values between subgroups. Bilateral CTS was present in 46 patients (92 wrists) and unilateral CTS in four patients. Of the 96 nerves in the 50 symptomatic "idiopathic CTS" patients (48 women, 2 men; mean age 45.9 years, range 23-73 years), 39 (40.4%) were mild, 38 (39.8%) were moderate, and 19 (19.8%) were severely affected. When compared to controls, MN stiffness was significantly higher in the CTS group (P < 0.001); furthermore, it was higher in the severe or extreme severity group than the mild or moderate severity group (P < 0.001). A 3.250 m/s cut-off value on ARFI revealed sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 81, 82, 95.1, 50, and 82%, respectively. The MN stiffness measured by ARFI elastography is significantly higher in patients with CTS then in controls. ARFI elastography appears to be a highly efficient imaging modality for the diagnosis and staging of these patients.
Efficiency of Topical Rifampin on Infection in Open Neural Tube Defects: a Randomized Controlled Trial
(Taylor & Francis Ltd, 2021) Deger, Ibrahim; Basaranoglu, Murat; Demir, Nihat; Aycan, Abdurrahman; Tuncer, Oguz
Objectives Neural tube defects are the second most common congenital malformation in humans. Despite significant decreases in neural tube defects and related mortality and morbidity with recent developments, infections remain an important problem. Research on the role of topical therapy for managing neural tube defects and associated infections in the neonatal period has been limited. This randomized controlled trial aimed to investigate the efficiency of topical Rifampin on infection control in paraplegic newborns with open neural tube defects. Methods Thirty-seven patients who underwent an operation for neural tube defects were included. Topical Rifampin and cefotaxime were administered to 19 patients constituting the case group and local saline and cefotaxime were administered to a control group. Patients were examined for ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, and sepsis. Results None of the patients using topical rifampin had ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, or sepsis. In the control group, ventriculoperitoneal shunt infection/dysfunction was found in 4 (22.2%) cases, surgical site infection in 3 (27.7%), urinary tract infection in 3 (27.7%), and sepsis in 5 (27.7%), with statistically significant differences between the groups (p = 0.01, p = 0.032, p = 0.032, and p = 0.002, respectively). No local or systemic side effect was observed regarding rifampin use. Conclusion Topical Rifampin is effective in minimizing complications like sepsis, surgical site infection, urinary tract infection, and ventriculoperitoneal shunt infection due to neural tube defect operations. Further research with larger numbers of cases is needed to implement this practice routinely.
Evaluation of Cholinergic Enzymes and Selected Biochemical Parameters in the Serum of Patients With a Diagnosis of Acute Subarachnoid Hemorrhage
(de Gruyter Poland Sp Z O O, 2023) Aycan, Abdurrahman; Tas, Abdurrahim; Yeltekin, Asli Cilingir; El-Tekreti, Sama Amer Abbas; Arslan, Ayse; Arslan, Mustafa; Aycan, Nur
Background: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-alpha, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-alpha levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.
Evaluation of Lumbosacral Angle ( Lsa) and Its Impact on Patients With Lumbar Disc Herniation
(derman Medical Publ, 2016) Aycan, Abdurrahman; Guzey, Feyza Karagoz; Ozkan, Nezih
Aim: One of the most common causes of low back pain is lumbar disc herniation (LDH). One of the treatments for patients with LDH is a surgical operation. Changes in the lumbar lordosis angle have a negative impact on patients, clinically. The significance of changes in the lordosis-sacral inclination angle that are associated with muscle spasms and are seen after LDH surgery is known. In this study, we would like to examine the clinical impact on patients due to changes in the lumbosacral angle measured before and after surgical operations in patients with LDH. Material and Method: Between 2005-2007, preoperative and postoperative lumbosacral angles of 139 patients operated on for a diagnosis of lumbar disc herniation were measured. Patients were evaluated with the Oswestry Scale, Visual Analogue Scale, Narcotic Score, and Patient Satisfaction Evaluation. Lumbar lordosis angle, sacral inclination angle, and disc height were calculated by direct radiography. Statistical analysis was performed with GraphPad Prisma V.3 software package. Results: In this study, increases of lordosis angles and sacral inclination angles have been observed, postoperatively. It has been shown that these have a positive impact on the clinical course. Discussion: The clinical effects of the biomechanics of angles of patients with LDH are clear. Biomechanical parameters should be considered at preoperative treatment, postoperative treatment, and postoperative controls. The patient's lordosis angle, neighboring disc structure, and relationship with the sacrum must be carefully evaluated for surgical decision.
