Browsing by Author "Tuğrul, T."

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Dosimetric Comparison of 3d-Conformal and Imrt Radiotherapy Techniques in Gastric Cancer
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Çakır, T.; Yılmazer, G.; Tuğrul, T.
Stomach cancer is a malignancy which has poor prognosis and takes place on the top among deaths related with cancer in the world. Anatomically, stomach has relations with critical organs as heart, liver, kidneys, intestine and spinal cord. Doses which are taken by surrounding critical organs in planning adjuvant radiotherapy of stomach cancer have importance in terms of the control and toxicity. In this study, it was aimed to examine the best dose to target volume and the most appropriate treatment planning technique for maximum protection of organs at risk. The Intensity Modulated Radiation Therapy (IMRT) technique and the 3D-Conformal radiotherapy technique at patients who were operated for stomach cancer were compared in terms of dosimetry. This study was done on the Computed Tomography (CT) simulation images of 21 patients who applied to Van Yüzüncü Yıl University, Radiation Oncology Department. CT simulation of patients was taken with 3 mm thickness at 60th second using intravenous contrast agent. Then CT images were transferred to Prowess Panther treatment planning system. In IMRT planning, 5 fields planning were done with 6 MV photon energy. 3D-conformal planning was performed in 4 fields using 6 and 15 MV photon energy. It is seen that IMRT technique is statistically more advantageous against conformal radiotherapy technique in terms of right-left kidney V20, bilateral kidney V20 and mean dose of liver at the radiotherapy technique applied to the patients who had operation for stomach cancer. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Examination of Dosimetric Verification of Prowess Panther Treatment Planning System Using Monte Carlo Method for Small Fields
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Tuğrul, T.
Treatment planning systems (TPS) have an important role in the implementation of radiotherapy treatment. Quality control of TPS is extremely important in terms of treatment reliability. In this study, it was aimed to make quality control of TPS by comparing the data obtained from the PROWESS Panther TPS with the results of the Monte Carlo simulation for small fields. In this study, TPS used in the radiation oncology department was examined. For MC simulation, BEAMnrc and DOSXYZnrc codes were used in modeling and dose measurement of linear accelerator device. Gamma analysis method was used to compare measurement results. When we examine the gamma analysis for PDDs in the study, the gamma values obtained in the 3x3 cm2, 4x4 cm2 and 5x5 cm2 field sizes for the 3% and 3mm criterion provide this criterion for each measurement point. The fact that each dose point in the measurement field is less than 0.1 gamma value indicates that the dose profiles obtained in PROWESS Panther TPS are in good agreement with the MC results. The doses calculated by PROWESS Panther TPS were found within the reference limits. It can be concluded that the dose calculated by PROWESS Panther TPS in homogeneous environments is within acceptable limits for use in radiotherapy. Studies should also be carried out in non-homogeneous environments such as lung, bone and soft tissue in order to obtain more accurate results about PROWESS Panther TPS. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of Shielding Parameters of Fast Neutrons for Some Chemotherapy Drugs by Different Calculation Methods
(Prof.Dr. İskender AKKURT, 2023) Şahmaran, T.; Tuğrul, T.
In this study, we investigated the neutron attenuation properties of twelve different chemotherapy drugs utilizing various computational techniques. The computed fast neutron effective removal cross-section (ΣR, cm-1) results were compared with empirical formulas, Monte Carlo simulation data obtained from MCNP, MRCsC, and Phy-X/PSD computer program results. Additionally, within each calculation method, the half-value layer (HVL) and the mean free path (λ) values were determined. Our calculations revealed that, when compared to water and paraffin, Gemcitabine, Etoposide, Vincristine, and Doxorubicin exhibited the highest ΣR values, while Oxaliplatin exhibited the lowest ΣR value. Understanding and determining the radiation properties of drugs, especially in treatment methods involving radiation, will provide an advantage for both patients and clinical personnel. t © IJCESEN.