Browsing by Author "Kozat, S."

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Clinicopathological and Biochemical Evaluation of Feline Infectious Peritonitis in Turkish Van Cats
(Hellenic veterinary Medical Soc, 2022) Ozbek, M.; Ozkan, C.; Kaya, A.; Yildirim, S.; Kozat, S.; Akgul, Y.
This study was performed to evaluate serum homocysteine and nitric oxide levels in cats with Feline Infectious Peritonitis and present biochemical and clinicopathological alterations related to the disease. The material of this study consisted of 30 Turkish Van Cats of different ages and genders with Feline Infectious Peritonitis that were definitely diagnosed by post-mortem examinations and immunohistochemistry. The control group consisted of 6 healthy Turkish Van Cats of different ages and genders that were brought for routine clinical examination. Cats in the study group had clinical findings such as loss of appetite, weight loss, high fever, persistent fever, jaundice, dehy-dration, vomiting, respiratory system symptoms, anemia, nervous findings, uveitis, and ascites. These cats were mon-itored and following the death, post-mortem examinations were performed and cases with a definitive diagnosis were included in the study. Among the cats consisting study group, while 25 had the dry form of the disease, 5 had wet form. According to the hematological results, there was a statistically significant reduction in platelet counts. The biochemi-cal results showed statistically significant alterations that creatinine, aspartate aminotransferase, alkaline phosphatase, creatine kinase myocardial band, homocysteine, and nitric oxide concentrations were higher than the control group. Besides albumin concentrations were lower and the albumin/globulin ratio was 0.53. As a result; this is the first detailed study in Turkish Van Cats with Feline Infectious Peritonitis that evaluated clinical, hematological, biochemical, and pathological findings. Furthermore, serum homocysteine and nitric oxide levels were evaluated for the first time in cats with vasculitis which is the most important complication of the disease. It is concluded that the evaluation of serum homocysteine and nitric oxide concentrations in Feline Infectious Peritonitis may assist the antemortem diagnosis of e disease.
Evaluation of Cobalt, Copper, Manganese, Magnesium and Phosphorus Levels in Cows With Clinical Ketosis
(Univ Agriculture, Fac veterinary Science, 2016) Kaya, A.; Ozkan, C.; Kozat, S.; Akgul, Y.; Ozbek, M.
The objective of this study was to examine the association between 13-hydroxybutyrate (BHBA) and glucose, cobalt (Co), copper (Cu), manganese (Mn), magnesium (Mg), and phosphorus (P) in cows with clinical ketosis and control group. At the beginning; while serum glucose levels, Co, Cu, Mn, Mg and P concentrations in cows with clinical ketosis were lower, BHBA levels were higher than control group. At the 3rd day after the treatment, serum Co, Cu, Mn and P concentrations were lower in cows with clinical ketosis than control group. According to these results, mineral level decrease was detected in cows with ketosis. It is thought that there should be more study performed about the contribution of minerals to the treatment of ketosis. This study will provide an insight to the studies will be performed in this respect. (C) 2015 PVJ. All rights reserved
Evaluation of Cobalt, Vitamin B12 and Homocystein Levels in Cattle Infected With Theileria Annulata
(Journal Livestock Science, 2017) Denizhan, V.; Kozat, S.; Ozkan, C.
This study was conducted to assess the pattern of changes and the relative values of homocysteine in bovine tropical theileriosis. The diseased group comprised of 20 cattle (2-3 years old) naturally infected with Theileria annulata. As control group, 10 uninfected cattle were also sampled. Whilecobalt (Co), vitamin B-12, folate, total protein (TP), globulin values were determined significantly lower than control group (P<0.001), serum homocystein (Hcy), creatine kinasemyocardial band (CK-MB), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), creatinine, urea, and blood urea nitrogen (BUN) concentrations were determined higher than control group (P<0.001). As a result, decreases in serum B-12 vitamin concentrations of cattle with theileriosis lead to increases in serum Hcy level.
Evaluation of Retinol, Cholecalciferol, Α-Tocopherol and Phylloquinone Levels in Naturally Infected Calves With Eimeriosis
(Hellenic veterinary Medical Soc, 2025) Denizhan, V; Kozat, S.; Ekin, S.
The aim of this study was to evaluate whether serum vitamin A (retinol), vitamin D (cholecalciferol), vitamin E (alpha-tocopherol), and vitamin K (phylloquinone) levels changed in naturally infected calves with eimeriosis. The study was conducted on a total of 70 calves, 55 with eimeriosis and 15 healthy (control) calves of different races, sexes, and ages ranging from 26 to 60 days, with complaints of bloody diarrhea, weight loss and tenesmus. As result of statistical analysis; serum vitamin A, D, E, and K concentrations of calves with eimeriosis were significantly lower than the control group (P<0.001). As a result; significant decreases were detected in serum retinol (vitamin A), cholecalciferol (vitamin D), alpha-tocopherol (vitamin E), and phylloquinone (vitamin K) levels concentrations of calves with eimeriosis. It was concluded that the application of preparations containing vitamins A, D, E and K, in addition the routine treatment protocol applied in cases of eimeriosis or other diarrhea, may be beneficial in the treatment and prognosis of eimeriosis.