Evaluation of Oxidative Stress Levels and Antioxidant Enzyme Activities in Burst Fractures
(int Scientific information, inc, 2018) Kuyumcu, Fetullah; Aycan, Abdurrahman
Background: Spinal burst fractures are pathologies that occur in spinal injuries and cause significant mortality and morbidity as a result. Burst fractures in spinal cord injuries can result in rapid and significant oxidative stress. In addition to the primary injury in severe spinal cord injuries, subsequent secondary lesions are mainly due to inflammatory cascade activation and excessive production of free radicals. This study evaluated oxidative stress and antioxidant enzyme levels in burst fractures. Material/Methods: Twenty patients with burst fractures were diagnosed and underwent surgery and 20 healthy control subjects were included in the study. Neurological status was evaluated using the American Spine Injury Association Impairment Scale (ASIA) before and after surgery. Neurological function was scored as ASIA A: complete deficits, ASIA B-D: incomplete deficits, and ASIA E: neurologically intact. Spectrophotometry was performed to measure malondialdehyde (MDA) and low glutathione (GSH), glutathione peroxidase (GPx) levels, which represent lipid peroxide content. Evaluations were performed within 2 days after injury in the patients. Results: MDA levels were higher in the burst fracture group (p<0.001), whereas GSH and SOD activities were higher in the control group (both p<0.001). There was no statistically significant difference in GPx levels between the groups (p=0.482). Conclusions: Oxidative stress appears to be related to burst fractures. Considering the importance of burst fractures in spinal cord injuries, a better understanding of these mechanisms may help in defining the role of oxidative stress after burst fractures. Prospective, randomized, controlled trials may reveal new therapeutic approaches that include antioxidants for explosive fractures focusing on oxidative stress.
Idiopathic Thoracic Spontaneous Spinal Epidural Hematoma
(Hindawi Ltd, 2016) Aycan, Abdurrahman; Ozdemir, Seymen; Arslan, Harun; Gonullu, Edip; BozkJna, Cemal
A 33-year-old male patient experienced temporary sensory loss and weakness in the right lower extremity one month prior to admission. The patient was admitted to a private clinic with a three-day history of acute onset of sensory loss and weakness in both lower extremities and was treated and followed up with a prediagnosis of transverse myelitis and the Guillain-Barre syndrome (GBS). The patient was subsequently transferred to our clinic and the neurologic examination revealed paraplegia in both lower extremities, positive bilateral Babinski signs, and hypesthesia below the T10 dermatome with saddle anesthesia. The patient had urinary incontinence and thoracic magnetic resonance imaging (MRI) showed an image of a mass compressing the medulla.
