PubMed İndeksli Yayınlar Koleksiyonu

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Amputations in Eastern Turkey (Van): a Multicenter Epidemiological Study
(Turkish Assoc Orthopaedics Traumatology, 2008) Dogan, Ali; Sungur, Ibrahim; Bilgic, Serkan; Uslu, Mustafa; Atik, Bekir; Tan, Onder; Akpinar, Fuat
Objectives: The indications for amputations vary among countries and different regions depending on many factors. This study was designed to evaluate amputations performed in the province of Van and to determine specific causes of amputations associated with geographical and. cultural characteristics of the region. Methods: A total of 475 amputations were performed in 440 patients (345 males, 95 females; mean age 28.5 years; range 3 months to 85 years) in medical institutions of Van between 1995 and 2005. The patients were evaluated with respect to age and sex, etiology, side and level of amputations, and surgical interventions performed. Results: Amputations were the most common in the 21 to 30-year age group with 109 patients. Pediatric patients below the age of 10 years accounted for 13.4%. Of all the amputations, 218 (45.9%) involved the upper extremity, and 257 (54.1%) involved the lower extremity. Amputations were right-sided in 223, left-sided in 188 patients, and 29 patients underwent multiple amputations. Trauma was the most common cause of amputations (n=177, 40.2%), with leading etiologies as gunshot injuries (n=45), land mine (n=3.3) and hand grenade (n=7) blasts. Other frequent indications apart from traumatic causes were diabetes mellitus (n=86), congenital diseases (n=33), and peripheral vascular disease (n=30). Causes more specific to regional characteristics were tandoor burns (n=7), mistreatment by traditional bonesetters (n=3), and frostbites (n=3). Replantation was performed in 24 patients, of which 15 (62.5%) were successful. Conclusion: Our region features gunshot injuries and land mine blasts as the most common traumatic causes of amputations.
The Assessment of Obsessive-Compulsive Symptoms
(Turkiye Sinir ve Ruh Sagligi dernegi, 2005) Besiroglu, L; Agargün, MY; Boysan, M; Eryonucu, B; Gülec, M; Selvi, Y
Objective: We examined the reliability and validity of the 60-and 41-item versions of the Padua Inventory (PI and PI-R) which were developed to assess the frequency and severity of obsessive-compulsive symptoms, in a Turkish population. Method: The sample consisted of 43 OCD patients, 30 non-OCD patients with other anxiety disorders, 30 nonobsessional depressed patients, 76 healthy adults, and 181 undergraduate students. We investigated internal consistency, test-retest reliability, and factor structure, concurrent and discriminant validity. Results: Psychometric analyses showed that both the original PI and PI-R had a high internal consistency and test-retest reliability. While principal factor analysis of the 41 items revealed six factors that are consistent with the PI-R, the factor structure of the original scale was not confirmed. All the subcales and total scores for both instruments were significantly correlated with the Yale-Brown scores except for the impulses subscale. There were significant differences between OCD patients and nonclinical samples in all total and subscale scores for both instruments. OCD patients scored significantly higher on the total, contamination/washing and checking subscales for both instruments than nonobsessional anxious, and depressed patients. While OCD patients scored significantly higher on the PI-R rumination scale than nonobsessional anxious patients, their PI impaired control subscale score was not different from that of the other clinical groups. Conclusions: The Turkish version of the PI has appropriate reliability and validity for assessing the frequency and severity of obsessive-compulsive symptoms.
