Browsing by Author "Vatansever, Erol Can"

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    Intermolecular Heterocyclization of Alkynones With 2-Mercaptoacetaldehyde Under Metal-Free Conditions: Synthesis of 2,3-Disubstituted Thiophenes
    (Pergamon-elsevier Science Ltd, 2015) Vatansever, Erol Can; Kilic, Kubra; Ozer, Merve Sinem; Koza, Gani; Menges, Nurettin; Balci, Metin
    A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.