Van Yüzüncü Yıl Üniversitesi

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Changes in Certain Biochemical Parameters of Arterial Blood and Cerebrospinal Liquor of Sheep Anaesthetised by Isoflurane and Halothane
(Mezogazda Kiado Kft, 2004) Mercan, N; Atasoy, N; Gençcelep, M; Tas, A
The authors performed biochemical examinations of twenty sheep's arterial blood and cerebrospinal liquor (CSL) to establish the changes caused by inhalation anaesthetics (halothane and isoflurane). Ten animals were anaesthetised by isoflurane (1.5 v/v%) and ten of them by halothane (1 v/v%). Blood samples were taken from a. femoralis and the CSL samples by lumbosacral punction before the anaesthesia (BA), during anaesthesia (DA) and after anaesthesia (AA). From the blood samples pH, pCO(2), pO(2) SAT and HCO3 ion and from the CSL glucose, Na, K and Cl ion-concentration were measured. There were no significant changes (p>0.05) during isoflurane narcosis except CSL glucose content, which was significant (p<0.05). During halothane narcosis pCO(2) and pO(2) DA (p<0.01), HCO3 ion DA (p<0.001), and AA (p<0.05) changed significantly. The results show that sheep tolerate isoflurane better than halothane, because isoflurane did not have unfavourable effects on blood and CSL parameters.
D-Dimer Level as a Potential Marker of Cutaneous Disease Activity in Canine Leishmaniosis and Demodicosis
(Herman Otto Intezet, 2020) Ayan, A.; Ural, K.; Erdoǧan, H.; Gültekin, M.
Biochemical markers for detecting disease activity allow a clinician to monitor severity of illness, progression, and response to therapy. D-dimer is a breakdown/degradation product of cross-linked fibrin, increasing with clot formation and fibrinolysis and its testing is non-invasive. The aim of this study was to measure D-dimer concentrations and assess their value in the diagnosis of cutaneous disease activity in dogs with canine visceral leishmaniosis (CVL) and demodicosis, besides the strengths of the latter marker in identifying early diagnosis. D-dimer analyses were performed in two groups of dogs; (ll) 13 dogs with CnVL, (III) 16 dogs with demodicosis, then were compared to those of healthy dogs (n = 11) as (l) control group. The D-dimer range in clinically healthy dogs was < 0.1 mg/L. In dogs with CVL and demodicosis, the D-dimer concentrations were higher than those of healthy dogs (p < 0.05) and (p < 0.01), respectively. In both groups, D-dimer level increased with clinical evidence of disease. D-dimer concentration may be considered as an indicator for cutaneous disease activity during selected diseases and may be useful as a potential biochemical marker of disease activity in certain cutaneous inflammatory conditions. © 2020 Herman Otto Intezet. All rights reserved.
The Effects of Inhalation Anaesthetics Made With Halothane and Isoflurane on Some Biochemical Parameters in Sheep
(Mezogazda Kiado Kft, 2002) Atasoy, N; Gündüz, H; Gençcelep, M; Karakaya, C; Mercan, N
This study was undertaken to determine the effects of halothane and isoflurane on the functions of different organs. A total of 20 sheep were used as material. Ten of them were anaesthetized with halothane (1%) and the other 10 with isoflurane (1.5%). Blood samples were taken from v. jugularis before (BA), during (DA) and after anaesthesia (AA). Sera were collected and analysed for glucose, BUN, creatinine, total bilirubin, AST, ALT, amylase, LDH, CK, CK-MB, ALP, Ca, Na, K and Cl. The effects of the anaesthetics on the parameters were evaluated statistically. These parameters did not change significantly in isoflurane anaesthesia (p>0.05), but in halothane anaesthesia glucose (DA) (p<0.05), creatinine (AA) (p<0.01) and AST (AA) (p<0.05) levels changed significantly. It was concluded that isoflurane can be tolerated better than halothane by sheep and its application did not have destructive effects on the metabolism of pancreas, kidney, liver and muscle.

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