Browsing by Author "Emre, Habib"

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Ani Şuur Kaybı Ile Gelen Fahr Sendromu Consciousness
(2010) Ulvi, Hızır; Demir, Recep; Emre, Habib; Tamer, A. Furkan
Fahr sendromu; bazal ganglionların simetrik kalsifikasyonuyla seyreden klinik durumdur. Hastalığın ilişkili olduğu birçok durum olmasına rağmen etiyolojisi halen bilinmemektedir. Sendromun klinik özellikleri değişken olup sıklıkla nöropsikiyatrik, ekstrapiramidal, serebellar semptomlar mevcuttur. Ayrıca nadir olarak koma da görülebilir. 59 yaşında erkek hasta acil polikliniğine ani şuur bozukluğu şikayeti ile getirildi. Anamnezinde daha önce 2 kez generalize tonik klonik nöbet geçirme dışında özellik yoktu. Hastanın nörolojik muayenesinde; şuuru kapalı, oryantasyon ve kooperasyon kurulamıyor, ışık ve kornea refleksi alınıyor, pupiller izokorik, patolojik refleksi ve taraf bulgusu yoktu. Glasgow koma skoru; 4, ağrılı uyarana deserebre postürle cevap vardı. Hasta acil serviste çekilen beyin tomografisinde (BT) dansite ölçümü yapılmadığı için bazal gangliyonlarda ki bilateral simetrik hiperdens lezyon, klinik akut geliştiği için intraserebral hemoraji düşünülerek hospitalize edildi. Hastanın kalsiyumu 2.64 mg/dl olarak tesbit edildi. Kalsiyum replasmanı sonrası kliniği dramatik olarak düzeldi. BT'deki radyolojik bulgular bilateral kalsifikasyon olarak değerlendirilerek intraserebral hemoraji tanısından uzaklaşıldı. Sonuç olarak; ani şuur kaybı ile gelen,BT’deki kalsifik lezyon dansite ölçülmedği için intraserebral hemoroji düşünülen, generalize tonik klonik nöbetlerinin sebebi geç fark edilen atipik seyirli bir Fahr sendromu olgusunu sunduk.
The Assessment of the Diet Knowledge Level and Daily Dietary Practice of the Relatives of Hemodialysis Patients
(Drunpp-sarajevo, 2012) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Erdur, Mehmet Fatih; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objectives: In this study, we aimed to investigate the level of nutrition and diet knowledge and the daily dietary practices of the relatives of hemodialysis patients. Material and Methods: We recruited 39 relatives whose patients receiving hemodialysis, and who provided the patient's dietary needs. The questionnaire containing questions regarding daily salt, water, potassium and phosphate intakes was conducted to the patient's relatives. The questionnaire results were reflected to the graphics with numbers and percentages. Results: The patient's relatives had sufficient information about the salt and water intakes, but they were not very sensitive to use their dietary knowledge during their daily practice. The relatives did not have enough information about the foods which containing phosphate and potassium and the clinical situations/complications related to the phosphor and potassium. Conclusions: The nutrition and diet education should be also provided to the patients' relatives. Besides the education, the patients and the relatives should be followed up periodically to see if they apply their knowledge. The relatives especially should be instructed about foods containing salt, phosphate and potassium.
Azigos Vein: Is It a Malposition or an Alternative
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2011) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Demirkiran, Davut; Erdur, Fatih Mehmet; Gumrukcuoglu, Hasan Ali; Erkoc, Reha
Use of a temporary central venous catheter is common practice in hemodialysis therapy. One of the most common complications of central venous catheterization is catheter malposition. Cannulation of the azygos vein (particularly the azygos arch) is a rare but hazardous catheter malposition that carries a substantial risk of perforation, thrombosis and vascular stenosis. On the other hand, the azygos vein can be used for vascular access in patients whose superior vena cava and inferior vena cava are thrombosed. We present a case where the required blood flow for hemodialysis was provided by a dilated azygos vein due to superior vena cava obstruction.
