Platelet Indices in Graves Disease, Especially Plateletcrit

Abstract

Graves’ disease is an autoimmune thyrotoxicosis caused by thyroid receptor antibody and occurs in 1% of the population. Autoimmune events develop against cells invarious tissues, including platelets. Platelet lymphocyte interaction can regulate these events. We investigated this relationship in our study. We compared leukocyte andplatelet indices in 66 Graves patients and 38 control patients from hemogram parameters prospectively. Lymphocyte count, neutrophil count, platelet lymphocyte ratio,neutrophil lymphocyte ratio was insignificant between the two groups (p: 0.51, 0.13, 0.19, 0.097, respectively). Platelet count, PDW and PCT were significantly higherin Graves patients (p: 0.02, 0.03, 0.00, respectively), and MPV was significantly lower (p: 0.007). In the ROC curve analysis, the PCT threshold value was 0.24. Plateletindices in graves patients and especially PCT were more correlated with the disease than other hemogram parameters. This finding may help to clarify the pathogenesisof the disease.