Baseline Characteristics of a Patient Cohort and Predictors of In-Hospital Mortality in Coronary Care Units (morcor-Turk) Trial in Türkiye
(Kare Publ, 2024) Yilmaz, Ahmet Seyda; Kahraman, Fatih; Ersoy, Ibrahim; Taylan, Gokay; Kaya, Emin Erdem; Aydin, Ertan; Akkaya, Fatih
Objective: The MORtality in CORonary Care Units in T & uuml;rkiye (MORCOR-TURK) trial is a national registry evaluating predictors and rates of in -hospital mortality in coronary care unit (CCU) patients in T & uuml;rkiye. This report describes the baseline demographic characteristics of patients recruited for the MORCOR-TURK trial. Methods: The study is a multicenter, cross-sectional, prospective national registry that included 50 centers capable of 24 -hour CCU service, selected from all seven geographic regions of T & uuml;rkiye. All consecutive patients admitted to CCUs with cardiovascular emergencies between September 1-30, 2022, were prospectively enrolled. Baseline demographic characteristics, admission diagnoses, laboratory data, and cardiovascular risk factors were recorded. Results: A total of 3,157 patients with a mean age of 65 years (range: 56-73) and 2,087 (66.1%) males were included in the analysis. Patients with arterial hypertension [1,864 patients (59%)], diabetes mellitus (DM) [1,184 (37.5%)], hyperlipidemia [1,120 (35.5%)], and smoking [1,093 (34.6%)] were noted. Non -ST elevation myocardial infarction (NSTEMI) was the leading cause of admission [1,187 patients (37.6%)], followed by ST elevation myocardial infarction (STEMI) in 742 patients (23.5%). Other frequent diagnoses included decompensated heart failure (HF) [339 patients (10.7%)] and arrhythmia [272 patients (8.6%)], respectively. Atrial fibrillation (AF) was the most common pathological rhythm [442 patients (14%)], and chest pain was the most common primary complaint [2,173 patients (68.8%)]. Conclusion: The most common admission diagnosis was acute coronary syndrome (ACS), particularly NSTEMI. Hypertension and DM were found to be the two leading risk factors, and AF was the most commonly seen pathological rhythm in all hospitalized patients. These findings may be useful in understanding the characteristics of patients admitted to CCUs and thus in taking precautions to decrease CCU admissions.
A Case of Adem Mimicking Cerebral Adrenoleukodystrophy Based on Supratentorial Mri Findings
(Aves, 2014) Beyazal, Mehmet; Unal, Ozkan; Yilmaz, Sanem; Bora, Aydin
A 9-year-old male admitted for syncope also had the complains of pain and numbness in his legs and frequent falling down. There was a history of upper respiratory tract infection 10 days before. On neurologic examination, paraparesia and fall a sleep were identified. On magnetic resonance imaging, the symetric signal increases were seen in biparieto-occipital white matter intented to corpus callosum at T2-weighted sequences and cytotoxic edema was seen at diffusion-weighted images. Heterogeneous contrast enhancement was seen on these areas. In addition, at the C7-Th5 vertebrae levels, spinal cord had diffuse increased signal intensity and contrast enhancement. Acute disseminated encephalomyelitis was thought based on clinical and radiological findings. Steroid therapy was started. Significant improvement was shown after treatment. On 2-year follow-up, there was no recurrence. In conclusion, it must be kept in mind that acute disseminated encephalomyelitis can rarely present with biparieto-occipital involvement which extends to corpus callosum and can mimic adrenoleukodystrophy. For the differential diagnosis butterfly glioma, tumefactive demyelinating lesions or multiple sclerosis should be considered.
A Case of Idiopathic Ventricular Tachycardia Developed in a 14-Year Obese Patient Who Used Golden Berry Fruit Extract Pills for Weight Loss
(Turkish Soc Cardiology, 2013) Simsek, Hakki; Dogan, Adnan; Sahin, Musa; Gumrukcuoglu, Hasan Ali
Several studies have determined an association between obesity and increased risk of cardiac arrhythmia. Currently, due to the increased frequency of obesity, food-, plant-, and drug-based therapies for weight loss have gained great attention. A 14-year-old female patient presented with complaints of palpitation of one-hour onset. Blood pressure was 110/ 70 mmHg and peripheral pulses were present. She had been using golden berry extract pills three times a day for 10 days. Electrocardiograms showed nonsustained monomorphic ventricular tachycardia (VT). Echocardiographic examination and cardiac magnetic resonance imaging (MRI) were normal. She returned to sinus rhythm following amiodarone infusion. She refused electrophysiologic study, which plays a vital role in the diagnosis and establishment of the appropriate therapy. Although there was no decrease in body mass index (BMI) of the patient during the two-year follow-up, and she had no complaint or evidence of VT on intermittent rhythm, we have thought that VT might be stem from golden berry extract use, rather than obesity.