Combined Immune Thrombocytopenic Purpura and Immunoglobulin a Nephropathy: a Similar Pathophysiologic Process
(informa Healthcare, 2014) Kahraman, Cuneyt; Emre, Habib; Gulcan, Erim; Bilen, Yusuf; Uludag, Koray; Uyanik, Abdullah; Keles, Mustafa
IgA nephropathy is one of the most common forms of glomerulopathies. It is an immune complex-mediated glomerulonephritis diagnosed by the presence of mesangial IgA deposits that are often associated with mesangial cell proliferation. The IgG, C-3, IgM, or other immunoglobulin light chains may be co-existed with IgA. Its pathogenesis suggested that it is responsible for enhancing the production of proinflammatory cytokines, chemokines, and growth factors. Platelet-derived growth factor (PDGF) has also been implicated as a modulator of disease activity. Immune thrombocytopenic purpura (ITP) is a bleeding disorder caused by thrombocytopenia that is not associated with a systemic disease. Its pathogenesis suggested an autoimmune disease in which IgG is thought to damage megakaryocytes, which are the precursors of platelet cells. Several studies reported that PDGF levels were higher in normal subjects than in patients with ITP. Moreover, ITP is a disease related to the antibody. Thus, our aim is to examine whether a similar pathophysiological relationship exist between ITP and IgAN that may be mediated by PDGF and/or IgG.
Comparison of the Automated Cell Counter and Manual Method for the Assessment of Dialysis Fluids in Peritoneal Dialysis Patients
(Drunpp-sarajevo, 2011) Soyoral, Yasemin Usul; Begenik, Huseyin; Aldemir, Mehmet Naci; Baran, Ali Irfan; Emre, Habib; Karahocagil, Mustafa Kasum; Erkoc, Reha
Objective: To compare the accuracy of automated cell counter and the manual methods for the peritoneal fluid assessments in peritoneal dialysis patients. Material and Method: We analyzed 72 peritoneal fluid samples collected under sterile conditions from 27 patients with peritonitis (15 female; 12 male) following by the peritoneal dialysis unit of Yuzuncu Yil University Medical Faculty. The white blood cell counts of these peritoneal fluid samples were assessed by the both manual method and the automated cell counter. Results: The white blood cells were usually higher in the automated cell count method than the manual method (p<0,01). In 5 subjects, white cell counts were less than 100 cell/mu L in the manual method, but were more than 100 cell/mu L in the automated counter. There was a significant correlation between the manual and automated methods in terms of cell counts (p<0.01, r = 0.79). We also found good correlation between the two methods when WBC counts were greater than 300 cell/mu L (r = 0.87). Conclusions: There is a good correlation between the automated method and the manual methods for the assessment of peritoneal fluid samples in CAPD patients. However, in the assessment of fluids with less than 300 cell/mu L, the manual method should be preferred for critical clinical decisions.
Cytomegalovirus Pneumonia and Pulmonary Haemorrhage in a Patient With Polyarteritis Nodosa
(Pakistan Medical Assoc, 2016) Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Emre, Habib; Soyoral, Lokman; Goktas, Ugur
Cytomegaloviruses are opportunistic pathogens that cause lung infection in immunocompromised individuals. A 24-year-old male was admitted to the hospital with complaints of cough, fever and dyspnoea. He was receiving immunosuppressive therapy for polyarteritis nodosa. A chest X-ray showed heterogeneous right-sided opacity in the middle and lower lung zones. The diagnosis of cytomegalovirus pneumonia was confirmed by positive test for serum cytomegalovirus IgM antibodies. One day after admission, haemoptysis developed and patient with hemoptysis who had shortness of breath was intubated. Computed tomography (CT) showed bilateral alveolar opacity.
Dialysis Therapy for Lactic Acidosis Caused by Metformin Intoxication: Presentation of Two Cases
(Sage Publications Ltd, 2011) Soyoral, Yasemin Usul; Begenik, Huseyin; Emre, Habib; Aytemiz, Enver; Ozturk, Mustafa; Erkoc, Reha
Metformin is an oral antidiabetic, which is frequently used in the treatment of type II diabetes mellitus. Serious side effects may be seen during the administration of high doses of metformin. Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis.
Effectivity of One Session Charcoal Hemoperfusion Treatment in Severe Carbamazepine Poisoning
(Kowsar Publ, 2013) Isik, Yasemin; Soyoral, Lokman; Karadas, Sevdegul; Emre, Habib; Cegin, Muhammed Bilal; Goktas, Ugur
A carbamazepine intoxication with suicide attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. We report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. On admission, the patient was comatose and required ventilator support. Hemoperfusion with coated activated charcoal successfully decreased the serum carbamazepine concentration from 45 mu g mL(-1) to 21 mu g mL(-1) within 2 h, with subsequent clinical improvement.
