Effects of Xylazin on Sedative, Analgesic and Some Liver Enzymes in Rats

Abstract

This study was conducted to determine the sedation level of rats after using two different doses of Xylazine, to measure the damage that may occur in the liver, and to determine the change in pain response due to sedation. The use of analgesic substances is one of preferred methods in pain control studies. Analgesic effects are also present in drugs used for sedative purposes. Xylazine is used for pain relief, calming (sedative), sleep inducing (hypnotic), and striated muscle relaxation. It is also used for premedication purposes before using different anesthetic drugs. 24 rats used in the study were randomly selected and divided into three groups. Only physiological saline was given to the rats in the control group (KO). The second group was given Xylazine (K10) 10 mg/kg intraperitoneally (ip), and the third group was given Xylazine (K15) 15 mg/kg/ip. Sedation assessment was performed according to the behavior of the rats to which sedative drugs were applied to the stimuli. Sedation was classified as mild, moderate and severe. The degree of pain-relieving properties of Xylazine in rats was measured with a pain test. The pain test was performed with a hotplate test and a hotplate apparatus. After the pain tests, the rats were sacrificed after taking blood as needed. AST, ALT and corticosteroid values were measured in the blood serum. In this study, it was determined that Xylazine had pain-relieving properties and did not change liver enzyme values when used at a dose of 15 mg/kg in rats, and it was concluded that it could be preferred for safe sedation in cases where short-term complete immobility was needed. © (2024), (Universidad del Zulia). All Rights Reserved.