Case Report: Hookworm Infection in a Patient With Severe Anemia
(2009) Yilmaz, H.; Taş Cengiz, Z.; Ciçek, M.; Dülger, A.C.
In this study, a patient who was hospitalized with a severe anemia in the Internal Medicine Clinic of the Health Research and Application Hospital of Yüzüncü Yil University for one week is presented. The patient had fatigue, paleness and dizziness for one month and approximately 12 kg weight lost for four mounts previous to admission.. Severe iron deficiency anemia was diagnosed in the patient by laboratory analyses. Because there were no hematologic factors associated with severe anemia, the stool examination was also performed. In the Parasitology Laboratory, stool microscopy of the patient revealed numerous ova of hookworm. General condition of the patient well improved with anti-parasitic and anti-anemia treatment. It was concluded that patients with iron deficiency anemia diagnosed in health centers should be also examined for the intestinal parasitic diseases encountered rarely, and physicians should consider non-endemic parasitic diseases in their provinces.
Case Report: Treatment With Arterial Embolization in a Destroyed Cervical Pregnancy
(2003) Harman, M.; Zeteroglu, S.; Etlik, O.; Arslan, I.
Cervical pregnancy is a rare form of ectopic pregnancy. It is frequently associated with extensive hemorrhage, which, in severe cases, may be stopped only by hysterectomy. We report a case of a destroyed cervical pregnancy simulating cervical cancer. The patient was conservatively managed with simple selective uterine artery embolization without methotrexate administration. Her vaginal bleeding ceased after embolization. No additional treatment was given. The patient resumed normal menstruation two months after embolization.
Case Report: Two Plasmodium Vivax Malaria Cases in the Van Province
(2009) Karahocagil, M.K.; Baran, A.I.; Yaman, G.; Ciçek, M.; Bilici, A.; Binici, I.; Akdeniz, H.
Malaria is an important parasitic infection which is endemic in the Eastern Mediterranean and Southeastern Anatolia regions and sporadic in other regions of Turkey, while Plasmodium vivax is the most common cause. Two patients who were admitted to our hospital in October with complaints of high fever, chills, nausea-vomiting, generalized body pain and fatigue and diagnosed as P. Vivax malaria are presented, because they were two brothers with no history of travel outside of Van city.
Chest Trauma: Analysis of 126 Cases
(2000) Yalçinkaya, I.; Sayir, F.; Kurnaz, M.; Cobanoglu, U.
To evaluate our experience in chest trauma we review the records of the patients admitted for chest trauma to our service between December 1994 and April 2000. There were 126 patients (113 males, 89.7%), with an age range of 7 to 96 years (mean 35.3). The most frequent cause of chest injury were traffic accidents 48 cases (38%) and 73 cases (57.9%) were victims of blunt trauma. In 36 cases there was a politrauma. Hemo and/or pneumothorax represented the most common thoracic injury (85.7%). Rib fractures were present in 47 cases (36.2% with more than 3 rib fractures). Four patients sustained flail chest and 5 defect of thoracic wall. Six patients were pulmonary contusion and 8 intraparenchymal hematoma. Pleural drainage was performed in 106 cases (8 cases bilateral) and thoracotomy was indicated in 11 (6 cases emergency). Mortality was 6.9% (n:8), of which 4 belonged to politrauma group. Mortality is directly related with politrauma. In the patients of the chest trauma, aggressive diagnostic and therapeutic approaches in association with intensive care follow-up remains one of the most important points to decrease mortality and morbidity rate.