Evaluation of Serum Cobalt, Copper, Iron, Calcium, Phosphorus and Magnesium Concentrations in Cattle Naturally Infected With Theileria Annulata
(Ataturk Universitesi, 2017) Denizhan, V.; Kozat, S.; Özkan, C.; Tuncer, S.S.
The purpose of this study was to evaluate serum albumin, glucose, calcium (Ca), cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), and phosphorus (P) in cows with naturally infected with Theileria annulata. The material of this study was a total of 15 cattle with different ages, breeds and genders diagnosed as theileriosis according to clinical and microscopical examination. According to statistical analyses of biochemical parameters; serum glucose, Ca, Co, Cu, Fe, Mg, and P concentrations were detected significantly low in cattle with theileriosis (P<0.001). In conclusion; mineral substance levels were altered in cattle naturally infected with Theileria annulata. Additionally to the classical treatment of theileriosis, administering mineral supplements including Ca, Co, Fe, Cu, Mg, and P to the animals is thought to be more useful in treatment.
Evaluation of Serum Homocysteine and Nitric Oxide Concentrations Compared With Other Biochemical Parameters in Sheep Naturally Infected With Fasciola Hepatica
(Hellenic Veterinary Medical Society, 2020) Denizhan, V.; Kozat, S.
This study aims to determine the changes in serum homocysteine (Hcy) and nitric oxide (NO) concentrations in sheep naturally infected with F. hepatica. The animal material of the study consisted of a total of 50 sheep: 40 sheep with fascioliasis and 10 healthy sheep. The statistical analysis indicated that serum homocysteine concentrations, folate and vitamin B12 levels of the sheep infected with F. hepatica were higher than those of the control group (P<0.001 P<0.001 and P<0.05, respectively), whereas the nitric oxide levels of the sheep infected with F. hepatica were significantly lower than those of healthy sheep (P<0.001). In conclusion, it is thought that vitamin B12 and folate are not used sufficiently for the conversion of homocysteine to methionine in the remethylation cycle due to the damage in the liver tissue of sheep naturally infected with F. hepatica. This results in the increase of homocysteine which in turn inhibits the formation of nitric oxide. © 2020 V. DENIZHAN, S. KOZAT.
Evaluation of Total Antioxidant, Total Calcium, Selenium, Insulin, Free Triiodothyronine and Free Thyroxine Levels in Cows With Ketosis
(Islamic Azad Univ, Rasht, 2017) Kozat, S.; Yuksek, N.
Ketosis is an important metabolic disease of high milk-producing cows. There are significant changes in many metabolite and hormonal concentrations in metabolic diseases. This study was carried out to assess the concentrations calcium (Ca), selenium (Se), total antioxidant (TAOC), insulin, free triiodothyronine (fT(3)) and free thyroxine (fT(4)) in cows with subclinical and clinical ketosis. This study included 20 dairy cows within the first two months of lactation, aged between 4-8 years. Cows with beta-hydroxybutyrate acid (BHBA) concentrations 1.20 mmol/L were considered healthy, whereas 1.20 and 1.50 mmol/L were considered subclinical and 1.60-2.20 mmol/L were classified as clinically ketotic. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), low density lipoprotein (LDH), glucose, Ca, plasma TAOC capacity and BHBA concentrations were performed spectrophotometrically. Serum insulin, free triiodothyronine and free thyroxine concentrations were measured using the chemi-luminescence method. Serum Se concentrations were measured using an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). In conclusion, significant changes were noted in decreased concentrations of TAOC, Ca, Se, fT(3), fT(4) and insulin in cows with subclinical and clinical ketosis. The study identified important parameters, changes in the levels of these parameters will be important in determining the treatment and prognosis of the disease. Their use may also help reduce the economic losses suffered by dairy farmers as a result of the disease.
Importance of Colloidal Solutions in Fluid Treatment
(Ataturk Universitesi, 2017) Kozat, S.
