Browsing by Author "Denizhan, V."

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Enhancement of the Glucose Metabolism and the Reverse Cholesterol Transport by a Peroxisome Proliferator Receptor Α (Pparα) Agonist Included in the Fasciolosis Treatment in Naturally Infested Sheep
(Ecole Nationale veterinaire Toulouse, 2013) Yuksek, N.; Altug, N.; Denizhan, V.; Ceylan, E.; Agaoglu, Z.
The purpose of this study was to investigate the effects of PPAR alpha agonist on metabolic parameters in naturally Fasciola-infected sheep. Twenty sheep with fasciolosis were allotted in 2 equal groups according to the received treatment (triclabendazole/levamisole in the group I and triclabendazole/levamisole + PPAR alpha agonist (2-methyl-2-phenoxy-propionic acid) in the group II) and the haematological and biochemical parameters were assessed before the treatment and 7, 14 and 28 days after and were compared to control values determined from 10 healthy sheep. As expected, fasciolosis has induced an anaemia evidenced by low haematocrit and low haemoglobinemia coupled to eosinophilia and to a moderate lymphopenia, severe liver damage characterised by hepatocyte degenerescence (significant increases in serum AST and GDH activities) and bile duct obstruction (significant increases in serum GGT activity and in serum bile acid concentrations) leading to impairement in liver metabolic functions (hypoalbuminemia, marked decreases in serum glucose concentrations and in LDL associated cholesterol concentrations). All the heamatological and biochemical alterations were at least partially alleviated by the antihelminthic treatment except the serum triglyceride concentrations which have continued to decrease during the post-treatment period and the total cholesterol and HDL associated cholesterol concentrations which have markedly increased, particularly when sheep were also treated with the PPAR alpha agonist. These results clearly demonstrated the severe metabolic liver impairment occurring during fasciolosis in sheep and the beneficial effects of the PPAR alpha agonist on the correction of the negative energy balance, particularly by promoting the reverse cholesterol transport.
Evaluation of Cobalt, Vitamin B12 and Homocystein Levels in Cattle Infected With Theileria Annulata
(Journal Livestock Science, 2017) Denizhan, V.; Kozat, S.; Ozkan, C.
This study was conducted to assess the pattern of changes and the relative values of homocysteine in bovine tropical theileriosis. The diseased group comprised of 20 cattle (2-3 years old) naturally infected with Theileria annulata. As control group, 10 uninfected cattle were also sampled. Whilecobalt (Co), vitamin B-12, folate, total protein (TP), globulin values were determined significantly lower than control group (P<0.001), serum homocystein (Hcy), creatine kinasemyocardial band (CK-MB), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), creatinine, urea, and blood urea nitrogen (BUN) concentrations were determined higher than control group (P<0.001). As a result, decreases in serum B-12 vitamin concentrations of cattle with theileriosis lead to increases in serum Hcy level.
Evaluation of Serum Cobalt, Copper, Iron, Calcium, Phosphorus and Magnesium Concentrations in Cattle Naturally Infected With Theileria Annulata
(Ataturk Universitesi, 2017) Denizhan, V.; Kozat, S.; Özkan, C.; Tuncer, S.S.
The purpose of this study was to evaluate serum albumin, glucose, calcium (Ca), cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), and phosphorus (P) in cows with naturally infected with Theileria annulata. The material of this study was a total of 15 cattle with different ages, breeds and genders diagnosed as theileriosis according to clinical and microscopical examination. According to statistical analyses of biochemical parameters; serum glucose, Ca, Co, Cu, Fe, Mg, and P concentrations were detected significantly low in cattle with theileriosis (P<0.001). In conclusion; mineral substance levels were altered in cattle naturally infected with Theileria annulata. Additionally to the classical treatment of theileriosis, administering mineral supplements including Ca, Co, Fe, Cu, Mg, and P to the animals is thought to be more useful in treatment.
Evaluation of Serum Homocysteine and Nitric Oxide Concentrations Compared With Other Biochemical Parameters in Sheep Naturally Infected With Fasciola Hepatica
(Hellenic Veterinary Medical Society, 2020) Denizhan, V.; Kozat, S.