A Clinical Analysis of Patients Undergoing Fasciotomy Who Experienced the 2011 Van Earthquake
(Turkish Joint Diseases Foundation, 2012) Gormeli, Gokay; Gormeli, Cemile Ayse; Guner, Savas; Ceylan, Mehmet Fethi; Dursun, Recep
Objectives: This study aims to investigate the clinical profile and prognosis of the patients with fasciotomy who were admitted to Van Training and Research Hospital following the 2011 Van earthquake. Patients and methods: Twenty-one patients (11 males, 10 females; mean age 38.3 years; range 18 to 60 years) who had urgent fasciotomy in our clinic following the earthquake were included. Medical records including demographic data, clinical characteristics and prognostic data of the patients were retrospectively analyzed. Results: Seven of 21 patients with fasciotomies underwent amputation. Fasciotomy incisions were closed with skingrafting in nine patients and with primary closure in three patients. Eight patients had full range of motion of the joint, while four patients had restricted range of motion of the joint and needed rehabilitation. Two patients had sensory loss. Conclusion: Compartment syndrome is one of the serious problems after the Van earthquake. The infection ratio was low, while the amputation ratio was high. The use of anticoagulants following compartment syndrome worsens the clinical presentation, increasing the intracompartmental pressure.
Clinical and Laboratory Features of Patients With Pericardial Effusion
(2010) Gümrükçüoǧlu, H.A.; Akyol, A.; Tuncer, M.; Güneş, Y.; Beǧenik, H.; Akdaǧ, S.; Aǧirbaşli, M.
Objectives: We reviewed patients who were diagnosed to have pericardial effusion (PE) over a four-year period to determine the causes of PE, clinical and laboratory features, and treatment modalities. Study design: Medical records of 136 patients (81 women, 55 men; mean age 55.8±18.7 years; range 8 to 90 years) admitted to our department with PE from August 2005 to August 2009 were reviewed. The diagnosis of PE was made by transthoracic echocardiography. Medical history, physical examination, electrocardiography, echocardiography, and laboratory findings and treatment methods were recorded. Results: The most frequent complaint was dyspnea (86.8%) and the most common physical examination finding was jugular venous distension (47.1%). The most common electrocardiographic and echocardiographic findings were tachycardia (47.8%) and mild PE (<1 cm) (63.2%), respectively. Chronic renal failure and malignant diseases were the primary causes of PE (25% and 22.8% respectively), followed by idiopathic cases (14%). Pericardial tamponade was detected in 34 patients (25%), of which the majority had malignant diseases (53%). Thirty-eight patients (27.9%) underwent interventional treatment (pericardiocentesis in 27, surgical drainage in 11), while 98 patients (72.1%) were followed-up with medical treatment. Mortality occurred in three patients with pericardial tamponade. Conclusion: The most common causes of PE in our cases were chronic renal failure and malignancies. The incidence of malignant PE is on the incline owing to increased life expectancy. Echocardiography is the primary imaging modality for the evaluation of PE.
Clinical Results of Four Hundred and Twenty-Four Cases With Chest Trauma
(2003) Er, M.; Işik, A.F.; Kurnaz, M.; Cobanoglu, U.; Sagay, S.; Yalçinkaya, I.
BACKGROUND: In this retrospective study, we aimed to emphasize that thoracentesis is a fast and safe method to evaluate indication for thoracotomy in patients with thoracic trauma who have preshock or shock findings, without losing time by other examinations such as X - ray studies. METHODS: File records of 424 patients who were admitted to Thoracic Surgery Deparments of Adiyaman State Hospital and Medical School of Yuzuncu Yil University between December 1994 and March 2002, were investigated. RESULTS: There were 371(87,5%) male and 53 (12,5%) female patients, aged 5 to 89 (mean, 38,35). Most of the patients (n:382, 90%) were recovered by tube drainage and conservative management. There were 30 (7.1%) cases who underwent thoracotomy or median sternotomy. Nine patients underwent thoracotomy after being diagnosed by only thoracentesis without X - ray and 8 (89,9%) of them survived. The overall mortality was 2,8% (12 cases). CONCLUSION: Diagnostic thoracentesis has to be one of the indications for emergency thoracotomy after prompt systemic physical examination in the approach to thoracic trauma patient.