Kafa Travması Nedeni ile Ameliyat Edilen 226 Hastanın Retrospektif Değerlendirilmesi: Epidemiyolojik Çalışma
(2015) Arslan, Mehmet; Gulsen, İsmail; Aycan, Abdurrahman; Sösuncu, Enver; Akyol, M Edip
Amaç: Kafa travmaları, özellikle kentlerde ve genç nüfusta en sık görülen morbidite ve mortalite sebeplerinden biridir. Bu retrospektif çalışmayla, kafa travmaları ile ilgili ülkemiz epidemiyolojik veritabanına katkıda bulunmayı amaçladık. Materyal ve Metod: Mayıs 2013-Eylül 2015 tarihleri arasında, Van Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezinde Nöroşirürji kliniğinde tedavi ameliyat edilen 226 hasta retrospektif olarak incelendi. Bulgular: Çalışmaya 185 erkek 41 kadın hasta dahil oldu. Kafa travmasının en sık nedeni düşmeler olarak tesbit edildi. En sık acil ameliyat nedeni travmatik epidural hematom idi. Mortalite oranı %21,3 olarak tespit edildi. Mortalite ile akut subdural hematom arasında anlamlı ilişki varlığı saptandı. Sonuç: Nöroşirurji kliniklerinde travma dışı nedenlerle yapılan acil operasyonlar azımsanamayacak bir oranı oluşturmakta ve çalışmamızda olduğu gibi yüksek mortaliteye katkıda bulunmaktadır
Kraniyosinostozis: Ardışık 15 Vakanın Analizi ve Tedavisi
(2018) Aycan, Abdurrahman
Amaç: Kraniosinostoz, kafatasında bir veya birden fazlasutürün normal sürecinden önce kapanması sonucukafatasında şekil bozukluğu ve nörolojik bozukluklarlaseyreden bir hastalıktır. Çalışmanın amacı Van YüzüncüYıl Üniversitesi Tıp Fakültesi Nöroşirürji AnabilimDalın’da yapılan kraniyosinostoz ameliyatlarının analizi,tanı yöntemleri ve cerrahi tedavi deneyimlerimizipaylaşmaktır.Gereç ve Yöntem: Nöroşirürji kliniğinde 2013-2017tarihleri arasında kraniyosinostoz tanısıyla ameliyat edilençocuk 16 hastanın dosyaları; yaş, cinsiyet, bulgular,kraniyosinoztoz tipleri, uygulananameliyat,komplikasyonlar açısından incelendi.Bulgular: Hastaların 12’i (%75) erkek, 4’ü (%25) kadın,yaş ortalamaları 5,9 (ay) (2-10 ay) idi. Tüm hastalardakafatası şekil bozukluğu belirgin olarak vardı. 13 hastadaçocukta huzursuzluk, uyuyamama, başını etrafa vurma vbbelirtiler mevcuttu. Direkt grafide tanı koyma oranı%70, sütürleri net olarak 3 boyutlu gösteren bilgisayarlıtomografide ise %100 olarak bulundu. Hastaların 9’u(%56.25) izole trigonosefali, 3’ü (%18.75) skafosefali,2’si (%12.5) izole anterior plagiosefali, 1’I (6.25)plagiosefali + trigonosefali, 1'i (6.25) ise posteriorplagiosefali tanısı aldı. Hastaların hepsine cerrahi iletedavi uygulandı. 1 hastada postoperatif pnömoni, 2hastada ise cerrahi sonrası yara yeri enfeksiyonu, 1hastada periorbital yağ dokusu herniasyonu gelişti. Bukomplikasyonlar tedavi edildi. Hastaların hiçbirisindemortalite görülmedi.Sonuç: Kraniyosinostoz yenidoğan çocukluk çağındagörülen nadir bir hastalıktır. Yaşamın erken aylarındacerrahi olarak tedavi edilmediği taktirde anormal kafayapısı ile çocukların psişik ve sosyal gelişimini olumsuzetkiler. Kafatasında şekil bozukluğu ve fontanellerinerken kapanması kraniyosinostoz hastalığınıdüşündürmelidir. Üç boyutlu Bilgisayarlı tomografi tanıdaaltın standarttır. Öncelikli tedavi cerrahidir.