This study aims to determine the changes in serum homocysteine (Hcy) and nitric oxide (NO) concentrations in sheep naturally infected with F. hepatica. The animal material of the study consisted of a total of 50 sheep: 40 sheep with fascioliasis and 10 healthy sheep. The statistical analysis indicated that serum homocysteine concentrations, folate and vitamin B12 levels of the sheep infected with F. hepatica were higher than those of the control group (P<0.001 P<0.001 and P<0.05, respectively), whereas the nitric oxide levels of the sheep infected with F. hepatica were significantly lower than those of healthy sheep (P<0.001). In conclusion, it is thought that vitamin B12 and folate are not used sufficiently for the conversion of homocysteine to methionine in the remethylation cycle due to the damage in the liver tissue of sheep naturally infected with F. hepatica. This results in the increase of homocysteine which in turn inhibits the formation of nitric oxide. © 2020 V. DENIZHAN, S. KOZAT.
Investigation of Serum Amyloid A, Haptoglobin and Fibrinogen Levels in Sheep Infected With Fasciola Hepatica
(Journal Livestock Science, 2019) Denizhan, V.; Kozat, S.; Yilmaz, A. B.
The present study aimed to determine the changes in serum haptoglobin, serum amyloid A and fibrinogen levels in pathological disorders of sheep liver with Fasciola hepatica. Sixty sheep (50 with fascioliasis and 10 healthy) were used in the present study. Statistical analysis results demonstrated that SAA, Hp and fibrinogen concentration levels of the sheep infected with Fasciola hepatica were higher when compared to SAA, Hp and fibrinogen concentration levels in healthy sheep (P <0.05). While ALT, AST and GGT values of sheep infected with Fasciola hepatica were found to be higher than those of the healthy sheep, serum TP, ALB and glucose levels were lower. In statistical analysis, it was found that WBC, Neu and Eo values of sheep infected with Fasciola hepatica were higher when compared to WBC, Neu and Eo values in the control group. In conclusion, serum haptoglobin, serum amyloid A, and fibrinogen levels were significantly higher in sheep infected with Fasciola hepatica when compared to the healthy group. Due to the fact that increases in serum haptoglobin, serum amyloid A and fibrinogen levels in sheep with fasciolosis were similar to those observed in liver disorders, it was suggested that these parameters could be useful in determination of the liver damage levels and prognosis and in studies on liver disorders.
The Prevalence of Linguatula Serrata (Fröhlich, 1789) Nymphs in Sheep in the Van Province
(2009) Gül, A.; Deǧer, S.; Denizhan, V.
This research was carried out in order to detect the prevalence of Linguatula serrata nymphs in lung and mesenteric lymph nodes of sheep in Van province. For this purpose, mesenteric lymph nodes of 347 sheep and lung lymph nodes of 224 sheep were examined. L. serrata nymphs were found in 18 (5.19%) out of 347 sheep. L. serrata nymphs were not found in the lung lymph nodes of 224 sheep. In infected sheep, a total of 19 L. serrata nymphs were collected and two nymphs of L. serrata were seen in one mesenteric lymph node.
Seroprevalence of Fasciola Hepatica in Sheep in the Province of Van and Some Districts
(Ataturk Universitesi, 2018) Denizhan, V.; Biçek, K.
This study was carried out on 352 sheep 110 of which is below the age of 2, 171 is between 2-6 and 71 is above the age of 6 to determine the prevalence of fasciolosis caused by Fasciola hepatica in sheep in the centre of Van and its districs Özalp, Saray, Gevaş and Gürpinar between January and December 2009. All feces and blood samples were examined in the point of the eggs of parasite in feces and specific antibodies, respectively by Benedek sedimentation and antibody ELISA techniques. The origin of sheep, date of sample collection, age and sex of the sheep were recorded. In the research areas, the coprological prevalence and seroprevalence of fasciolasis in sheep were determined as 15.63 % and 49.43%, respectively. In the infected sheep, Fasciola hepatica were found by benedek sendimentation. The highest prevalence seroprevalence of Fasciolosis was observed among the sheep above age of 6 (83.9 %) and followed by 2-6 age group (46.19%) and <2 age group of sheep (36.32%). In the point of statistics, the difference between the age groups was significant (According to Chi-Square testing P<0.001). The seroprevalence of fasciolasis was %50.35 among females and %45.71 among males which was not accepted as a remarkable difference (P>0.001). As a result Fasciola hepatica was commonly detected in sheep in Van province. Epidemiology and control of this parasitic infections in the region for further studies are needed. © Ataturk Universitesi. All rights reserved.
Serum Adenoslne Deaminase Activity and Biochemical Parameters in Chronic Fascioliasis in Sheep
(2006) Kozat, S.; Ekin, S.; Kaya, A.; Denizhan, V.