A Case of Isolated Cns Relaps With Atipik Clinical Presentation in an Acute Myeloblastic Leukemia Patient

Abstract

After the recent advances in chemotherapy and supportive care, survival and the number of extrameduller relaps have increased in childhood acute myeloblastic leukemia (AML). However isolated central nervous system (CNS) relaps is a rare event in AML. We reported a 7 years old child, who presented with dyspnea, diagnosed isole CNS relaps at the 30th week of maintance chemotherapy protocol of AML. He admitted to our emergency service with the complain of dispne. Respiratory track infection or other pathology was not found on phsycal examination and labaratuary tests. On follow up, lumbar puncture was performed to the patient having no any improvement in dispne to evaluate the CNS disorders. Cerebro spinal fluid examination showed a lot of blastic cell and thus isolated CNS relaps was diagnosed. Cranial MRI showed an enlargement at pons and bulbus corresponding leukemic infiltration. Dispne were resolved just after the beginning of administration intratechal and systemic reinduction chemotherapy.