L4-l5 Seviyesinde Kafes ve Otogreftle Yapılan İnterbody Füzyonunun Tek Başına Otogreftle Yapılan Füzyonla Morfometrik Karşılaştırılması
(2023) Tufan, Azmi; Guzey, Feyza Karagoz; Aycan, Abdurrahman
Amaç: Lomber interbody füzyon (LIF), diskektomi yapıldıktan sonra intervertebral boşluğa bir kafesle veya kafes olmaksızın kemik greft yerleştirilmesi işlemidir. Literatürde kafesli LIF yöntemlerini karşılaştıran birçok çalışma vardır. Buna rağmen kafesli ve kafessiz LIF yöntemlerini karşılaştıran çalışma çok azdır. Bu çalışmada peek kafesli ve kafessiz laminar otogreft kullanılarak yapılan interbody füzyonun geç dönem sonuçlarının karşılaştırılması amaçlanmıştır. Çalışma spesifik olarak L4-5 seviyesinde yapılmıştır. Yöntem: Bu retrospektif karşılaştırmalı çalışma 2011-2018 yılları arasında kurumumuz nöroşirurji kliniğinde opere edilen hastalar üzerinde aynı kurumdan etik kurul onayı alınarak yapılmıştır. L4-5 tek seviyeli lomber enstrümantasyon uygulanıp füzyon amacıyla otogreftle birlikte muz kafes kullanılarak transforaminal LIF operasyonu yapılan hastalar çalışma grubunu (Grup 1, n=27), sadece otogreft ile arka LIF operasyonu yapılan olgular kontrol grubunu oluşturdu (Grup 2, n=31). Otogreft olarak dekompresyon esnasında posterior yapılardan elde edilen kortikokanselloz kemik parçaları kullanıldı. Füzyon oranları, segmental ve lomber lordoz açısı, disk yüksekliği, ipsilateral ve kontralateral foramen yüksekliği ve kayma mesafesi ölçüldü. Bulgular: Yaptığımız çalışmada kafesli ve kafessiz gruplarda geç dönem füzyon oranları sırasıyla %96,3 ve %96,7 olarak bulundu. Segmental ve lomber lordozda iki grupta da değişiklik olmadı. Kafesli grupta geç dönem kafes gömülmesi, kafessiz grupta ise greft göçü en sık komplikasyonlardı. Sonuç: Hem kafesli hem de kafessiz LIF yüksek füzyon oranları olan cerrahi tekniklerdir. Füzyon açısından otogreft grubu, dizilim açısından ise kafesli grubun sınırlı bazı avantajları vardır. Kafessiz otogreftle LIF basit, sade ve düşük maliyet gibi özellikleriyle yeterince takdir edilmeyen bir cerrahi teknik olarak görünmektedir.
The Levels of Trace Elements and Heavy Metals in Patients With Acute Migraine Headache
(Pakistan Medical Assoc, 2015) Gonullu, Hayriye; Gonullu, Edip; Karadas, Sevdegul; Arslan, Mehmet; Kalemci, Orhan; Aycan, Abdurrahman; Demir, Halit
Objective: To compare the levels of trace elements and heavy metal in patients with acute migraine and healthy controls. Methods: The prospective study was conducted at Yuzuncu Yil University, Turkey, from May to July 2013, and comprised migraine patients and an equal number of healthy controls. International Headache Society classification was used for diagnosing migraine. Serum copper, zinc, lead, iron, cadmium, cobalt, manganese, and magnesium levels were measured in both groups. Metal concentrations were assessed by atomic absorption spectrophotometry. SPSS 13 was used for statistical analysis. Results: There were 25 migraine patients with an average age of 36.4+/-8.9 years and 25 healthy controls with a mean age of 42.4+/-9.5 years. Cadmium, iron, manganese and lead levels were significantly elevated in the patients compared to the controls (p<0.05 each), while copper, magnesium and zinc were decreased and cobalt demonstrated no change. Conclusions: Trace elements and heavy metals may have a role in the genesis of considerable oxidative stress in patients with acute migraine headache.
Morphometric Variations of Superior Temporal Sulcus
(2024) Cıkla, Ulas; Aycan, Abdurrahman
Aim: This study focuses on the Superior Temporal Sulcus (STS), a crucial structure in the brain that delineates the anatomical boundary between the superior and medial temporal gyri. The STS is significant in social cognition, particularly in tasks involving cognitive empathy and perspective- taking. Understanding its anatomical relationship with superficial skull landmarks is vital for cranial surgery and surgical planning. Materials and Methods: The study involved an in-depth examination of the STS in sixteen adult human brains, totaling 32 hemispheres. The research included detailed measurements of sulcal lengths, assessments of sulcal depths, and observations of segment and branch variations within the STS. Results: The continuous pattern was observed in 28.6% (4 cases) of the left hemisphere and 71.4% (10 cases) in the right hemisphere. The interrupted pattern was identified in 55.6% (5 cases) of the left hemisphere and 44.4% (4 cases) in the right hemisphere. The temporal pole pattern was present in 77.8% (7 cases) of the left hemisphere and 22.2% (2 cases) in the right hemisphere. The number of segments in STS showed significant variation across these pattern types, with a p- value of 0.0001, indicating statistical significance. Conclusion: A comprehensive understanding of the STS’s anatomy is essential for neurosurgeons as it serves as a critical guide in navigating cerebral pathologies.The anatomical and cadaveric studies substantially deepen our comprehension of the STS’s structural variations, thereby enriching the field’s knowledge base and potentially facilitating the refinement of neurosurgical planning processes.This research highlights the critical significance of the STS within clinical and neuroscientific frameworks, particularly its vital contribution to neurosurgical procedures.
