The Effects of Inhalation Anaesthetics Made With Halothane and Isoflurane on Some Biochemical Parameters in Sheep

Abstract

This study was undertaken to determine the effects of halothane and isoflurane on the functions of different organs. A total of 20 sheep were used as material. Ten of them were anaesthetized with halothane (1%) and the other 10 with isoflurane (1.5%). Blood samples were taken from v. jugularis before (BA), during (DA) and after anaesthesia (AA). Sera were collected and analysed for glucose, BUN, creatinine, total bilirubin, AST, ALT, amylase, LDH, CK, CK-MB, ALP, Ca, Na, K and Cl. The effects of the anaesthetics on the parameters were evaluated statistically. These parameters did not change significantly in isoflurane anaesthesia (p>0.05), but in halothane anaesthesia glucose (DA) (p<0.05), creatinine (AA) (p<0.01) and AST (AA) (p<0.05) levels changed significantly. It was concluded that isoflurane can be tolerated better than halothane by sheep and its application did not have destructive effects on the metabolism of pancreas, kidney, liver and muscle.