The Correlates of Healthcare Seeking Behavior in Obsessive-Compulsive Disorder
(Turkiye Sinir ve Ruh Sagligi dernegi, 2006) Besiroglu, Lutfullah; Agargun, Mehmet Yucel
Obsessive-compulsive disorder (OCD) is a chronic, distressing, and disabling illness that influences the family, academic, occupational, and social functioning of patients. One of the 10 leading causes of disability worldwide is OCD; however, despite the considerable distress and disability associated with the disorder and the availability of treatment options, many OCD sufferers usually are not inclined to seek healthcare. The factors that may be central to healthcare seek behavior in OCD has scarcely been described in the literature. It has been thought that the best predictor of healthcare seeking is severity of illness; however, individuals with OCD may have various barriers to seeking healthcare. Although non-disease and disease-related factors that may influence health care seeking are related in complex ways through reciprocal influences and feedback, each factor might be an independent predictor of use of healthcare services. This review aims to discuss the impact of the disease and general factors that impact healthcare seeking behavior in OCD. In this way, new information might be provided for the identification of targets to enhance the use of mental health services among OCD sufferers in the community.
Cystic Echinococcosis Seropositivity in the Blood Samples Sent To Parasitology Laboratory of Yüzüncü Yıl University Medical Faculty Between 2005 and 2013: Retrospective Assessment
(2015) Cengiz, Z.T.; Yılmaz, H.; Beyhan, Y.E.; Kotan M.Ç,; Çobanoğlu, U.; Ekici, A.; Ödemiş, N.
OBJECTIVE: This study was performed in order to contribute the data on the prevalence of cystic echinococcosis (CE) in Turkey and to reveal this parasitosis problem in Van province.; METHODS: Blood samples of 2642 patients (1214 men, 1428 women; 506 of them 0-13 age, 2136 of them 14 and over age group), which were sent with suspected CE to Parasitology Laboratory from various policlinics of Yüzüncü Yıl University Medical Faculty, between the dates of 01.09.2005 and 01.09.2013, were evaluated for CE by using Enzyme-Linked Immunosorbent Assay (ELISA) (R-Biopharm, Germany; IgG) method.; RESULTS: 801 (30.3%) of examined blood samples of these patients were found positive for this parasitosis. Seropositivity was found 31.9% of men, 29% of women; 33.4% of 0-13 age group, 29.6% of 14 and over age group in the study. Cysts, which were obtained from operated seropositive patients, were confirmed that unilocular cysts as pathological.; CONCLUSION: As a result, it was seen that CE is continued to be a major public health problem in Van province and it was appear that comprehensive protection and control programs should be carry out to struggle this disease.
Cytochrome Oxidase I Gene Sequences That Cause Hypodermosis Cattle Species by PCR-RFLP Technique Investigation
(2013) Oğuz, B.
Determination of Parasite Fauna of Chicken in the Van Region
(2009) Orunç, O.; Biçek, K.
The aim of this study was to determine the parasite fauna of the chicken in Van Province in 2002 and 2003. The material of the present study included endoparasites and ectoparasites determined by rutine parasitological examinations. Direct, flotation and sedimentation techniques for endoparasites were used. The total of endoparasites and ectoparasites were determined as 85% and 76% respectively. The ratios of endoparasites obtained from the chicken were coccidial oocystis 65%, Echinostoma spp. 2%, Davania proglottina 8%, Raillietina spp. 10%, Trichostrongylus tenuis 4%, Dispharynx nasuta 1%, Ascaridia galli 13%, Heterakis gallinarum 15%, Capillaria spp. 30% whereas ratios of ectoparasites were Goniocotes hologaster 32%, Lipeurus heteragraphus 6%, Eomenacanthus stramineus 42%, Menacanthus cornutus 11%, Menopon gallinae 22%.
Determination of the Status of Lipid Peroxidation and Antioxidants in Cattle Infected With Dictyocaulus Viviparus
(2008) Deǧer, S.; Deǧer, Y.; Ertekin, A.; Gül, A.; Biçek, K.; Ozdal, N.
