Browsing by Author "Kilic, Kubra"

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Intermolecular Heterocyclization of Alkynones With 2-Mercaptoacetaldehyde Under Metal-Free Conditions: Synthesis of 2,3-Disubstituted Thiophenes
(Pergamon-elsevier Science Ltd, 2015) Vatansever, Erol Can; Kilic, Kubra; Ozer, Merve Sinem; Koza, Gani; Menges, Nurettin; Balci, Metin
A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.
A Retrospective Analysis of Prognostic Factors and Treatment Results of Gastric Adenocarcinomas Treated With Postoperative Chemoradiotherapy
(Kare Publ, 2014) Izmirli, Mustafa; Kilic, Kubra; Yilmazer, Gokhan; Nart, Maruf
OBJECTIVES This retrospective study aimed to evaluate effects of various factors on survival in patients living in the basin of Lake Van who were diagnosed with gastric cancer, and given postoperative chemoradiotherapy (CRT). METHODS One hundred and four patients with gastric adenocarcinoma w ho received adjuvant CRT were evaluated retrospectively. RESULTS The median overall survival time was 28.30 months, and 3-year and 5-year median survival rates were 47.6% and 33.6%, respectively. The median disease-free survival, however, was 23.97 months, and 3-year and 5-year disease-free survival rates were 38.1% and 26.2%, respectively. Regarding with the evaluation of various prognostic factors, the number of involved lymph nodes (LN) and positive surgical margins for overall survival; the performance status for disease-free survival; and the rate of LN involvement along with the number of chemotherapy treatments >= 3 for both disease-free survival and overall survival were determined statistically significant via univariate analysis. In multivariate analysis, positive surgical margins, the number of involved LNs and the rate of LN involvement were defined statistically significant for overall survival, whereas no parameter was determined statistically significant for disease-free survival. CONCLUSION An improvement in overall survival and disease-free survival has been achieved with the treatment of adjuvant CRT in patients with gastric cancers.