Evaluation of Patients With Acute Renal Failure
(2014) Seven, İsmet; Emre, Habib
Bu araştırma ile bölgemizdeki akut böbrek yetmezliği tanısı ile yatırılan veya hastanede yatmakta iken akut böbrek yetmezliği gelişen hastaların demografik özellikleri, hastaneye yatış nedenleri, böbrek yetmezliği nedenleri ve böbrek yetmezliği gelişimi için risk faktörleri, hemodiyaliz ihtiyacı ve mortalite ile ilişkili faktörler incelenmesi amaçlandı. Çalışmaya Yüzüncü Yıl Üniversitesi Tıp Fakültesi hastanesinde yatarak tedavi gören 18-85 yaş arasında akut böbrek yetmezliği tanısıyla yatan veya hastanede yatmakta iken akut böbrek yetmezliği gelişen 72 hasta ve kontrol grubu olarak ise 50 sağlıklı birey alındı. Elde edilen verilerin istatistik değerlendirilmesi sürekli değişkenler için tanımlayıcı istatistikler; ortalama, standart sapma, minimum ve maksimum değer olarak ifade edilirken, kategorik değişkenler sayı ve yüzde olarak ifade edildi. Sürekli değişkenlerin gruplarını karşılaştırmada Student t testi yapıldı. Bu değişkenler arasındaki ilişkileri belirlemede Pearson korelasyon katsayısı hesaplandı. Kategorik değişkenler arasındaki ilişkileri belirlemede ise Ki-kare testi ve olabilirlik oran testi kullanıldı. p<0,05 değeri istatistiksel olarak anlamlı kabul edildi. Hastalar böbrek yetmezliği nedenlerinın dağılımı 28 (% 38,9) prerenal, 37 (% 51,4) renal, 7 (% 9,7) postrenal olarak bulundu. Böbrek yetmezliği nedenine göre hastaların yaş ortalaması postrenal grupta daha yüksek olmakla birlikte grublar arasında istatistiksel olarak anlamlı fark yoktu (p<0,05). Renal böbrek yetmezliği olan hastalarda başvuru anındaki tansiyon değerleri daha yüksekken, BUN, kreatinin ve ferritin değerleri postrenal böbrek yetmezliğinde, Hemoglobin ve hematokrit değerleri ise prerenal böbrek yetmezliği hastalarında daha yüksekti (p<0,05). Akut böbrek yetmezliği gelişimi ile ilişkili faktörler, ileri yaş, ilaç kullanımı, komorbit hastalık varlığı, daha önce hastaneye yatış öyküsü olması, ateş, WBC, nötrofil, glukoz, fosfor kortizol, PTH ve ferritin yüksekliği, Hb, Htc, kalsiyum ve albumin düşüklüğü olarak bulundu. Hastaların 11'inde (% 15,2) hemodiyaliz endikasyonu vardı. Hastaların diyaliz endikasyonları anüri, hipervolemi, üremik ensefolapati, üremik hıçkırık, üremik kanama açısından operasyon öncesi diyaliz, tömör lizis sendromu ve hiperürisemi oluşturdu. Diyalize alınan hastaların BUN, kreatinin, ALT, AST, fosfor ve TSH değerleri diyalize girmeyen hastalara göre daha yüksekti (p<0,05). Diyalize ihtiyacı ile mortalite oranı arasında istatistiksel olarak anlamlı ilişki tespit edilmedi. Hemodiyaliz ile ilişkili yüksek korelasyon gösteren faktörler; ABY nedeninin renal ABY'ye bağlı olması, başvuru BUN ve kreatinin değerinin yüksek olması olarak bulundu. Hastaların 15'i (%20,8) ex oldu. Hastaların ex nedenleri sepsis, serebro vasküler enfarktüs, malignite, kardiovasküler hastalık ve sistemik vaskülite bağlıydı. Ex olan hastaların BUN, AST, fosfor, kortizol, ferritin değerleri Ex olmayan hastalara göre daha yüksek, hemoglobin, platelet, kalsiyum, total protein, albümin FT4, değerleri ise daha düşüktü (p<0,05). Diyalize giren hastalar ile karşılaştırıldığında ise ex olan hastalarda hemoglobin, platelet, kreatinin daha düşük, kortizol değerleri daha yüksekti (p<0,05). Exitus olan hastalardaki albumin değeri taburcu olan hastalara göre düşük bulundu (p<0,05). Mortalite ile ilişkili yüksek korrelasyon gösteren faktörler; başvuru anındaki fosfor, kortizol ve ferritin yüksekliği olarak bulundu.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Chronic Renal Failure Due To Nephrotic Syndrome: a Rare Case Report
(Pergamon-elsevier Science Ltd, 2012) Erdur, Fatih Mehmet; Soyoral, Yasemin Usul; Emre, Habib; Begenik, Huseyin; Canbaz, Esra Turan; Erkoc, Reha
