Intermolecular Heterocyclization of Alkynones With 2-Mercaptoacetaldehyde Under Metal-Free Conditions: Synthesis of 2,3-Disubstituted Thiophenes

Abstract

A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.