Agar and Sesame Oil Based Organo-Hydrogels as a Pharmaceutical Excipient in Paracetamol/Carboplatin Release Systems

Abstract

Organo-hydrogels were synthesized by using free radical polymerization in the emulsion technique, using agar, glycerol, sesame oil, ammonium persulfate as initiator and N,N'-methylene bisacrylamide or glutaraldehyde as crosslinker. Swelling behaviors, blood compatibility, antioxidant and properties of the organo-hydrogels were investigated thoroughly. The highest swelling value was seen in organo-hydrogel synthesized with the N,N'-methylene bisacrylamide crosslinker containing 0.1 ml of sesame oil. Moreover, drug release behaviors of organo-hydrogels were studied as paracetamol and carboplatin used as model drugs. Release studies were shown that some basic parameters such as medium pH and composition of the polymer structure affect organo-hydrogels drug release behavior. As a result of drug release experiments, it was observed that the release values of organo-hydrogels changed depending on sesame oil and crosslinker content. The highest paracetamol release capacities for the p (AG-m-SO)(2) and p (AG-g-SO)(2) organo-hydrogels were calculated as 45.3 % and 79.8 %. When investigated carboplatin releases, the highest releases also were founded to be 100 % for p (AG-m-SO)(2) and 85 % for p (AG-g-SO)(2).