Objectives: Fenofibrate is a fibric acid derivative that is used alone or combination with statins in the treatment of hyperlipidemia. These drugs have potential risks, including rhabdomyolysis and acute renal failure. Despite reports of rhabdomyolysis with the use of fenofibrate alone or with statin-fibrate combinations, there have been no cases of rhabdomyolysis described when fenofibrate was used alone to treat patients with chronic renal failure owing to nephrotic syndrome. Design and methods: We report on a 26-year-old male who presented with fenofibrate-induced rhabdomyolysis with chronic renal failure due to nephrotic syndrome. Results: After the discontinuation of fenofibrate, the patient was treated with intravenous fluid replacement and urine alkalization. Subsequently, his clinical and biochemical findings improved. Conclusions: Before starting fenofibrate therapy, the causes of secondary hyperlipidemia, especially nephrotic syndrome, should be investigated. In the presence of chronic renal failure and hypoalbuminemia, the fenofibrate dose should be adjusted. Physicians should be aware of the potential toxicities of fenofibrate, and patients should be informed about its potential side effects. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Stage 4 Chronic Renal Failure Due To Diabetes Mellitus
(Pakistan Medical Assoc, 2012) Soyoral, Yasemin Usul; Canbaz, Esra Turan; Erdur, Mehmet Fatih; Emre, Habib; Begenik, Huseyin; Erkoc, Reha
Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaemia. Although several case reports of rhabdomyolysis have been reported due to the combination of statin and fenofibrate, fenofibrate alone rarely causes rhabdomyolysis. When administering fenofibrate in chronic renal failure, dose should be adjusted. Here, we report a case with fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure.
A Flare of Ulcerative Colitis Accompanied With Cerebral Sinus Venous Thrombosis and Bilateral Thalamic Infarctus: A Case Report
(Elmer Press inc, 2012) Dulger, Ahmet Cumhur; Begenik, Huseyin; Demirtas, Levent; Esen, Ramazan; Emre, Habib
Ulcerative colitis (UC) is a chronic inflammatory and recurrent disorder that is characterized by bowel inflammation. Some patients with Inflammatory Bowel Disease (IBD) have acute, severe, and sometimes devastating intracranial complications that require immediate medical intervention. Cerebral sinus vein thrombosis is a rare but serious extraintestinal complication associated with ulcerative colitis. Herein we report a 30-year-old man with UC who presented with a flare of gastrointestinal symptoms with mental obtundation and apathy. Total colonoscopy revealed active colitis and cranial MRI showed extensive cerebral sinus venous thrombosis with thalamic infarcts. Because the patient was clinically unstable metilprednisolon with low molecular weight heparin were administered. Two days after treatment the patient was died despite all medical efforts.
Hepatic Encephalopathy in Connection With Budd-Chiari Syndrome Due To Infection With Echinococcus Multilocularis: a Case Report
(Elmer Press inc, 2011) Dulger, Ahmet Cumhur; Kemik, Ozgur; Selvi, Fatih; Begenik, Huseyin; Emre, Habib; Erdur, Fatih Mehmet
Budd-Chiari syndrome (BCS) is a hepatic venous outflow block generally resulting from disorders affecting hepatic venous system. Elevated hepatic venous pressure results in portal hypertension. BCS may also cause hepatic encephalopathy. Echinococcus multilocularis is a tapeworm parasite and the natural course of the disease may affect liver parenchyma as well as hepatic venous tree. It is the most terrible parasitic disease of the liver and is easily confused with hepatic malignancies. Albendazole therapy may suppress disease progression. Alveolar echinococcosis of the liver rarely causes Budd-Chiari syndrome-related hepatic encephalopathy (HE). We report a rare case of alveolar echinococcosis-related BCS with HE, who was successfully managed by rifaximin and albendazole.
