Effects of Epigallocatechin Gallate Administration on Diabetic Rat Myocardial Tissue

Abstract

This study aimed to investigate the actions of Epigallocatechin Gallate (EGCG) on heart tissue in diabetic rats. In the study, twenty-eight Wistar albino male rats were taken and divided into 4 groups as control group, EGCG, Diabetes, and Diabetes + EGCG. A one dose of 45 mg/kg streptozotocin (STZ) was administered intraperitoneally to the groups to be described with diabetes. EGCG was given to the animals at 20 mg/kg/day for 14 days using an intragastric tube. The heart tissue was stained with Masson trichrome and Hematoxylin-Eosin (H&E). Heart tissue was evaluated by histopathological and immunohistochemical (Collagen type III) methods. In the histological structure of the diabetic group, irregular heart muscle fibers, inflammatory cell infiltration, and necrotic myocytes in the myocardium an d increased collagen type III expression were observed, and these findings were found to decrease in the Diabetes + EGCG group. It was found that the density of collagen content increased in the Diabetes group. This finding decreased in the Diabetes + EGCG g roup. The findings of our study suggest that EGCG may have ameliorative effects on induced cardiotoxicity in diabetic rats. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.