Endoparasites cause significant economic losses and health problems in domestic animals. In this study, lipid peroxidation and the antioxidant status were investigated in the lung tissue taken from twenty cattle infected with Dictyocaulus viviparus and ten healthy cattle. Malondialdehyde superoxide dismutase, catalase, glutathione, vitamin C and beta-carotene were measured. In comparison to the control group, the concentration of MDA was high (p < 0.001), but the activities of Cu-Zn-SOD and CAT, and the concentration of GSH, vitamin C and beta-carotene were low (Cu-Zn-SOD, CAT, GSH, vitamin C, p < 0.001 and beta-carotene p < 0.05) in the parasite infected group. These results suggested that endoparasitic infection is among the major causes of oxidative stress. Lipid peroxidation was observed and the activities and concentrations of antioxidants systems were decreased in the lungs of cattle infected with Dictyocaulus viviparus.
Diagnostic Evaluation of Our Patients With Hemophilia A: 17-Year Experience
(Turkish Pediatrics Assoc, 2015) Karaman, Kamuran; Akbayram, Sinan; Garipardic, Mesut; Oner, Ahmet Fayik
Aim: Hemophilia A is a rare inherited bleeding disorder resulting from factor VIII deficiency and is a group of diseases characterized by intra-articular and intramuscular bleeding. In this study, we aimed to retrospectively evaluate the treatment outcomes, demographic and clinical characteristics of our patients who were treated and followed up for last 17 years in our pediatric hematology unit with a diagnosis of Hemophilia A. Material and Methods: The medical records of 83 patients who were diagnosed with Hemophilia A and followed up between 1997 and 2014 in our hospital's pediatric hematology clinic were reviewed retrospectively. The demographic data, prophylaxis state, development of inhibitors and clinical characteristics of the patients were evaluated. Results: When the complaints at presentation were examined, it was found that 27 (32%) patients had hemarthrosis, 24 (29%) patients had ecchymosis and hematoma, 13 (16%) patients had prolonged bleeding after trauma or cut, 10 (12%) patients had gingival, mouth or nose bleeding, 4 (5%) patients had prolonged bleeding after circumcision, 4 (5%) patients had gastrointestinal bleeding, 1 (1%) patient had hematuria. Fifty (60%) patients were considered severe hemophilia A, 20 (24%) patients were considered moderate hemophilia A and 13 (16%) patients were considered mild hemophilia A according to factor activity. Among severe hemophilia A patients, primary prophylaxis was being administered in 2 (2%) patients and secondary prophylaxis was being administered in 40 (48%) patients. Inhibitor positivity was found in 8 (10%) of these patients. It is found that hemophilic artropathy developed in 17 patients and 8 of these 17 patients had undergone radioisotope synovectomy. Conclusions: Treatment of severe bleeding in hemophilia A patients should be performed in hospital and the presence of inhibitor must be investigated in cases of uncontrolled bleeding where adequate doses of factor concentrates have been administered for treatment. In order to decrease the development of inhibitor, prophlaxis should be suggested to patients rather than repetetive treatment when bleeding occurs. The radioactive synovectomy should not be overlooked in countries like ours in which factors can not be used adequately.
Differences in Clinical and Histopathologic Features Between Chronic Adenotonsillitis and Chronic Adenotonsillar Hypertrophy
(2003) Kutluhan, A.; Ugraş, S.; Kiriş, M.; Cankaya, H.; Kiroglu, A.F.; Yurttaş, V.
OBJECTIVES: This study sought to determine the clinical and histopathological differences between chronic adenotonsillitis and chronic adenotonsillar hypertrophy. PATIENTS AND METHODS: This prospective study included 286 patients (147 males, 139 females; mean age 16.6 years; range 3 to 45 years) with chronic adenotonsillitis and 197 patients (98 males, 99 females; mean age 9.5 years; range 2 to 18 years) with adenotonsillar hypertrophy. Clinical and histopathological findings were compared. RESULTS: The mean age was significantly higher (p<0.001) and acute attacks of fever, dysphagia, and sore throat were more frequent in chronic adenotonsillitis. Patients with adenotonsillar hypertrophy more commonly manifested snoring, mouth breathing, and dispnea. Physical examination showed hyperemia of the anterior plica in 93% and 15% in chronic adenotonsillitis and adenotonsillar hypertrophy, respectively. Histopathologically, the former was more commonly associated with severe lymphocyte infiltration to surface epithelium, surface epithelial defects, plasma cells, atrophy, and fibrosis. The sole outweighing difference in favor of chronic adenotonsillar hypertrophy was increased germinal centers. CONCLUSION: Clinical and histopathologic findings suggest that chronic adenotonsillitis and chronic adenotonsillar hypertrophy may be diverse diseases requiring different approaches in treatment.
