Transforming Growth Factor Beta-1 in Human Colorectal Cancer Patients
| dc.contributor.author | Kemik, O. | |
| dc.contributor.author | Kemik, A.S. | |
| dc.contributor.author | Purisa, S. | |
| dc.contributor.author | Hasirci, I. | |
| dc.contributor.author | Dülger, A.C. | |
| dc.contributor.author | Adaş, M. | |
| dc.contributor.author | Tüzün, S. | |
| dc.date.accessioned | 2025-05-10T17:07:05Z | |
| dc.date.available | 2025-05-10T17:07:05Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Aim: Colorectal cancer patients are treated with surgery and sometimes radiotherapy and chemotherapy. Transforming growth factor beta-1 (TGF-β1) acts both as an inhibitor of tumor growth and as a promoter of tumor progression. The aim of this study was to determine the levels of TGF-β1 in plasma in colorectal cancer patients and relate these to the effect of clinicopathological variables. Method: One hundred patients scheduled for colorectal cancer surgery were included. Blood samples were taken during surgery and later assayed with enzyme linked immunsorbent assay for total TGF-β1 and active TGF-β1. Result: Total and active TGF-β1 was higher in tumor samples compared to controls (p<0.001).Total TGF-β1 was higher in patients with metastases compared to patients without. Active TGF-β1 levels were not found statistically different in patients with metastases. Conclusion: Higher levels of total TGF-β1 in plasma at surgery may be indicate of distant metastases, Measurement of total TGF-β1 in colorectal cancer patients may be of clinical use in the future. | en_US |
| dc.identifier.doi | 10.29333/ejgm/82697 | |
| dc.identifier.issn | 1304-3889 | |
| dc.identifier.scopus | 2-s2.0-79956369765 | |
| dc.identifier.uri | https://doi.org/10.29333/ejgm/82697 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6641 | |
| dc.language.iso | tr | en_US |
| dc.publisher | TIP ARASTIRMALARI DERNEGI | en_US |
| dc.relation.ispartof | European Journal of General Medicine | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Colorectal Cancer | en_US |
| dc.subject | Distant Metastases | en_US |
| dc.subject | Tgf-Beta-1 | en_US |
| dc.title | Transforming Growth Factor Beta-1 in Human Colorectal Cancer Patients | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.scopusid | 6504566099 | |
| gdc.author.scopusid | 35332340400 | |
| gdc.author.scopusid | 6504310163 | |
| gdc.author.scopusid | 36477329400 | |
| gdc.author.scopusid | 36476941100 | |
| gdc.author.scopusid | 19033400300 | |
| gdc.author.scopusid | 19033400300 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | Kemik O., Yuzuncu Yil University Medical Faculty, Department of General Surgery, Van, Turkey; Kemik A.S., Department of Gastroeneterology, Van, Turkey; Purisa S., Istanbul University, Cerrahpasa Medical Faculty, Departments of Biochemistry, Istanbul, Turkey; Hasirci I., Yuzuncu Yil University Medical Faculty, Department of General Surgery, Van, Turkey; Dülger A.C., Departments of Biostatisc, Istanbul, Turkey; Adaş M., Okmeydani Training Hospital, Department of Endocrinology, Istanbul, Turkey; Tüzün S., Haseki Training Hospital, II. General Surgery, Istanbul, Turkey | en_US |
| gdc.description.endpage | 56 | en_US |
| gdc.description.issue | 1 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | N/A | |
| gdc.description.startpage | 53 | en_US |
| gdc.description.volume | 8 | en_US |
| gdc.description.wosquality | N/A | |
| gdc.index.type | Scopus |