Placental Pathologic Features in Preeclampsia and Normal Pregnancies

Abstract

AIM: The objective was to evaluate placental pathologic features in normal and preeclamptic pregnancies. STUDY DESING: Eighty-three preeclamptic-eclamptic and 30 control pregnant women without systemic disease between October 2001 and September 2002 were prospectively recruited. Placental pathologies were evaluated due to macroscopic findings and nine histological parameters on light microscope. Statistics included student t test and chi-square test. RESULT(s): Increased syncytiotrophoblast knotting, cytotrophoblast proliferation, focal perivillous fibrin deposition, villous stromal fibrosis, fibrinoid necrosis, maturation, basal membrane thickening, mineralization in basal membrane and villous stromal edema were more common in the study group compared to the control group. Fibrinoid necrosis in uteroplacental vessels, villous stromal fibrosis, mineralization in basal membrane and villous stromal edema were not seen in any patient in the control group. CONCLUSION: Placental pathologic features play an important role in the pathophysiology of preeclampsia.