Neurosurgical Injuries Caused by the 2011 Van Earthquake: the Experience at the Van Regional Training and Research Hospital
(Elsevier Science inc, 2015) Aycan, Abdurrahman; Yener, Ulas; Aycan, Nur; Gonullu, Edip; Dursun, Recep; Gonullu, Hayriye
Background: On October 23, 2011, a devastating earthquake, magnitude 7.2 on the Richter Scale, jolted the province of Van in the east of Turkey and led to hundreds of casualties. Objectives: In this study, we aimed to present our clinical experience in the management of patients with cranial and spinal injuries who were admitted to the Van Regional Training and Research Hospital. Methods: The retrospective study included 44 (77.2%) patients who were referred to the neurosurgery department after being diagnosed with spinal and cranial injuries due to earthquake at the emergency department between October 23 and 27, 2011. Results: The patients comprised 32 male (72.7%) and 12 (27.3%) female patients with a mean age of 23.5 years. The injuries included scalp injury (n=16), burst fracture (n=7), compression fracture (n=3), epidural hematoma (n=9), subdural hematoma (n=3), contusion (n=1), traumatic subarachnoid hemorrhage (n=2), depressed skull fracture (n=3), linear fracture (n=9), cervical fracture (n=2), and pneumocephalus (n=1). Most of the patients (90.9%) had isolated injuries and the others (9.1%) presented with combined cranial and spinal injuries. At discharge, the 3 patients with spinal fractures were paraplegic, and of the 2 patients who were operatively treated due to subdural hematoma, 1 was hemiparesic and the other was hemiplegic. No mortality occurred in our patients. Conclusions: The results of this study demonstrated that, in the aftermath of a natural disaster, conducting correct triage procedures and performing a prompt intervention with appropriate and qualified equipment play key roles in reducing morbidity and mortality. (C) 2015 Elsevier Inc.
A New Approach in the Treatment of Traumatic Brain Injury: the Effects of Levosimendan on Necrosis, Apoptosis, and Oxidative Stress
(Elsevier Science inc, 2022) Aycan, Abdurrahman; Oksuz, Ersoy; Gonullu, Edip; Kume, Tuncay; Ergur, Bekir; Akyol, Mehmet Edip; Kuyumcu, Fetullah
- OBJECTIVE: Traumatic brain injury (TBI) is an essential and common health problem worldwide. Levosimendan is an inotropic and vasodilator drug used to treat heart failure. Moreover, it exerts pleiotropic effects and, thus, protective effects on many organs. The present study aimed to investigate the effect of levosimendan on necrosis, apoptosis, and reactive oxygen species in rats with TBI. - METHODS: The study included 28 female Wistar-Albino rats weighing 200-250 g. The rats were divided into 4 groups with 7 rats each as follows: Group 1: No trauma group (Control), Group 2: Traumatized, untreated group (T), Group 3: Levosimendan was administered at a dose of 12 mg/kg intraperitoneally 1 hour after the trauma (L1), Group 4: Levosimendan was administered at a dose of 12 mg/kg intraperitoneally 2 hours after the concussion (L2). After the experiment, the rats were decapitated, and the brain tissue was removed. Necrosis was assessed with Cresyl violet staining, apoptosis was assessed with immunohistochemical analysis, superoxide dismutase and catalase levels were measured with the spectrophotometric method, and malondialdehyde (MDA) levels were assessed by High-Performance Liquid Chromatography. - RESULTS: The number of necrotic cells in the L1 and L2 groups was significantly lower than in the K and T groups (P = 0.015 and P = 0.03, respectively). Although the active caspase-3 level was signified considerably in the T, L1, and L2 groups compared to the K group, no significant difference was found among these 3 groups (P > 0.05). The results of superoxide dismutase levels were similar to those of active caspase-3. catalase level was significantly higher in the K group than in the T and L2 groups (P = 0.045). Malondialdehyde activity was considerably higher in the L1 and L2 groups compared to the K group (P = 0.023). - CONCLUSIONS: Our results indicated that levosimendan may exert a neuroprotective effect by reducing necrosis in TBI and that levosimendan does not affect apoptosis and antioxidant levels in TBI. Comprehensive studies are needed to elucidate the effect of levosimendan on TBI fully.
