Biomedical Potential of P(Rt) Particles Synthesized from Rubia Tinctorum L. Extract: Characterization, Bioactivity and Controlled Drug Release

Abstract

Rubia tinctorum L. (Root Dye, Madder) has been historically used in textile dyeing and is valued for its natural antibacterial, antioxidant, and therapeutic properties. In this study, the synthesis of poly(Rubia tinctorum) (p(Rt)) particles from Rubia tinctorum L. extract and their biomedical applications are reported for the first time. The extract and synthesized particles were characterized using SEM, FTIR, DLS, zeta potential analysis, and HPLC. The bioactivity of p(Rt) particles, including antimicrobial, antioxidant, and biocompatibility properties, were assessed. Drug release studies showed significant paracetamol and ceftriaxone release at different pH levels, with release kinetics fitting the Korsmeyer-Peppas model. This study highlights the novelty of p(Rt) particles and their potential in biomedical applications, particularly in drug delivery.