Distribution of Blaoxa Genes in Acinetobacter Baumannii Strains: a Multicenter Study
(Ankara Microbiology Society, 2013) Çiftci, I.H.; Aşik, G.; Karakeçe, E.; Öksüz, L.; Yaǧci, S.; Sesli Çetin, E.; Ayyildiz, A.
Acinetobacter baumannii is the most important agent of nosocomial infections within the Acinetobac-ter genus. This gram-negative coccobacillus is intrinsically resistant to many antibiotics used in antimicrobial therapy, and capable of developing resistance including carbapenems. The objective of this study was to develop a multiplex real time polymerase chain reaction (qPCR) kit for OXA subgroups in A.ba-umannii, and to investigate the distribution of OXA subgroups in A.baumannii strains isolated from geographically different regions of Turkey. A total of 834 A.baumannii clinical isolates collected from different state and university medical centers in 13 provinces (Afyonkarahisar, Ankara, Bolu, Elazig, Erzurum, Isparta, Istanbul, Kahramanmaras, Konya, Sakarya, Van) between 2008-2011, were included in the study. The isolates were identified by conventional methods and automated systems [Vitek2 (bioMeri-eux, ABD) and Phoenix (BD Diagnostic, MD)]. The susceptibility profiles of the isolates were studied with automated systems and standard disc diffusion method. All samples were subjected to qPCR to detect blaOXA-51-like, bla OXA-23-like, and blaOXA-58-like, genes. conventional PCR method was also used to detect blaOXA-24-like, gene. The resistance rates observed during the study period were as follows: 96.8% for amo-xicillin-clavulanate, 86.8% for ciprofloxacin, 74.7% for gentamicin, 71.7% for amikacin, 73.5% for ce-faperozone-sulbactam, 72.1% for imipenem and 73% for meropenem. Six hundred and two (72.2 %) isolates were resistant to both imipenem and meropenem. Colistin was found to be the most effective antibiotic against A. baumannii isolates with 100% susceptibility rate. All isolates were positive for blaOXA-51-like, gene, however blaOXA-24-like, gene could not be demonstrated in any isolate. Total positivity rates of bla OXA-23-like and blaOXA-58-like genes were found as 53.7% and 12.5%, respectively, while these rates were 74.4% and 17.3% in carbapenem-resistant isolates, respectively. Twenty-five isolates were positive for both blaOXA-23-like and blaOXA-58-like genes. All of the carbapenem-resistant isolates have OXA type genes with the exception of blaOXA-24-like gene. The positivity rates for bla OXA-23-like and blaOXA-58-like genes varied for each center. In addition, there was a decrease in the frequency of bla OXA-58-like gene, however both blaOXA-23-like gene and carbapenem resistance rates increased during the study period. In conclusion, high rates of resistance to carbapenems were also remarkable but Abaumannii strains keep on sensitivity to Colistin. Both blaOXA-23-like and blaOXA-58-like genes were shown to be widespread in carbapenem-resistant A.baumannii clinical isolates. However, bla OXA-23-like gene positive strains were increased throughout the study. Currently, multiplex qPCR is the best way for rapid diagnosis of resistant bacteria for prevention of hospital-acquired infections. The multiplex qPCR kit developed in this study could be useful for rapid diagnosis and identify the frequencies of blaOXA-23-like blaOXA-51-like and blaOXA-58-like genes in carbapenem-resistant A.baumannii clinical isolates.

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