Hydrocephaly Secondary To Central Vein Thrombosis in a Hemodialysis Patient
(Professional Medical Publications, 2012) Emre, Habib; Soyoral, Yasemin Usul; Erdur, Fatih Mehmet; Begenik, Huseyin; Sayin, Refah
Neurological disorders can be observed in hemodialysis patients due to uremic encephalopathy, electrolyte imbalance, infection, medications, glucose intolerance, hypoxia and psychiatric disorders. We present a case of hydrocephalus consequent to central vein thrombosis that is rarely seen in an adult hemodialysis patient and which causes neuro-psychiatric symptoms.
Investigation of Erbb-2 Overexpression on Patients With Gastric Cancer in Eastern Anatolia of Turkey
(Aves, 2013) Emre, Habib; Tekin, Salim Basol; Dogan, Hasan; Cayir, Kerim; Bilici, Mehmet; Sipal, Sare; Pirim, Ibrahim
Background/aims: In the present study, the frequency of ErbB-2 overexpression and its relationship with pathologic parameters on patients with gastric cancer in Eastern Anatolia of Turkey was studied. Materials and Methods: A total of 32 newly diagnosed patients were enrolled in the study. DNA isolation was performed on paraffinized tumor tissues obtained from patients by endoscopy or surgical resection. ErbB-2 overexpression was investigated from the isolated DNA by "Real Time Polymerase Chain Reaction". Results: ErbB-2 positivity was detected in five (15.6%) of 32 gastric cancer patients. The correlation between distant metastases and ErbB-2 positivity was found to be statistically significant (p=0.04). Additionally, no statistically significant correlation was noted between ErbB-2 positivity and parameters such as level of differentiation (p=0.7), the depth of tumor invasion (p=0.08), lymph node metastases (p=0.6), Lauren's classification (p=0.4), World Health Organization classification (p=0.3), tumor, node, metastasis staging (p=0.3) and tumor localization (p=0.2). Lymph node involvement was present in all ErbB-2 positive patients, the depth of tumor invasion was T3 (one case) and T4 (four cases) with the cardia being the most common location, which was remarkable, though not statistically significant (p>0.05). All ErbB-2 positive patients were detected with intestinal-type gastric cancer according to Lauren's classification and with the tubular-type according to World Health Organization classification. Conclusion: According to our findings, given the rates ofErbB-2 overexpression (15.6%) in gastric cancer, the investigation ofErbB-2 overexpression as an important biomarker in humanized monoclonal-antibody treatment in patients with gastric cancer was considered appropriate.
Non-Secretory Multiple Myeloma in a Hemodialysis Patient With Hypercalcemia
(Galenos Yayincilik, 2012) Erdur, Fatih Mehmet; Soyoral, Yasemin Usul; Emre, Habib; Begenik, Huseyin; Tasdemir, Mehmet; Erkoc, Reha
Penetration of Arcus Aorta by Tunneled Cuffed Catheter: Should Fluoroscopic Guidance Be Preferred
(Wichtig Publishing, 2014) Yavuz, Alpaslan; Yuksel, Enver; Gur, Ali Kemal; Bora, Aydin; Bulut, Mehmet Deniz; Emre, Habib
Seasonal Variability of Parathyroid Hormone and Its Related Biochemical Parameters in Hemodialysis Patients
(Drunpp-sarajevo, 2012) Soyoral, Yasemin Usul; Emre, Habib; Demirkiran, Davut; Begenik, Huseyin; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objective: We aimed to investigate the seasonal variability of the parathyroid hormone levels and its related biochemical parameters in hem dialysis patients. Methods: We retrospectively analyzed the data of 81 hemodialysis patients (36 female, 45 male; the mean age: 54, 8 +/- 19, 3) between 2008 and 2009 years. We compared the seasonal variability of the mean levels of parathyroid hormone (PTH), calcium (Ca), phosphor (P), and alkaline phosphatase (ALP). Results: The lowest level of PTH (163 pg/ml (26-1894 pg/ml) was detected during the summer, followed by the fall, and then by the winter (273 pg/ml (23.7-2500 pg/ml); 275 pg/ml (17.9-2122 pg/ml) respectively). The highest level of PTH (292 pg/ml (9, 8-2289 pg/ml) was detected during the spring. Similar to PTH, the peak level of ALP was detected during the summer. The lowest level of Ca was detected during the spring. The level of P did not demonstrate any seasonal variability. Conclusions: We observed that the level of PTH was showed seasonal variability. The seasonal variability of PTH and its related biochemical parameters should be considered in medical treatment of secondary hyperparathyroidism in hemodialysis patients.
