The Effects of Epinephrine, Norepinephrine and Dopamine on Hemogram and Coagulation Parameters

Abstract

Abstract Introduction: Vasopressor agents stimulate endothelial cells and platelets via the sympathetic nervous system and affect the coagulation cascade through various mediators. This study aimed to investigate the effects of epinephrine, norepinephrine, and do pamine on hemogram and coagulation parameters. Materials and Methods: A total of 28 healthy Wistar albino rats weighing 250-300 grams were used in this study. The rats were randomly divided into four groups, with 7 in each group. 0.9 % serum physiologic ( group C, n=7), epinephrine (group E, n=7), norepinephrine (group NE, n= 7), dopamine (group D, n=7) were intraperitoneally perfused to the rats under sedation. Blood samples were draw n from the rats 30 minutes after perfusion. Hemogram and coagulation para meters were compared between the groups. Results: Granulocyte values were lower in the dopamine group. Platelet cluster count was higher in the dopamine group. The highest hemoglobin and hematocrit values measured among the groups were observed in Group E, and its values were higher than those in the norepinephrine and control groups. Conclusion: It has been determined that vasopressor drugs affect hemogram values and platelet aggregation in different ways, but do not cause any changes in coagulation parameters.