This issue was aimed to display importance of colloidal solutions for fluid treatment. Occurring dehydration or hypovolemia shock states due to diseases, which was not applied effective therapy fluid, this situation will be followed by shock, irreversible cell damage, organ failure and finally, death. However, isotonic crystalloid solutions such as 0.9% NaCl and Lactated Ringer, which are commonly used in practice, are required to be given in large volumes due to circulation of 1 / 4-1 / 5, and this leads to significant complications such as pulmonary edema. On the other hand, colloidal solutions used for the treatment of shocks with hypovolemia increase the volume of blood rapidly by pulling fluid to the intravascular region from the extravasculer and intracellular compartment and its effectiveness is reported to last 12-24 hours. But colloidal solutions, which are disadvantages such as, pulmonary edema, excessive sensibility reactions decreased calcium concentrations are also excessive expensive. In conclusion, administration of colloidal solution for fluid treatment induced greater and more persistent increase in plasma volume than of those of crystalloid. However, in order to minimize the disadvantages of colloidal solutions, it is recommended that colloidal solutions be mixed with crystalloid solutions at certain ratios in fluid treatment.
The Importance of Colostrum Management in Newborn Calves
(Ataturk Universitesi, 2019) Kozat, S.
Colostrum is a special and important type of milk that should be ingested by newborn calves in order to produce immunity against diseases in the first 28 days of life. Giving colostrum to calves is the most important factor for calf survival and maintaining health. In many countries, one of the most important reason for calf deaths is inadequate intake of colostrum. A newborn calf should ingest approximately 5% body weight of colostrum in the first 6 hours as first meal and in the first day, this amount should be 10% of body weight in the first 3-4 meals. Passive transfer failure occurs when the neonatal calves do not ingest adequate and suitable colostrum as stated time and amounts. Besides, passive transfer failure also leads to low intake of antibodies in the calves. This condition leads to increase in death rates, and losses associated with calf health, welfare and productivity. Therefore, a successful colostrum management programme is necessary for decreasing neonatal calf deaths and increasing immunity against diseases. The purpose of this study is to give detailed information related with maintaining and monitoring an effective colostrum programme, as well as discussing the relations between neonatal diseases and important components of colostrum. © 2019 Ataturk Universitesi. All rights reserved.
Investigation of Serum Amyloid A, Haptoglobin and Fibrinogen Levels in Sheep Infected With Fasciola Hepatica
(Journal Livestock Science, 2019) Denizhan, V.; Kozat, S.; Yilmaz, A. B.
The present study aimed to determine the changes in serum haptoglobin, serum amyloid A and fibrinogen levels in pathological disorders of sheep liver with Fasciola hepatica. Sixty sheep (50 with fascioliasis and 10 healthy) were used in the present study. Statistical analysis results demonstrated that SAA, Hp and fibrinogen concentration levels of the sheep infected with Fasciola hepatica were higher when compared to SAA, Hp and fibrinogen concentration levels in healthy sheep (P <0.05). While ALT, AST and GGT values of sheep infected with Fasciola hepatica were found to be higher than those of the healthy sheep, serum TP, ALB and glucose levels were lower. In statistical analysis, it was found that WBC, Neu and Eo values of sheep infected with Fasciola hepatica were higher when compared to WBC, Neu and Eo values in the control group. In conclusion, serum haptoglobin, serum amyloid A, and fibrinogen levels were significantly higher in sheep infected with Fasciola hepatica when compared to the healthy group. Due to the fact that increases in serum haptoglobin, serum amyloid A and fibrinogen levels in sheep with fasciolosis were similar to those observed in liver disorders, it was suggested that these parameters could be useful in determination of the liver damage levels and prognosis and in studies on liver disorders.
Serum Adenoslne Deaminase Activity and Biochemical Parameters in Chronic Fascioliasis in Sheep
(2006) Kozat, S.; Ekin, S.; Kaya, A.; Denizhan, V.
Serum Homocysteine Levels in Calves With Foot and Mouth Disease
(Medwell Journals, 2013) Kaya, A.; Kozat, S.; Ozkan, C.; Yildirim, S.; Akgul, Y.; Akgul, O.
The association between serum Homocysteine (Hey) and myocarditis in calves with Foot and Mouth Disease (FMD) are not well defined. To investigate the relationship between serum Hey concentrations and myocarditis in healthy calves and calves with FMD. A total of 9 healthy calves (control) and 15 calves with FMD. In the study, all animals underwent a comprehensive clinical and laboratuar findings study to document cardiac health or presence of FMD. Blood samples were collected via jugular venipuncture. Serum Hey, Nitric Oxide (NO), cardiac Troponin I (cTnl) concentrations, serum levels of activity Creatine Kinase (CK), Lactac Dehydrogenase (LDH) and cardiac origin Creatine Kinase (CK-MB) were measured. Serum Hey, NO, cTnl, CK, CK-MB and LDH values in calves with FMD significantly higher compared to control (p<0.01, p<0.001, p<0.01, p<0.001, p<0.001 andp<0.05, respectively). The results suggest that determination of serum Hey concentrations in calves with clinical signs compatible with FMD might prove useful as a guide to quantify cardiac remodeling associated with heart damage. © Medwell Journals, 2013.