A New Approach in the Treatment of Traumatic Brain Injury: the Effects of Levosimendan on Necrosis, Apoptosis, and Oxidative Stress (Vol 168, Pg E432, 2022)
(Elsevier Science inc, 2023) Aycan, Abdurrahman; Oksuz, Ersoy; Gonullu, Edip; Kume, Tuncay; Ergur, Bekir; Akyol, Mehmet Edip; Kuyumcu, Fetullah
Paraplegia Caused by Thoracic Fracture Dislocation in a Young Patient and Management: Case Report
(Elsevier Science inc, 2016) Aycan, Abdurrahman; Arslan, Harun; Batur, Abdussamet; Ozgokce, Mesut; Bora, Aydin; Yavuz, Alpaslan
Port Kateterizasyonu: 156 Hastalık Klinik Deneyimimiz
(2021) Yesıltas, Serdar; Aycan, Abdurrahman; Dogan, Erkan; Gönüllü, Edip; Koca, Dogan
Amaç: Ülkemizde pratikte çeşitli klinik ve cerrahi branşlar tarafından uygulanabilen port kateterizasyonu, malignite hastaları başta olmak üzere uzun süreli parenteral tedavi gerektiren hasta gruplarında son derece konforlu bir işlemdir. Yöntem: Bu çalışmada yerel etik kurul onayı alındıktan sonra anestezi uzmanı tarafından port kateterizasyon uygulanmış olan 156 hasta retrospektif olarak değerlendirildi. Bulgular: Hastaların %98,1’ine malignite (özofagus Ca: %37,3, mide: %24,8) nedeni ile işlem uygulandı. En sık uygulama yeri sağ internal juguler vendi (%65,4). Altmış iki hastada 2 veya daha fazla ponksiyon gerekti. Hastaların %1,9’unda port cebi enfeksiyonu nedeni ile port çıkarıldı. Sonuç: Biz bu çalışmada port kateterizasyon deneyimimizi sunduk ve ulusal literatüre katkı sunmayı amaçladık.
Posterior Reversible Encephalopathy Syndrome in Iga Vasculitis: Neuroimaging of a 14-Year Child
(Elsevier Urban & Partner Sp Z O O, 2018) Arslan, Harun; Yavuz, Alpaslan; Arslan, Ayse; Aycan, Abdurrahman
IgA vasculitis (IgAV) is a leukocytoclastic vasculitis and characterized by involvement of small vessels in skin, gastrointestinal system, joints, kidneys, and less frequently other organs. It is the commonest vasculitis in childhood and etiology is not completely known. Neurological manifestations of IgAV are very rare and usually seen in patients with severe hypertension or as an uncommon feature such as peripheral neuropathy. Posterior reversible encephalopathy syndrome (PRES) is a clinic-radiologic entity characterized with temporary vasogenic edema developing typically in posterior circulation of the brain and has been reported as a rare manifestation of IgAV. In this paper, a PRES case of 14-year-old male with IgAV is reported and etiopathogenesis was discussed with literature. Diagnosis was made by magnetic resonance imaging because of the existence of neurological symptoms (headache and visual loss) during the course of disease. His radiological findings have resolved with therapy. Although neurological involvement is a rare manifestation in IgAV, we recommend magnetic resonance imaging in such patients for diagnosis and evaluation of complications. (c) 2017 Published by Elsevier Sp. z o.o. on behalf of Polish Neurological Society.