Evaluation of Platelet Distribution Width(PDW) and Mean Platelet Volume(MPV) in Patients With Obstructive Sleep Apnea Syndrome(OSAS): A Retrospective Clinical Study

Abstract

This study aimed to evaluate the association between PDW and MPV with Obstructive Sleep Apnea Syndrome (OSAS). The study’s design is a retrospective evaluation of OSAS patients admitted to our pulmonology department between January 2022 and June 2024. The data and clinical-laboratory parameters of patients diagnosed with polysomnography were evaluated. The PDW and MPV measurements were retrieved from the complete blood counts’ of the patients. OSAS patients were divided into three groups according to the Apnea-hypopnea Index(AHI) score as mild, moderate and severe OSAS. Healthy subjects with no known chronic disease admitted to our outpatient clinic were enrolled as control group. In total, 140 patients with OSAS and 120 healthy subjects as control group were included in the study. The OSAS groups consisted of as 60 mild, 45 moderate, and 35 severe. The mean age of OSAS group and control group were as 51.8 12 and 47.611, respectively which was not statistically significant. There was statist ically significant difference between OSAS and control group with respect to the BMI(31.85.0 vs 26.44.2, p:0.01). The male/female patients were 96/44 in OSAS and 86/34 in control group which was not statistically different (p:0.04). The mean PDW and MPW were 18.82.5 and 10.71.2 in OSAS group. The mean PDW and MPV were 14.61.7 and 7.82.4 in control group. There was statistically significant difference between OSAS and control group with respect to mean PDW and MPV values (p:0.02 and p:0.01). The subgroup analysis showed that MPV increased statistically significant as OSAS severity got impaired. This study showed that increased PDW and MPV was associated with OSAS and also the activation of platelets has potential effect on the severity of OSAS.