Serum Leptin Levels in Gastric Cancer Patients and the Relationship With Insulin Resistance
(Termedia Publishing House Ltd, 2015) Begenik, Huseyin; Aslan, Mehmet; Dulger, Ahmet Cumhur; Emre, Habib; Kemik, Ahu; Kemik, Ozgur; Esen, Ramazan
Introduction: Serum leptin levels have been examined in various cancers, with conflicting results. However, there is limited information regarding serum leptin levels and insulin resistance in gastric cancer patients. Therefore, we aimed to investigate serum leptin levels, performance status, insulin levels and insulin resistance in patients with gastric cancer. In addition, we examined the relationship between these measurements and leptin levels. Material and methods: Thirty-nine patients with gastric cancer and 30 control subjects were enrolled in the study. Serum leptin, total protein, albumin, growth hormone, insulin and glucose levels were measured. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Results: Serum levels of insulin, glucose and growth hormone and insulin resistance were significantly lower in gastric cancer patients than controls (p < 0.05 for all). In the Pearson correlation analysis, insulin resistance was found to be significantly correlated with serum leptin levels in gastric cancer patients (r = 0.320, p = 0.047). We observed a significant negative correlation between performance status and insulin resistance in patients with cachexia (r = -0.512, p = 0.030), while no association was found in non-cachectic patients. Conclusions: We concluded that serum leptin levels are significantly lower in gastric cancer patients. In addition, gastric cancer patients have decreases in insulin levels, insulin resistance and growth hormone levels. This study found a positive association between serum leptin levels and insulin resistance. Moreover, there is a negative association between serum leptin levels and growth hormone levels. Thus, low insulin and growth hormone levels may suppress the production of leptin in gastric cancer patients.
Serum Malondialdehyde Levels, Myeloperoxidase and Catalase Activities in Patients With Nephrotic Syndrome
(Taylor & Francis Ltd, 2013) Begenik, Huseyin; Soyoral, Yasemin Usul; Erkoc, Reha; Emre, Habib; Taskin, Abdullah; Tasdemir, Mehmet; Aslan, Mehmet
Objectives: Some studies have indicated the pathophysiological importance of reactive oxygen species (ROS) in patients with nephrotic syndrome. Myeloperoxidase (MPO) is a leukocyte-derived enzyme-generating ROS that has been proposed to exert a wide array of pro-atherogenic effects throughout all stages of the atherosclerotic process. The aim of this study was to investigate the serum malondialdehyde (MDA) levels, MPO and catalase activities in patients with adult nephrotic syndrome. Patients and Methods: Twenty-four patients with nephrotic syndrome and 24 healthy controls were enrolled. Serum MPO activity, catalase activity, and MDA levels were assessed. Results: Serum MPO activity and MDA levels were significantly higher in patients with nephrotic syndrome than controls (both, P < 0.001), while catalase activity was significantly lower (P < 0.001). Serum catalase activity was found to be significantly correlated with MPO activity (r = -0.417, P = 0.003) and MDA levels (r = -0.532, P = 0.007). The serum MDA levels were also found to be significantly correlated with MPO activity (r = 0.419, P = 0.003). Conclusions: We concluded that serum MPO activity and oxidative stress were increased and that serum catalase activity was decreased in patients with adult nephrotic syndrome. In addition, these results indicate that increased MPO activity is associated with an oxidant-antioxidant imbalance that may contribute to atherosclerosis in patients with adult nephrotic syndrome.