YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Evaluation of Immunoglobulin Levels in Children Aged 1-5 Years With Recurrent Lower Respiratory Tract Infections

dc.authorscopusid 56705479600
dc.authorscopusid 57201451804
dc.authorscopusid 6603596874
dc.contributor.author Aycan, N.
dc.contributor.author Sazak, S.
dc.contributor.author Samanci, N.
dc.date.accessioned 2025-05-10T16:54:43Z
dc.date.available 2025-05-10T16:54:43Z
dc.date.issued 2023
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Aycan N., Department of Pediatrics, Yuzuncu Yil University, Van, Turkey; Sazak S., Department of Pediatrics, Prof. Dr. Cemil Tascıoglu City Hospital, Istanbul, Turkey; Samanci N., Department of Pediatrics, Namik Kemal University, Tekirdag, Turkey en_US
dc.description.abstract Immunodeficiency plays a crucial role in the etiology of recurrent pneumonia. Humoral immunodeficiencies account for approximately 60% of all primary immunodeficiencies, and in such patients, antibody deficiencies are the leading cause of immunodeficiency. That study aimed to investigate the effect of immunoglobulin levels on the frequency of pneumonia episodes and the relationship between immunoglobulin levels and risk factors for pneumonia in children aged 1-5 years with recurrent pneumonia caused by humoral immunity. The prospective study included a total of 92 randomly selected children aged 1-5 years, comprising a group of 70 patients hospitalized due to pneumonia and a group of 22 healthy controls who had no chronic diseases and infections. Body height and weight were significantly lower in the patient group compared to the control group (p=0.012 and p=0.022, respectively). The mean breastfeeding duration was significantly lower (p=0.001), and the prevalence of exposure to environmental tobacco smoking (ETS) was significantly higher (p=0.018) compared to the control group. In the patient group, 65% of the participants had a deficiency of an immunoglobulin isotope and/or IgG subclasses in isolation or combination. IgG4 deficiency was the most common deficiency (38.5%), followed by IgG1 (21.4%), IgG2 (18.5%), IgA (15.7%), and IgG3 deficiency (12.8%), respectively. Our results indicated that inadequate breastfeeding and environmental tobacco smoking prepare the ground for pneumonia, a significant cause of morbidity and mortality in children, and contributes to the recurrence of this disease. Humoral immunodeficiencies, a significant underlying cause of recurrent pneumonia that leads to growth retardation, may have different clinical manifestations. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. en_US
dc.identifier.doi 10.5505/ejm.2023.35033
dc.identifier.endpage 491 en_US
dc.identifier.issn 1301-0883
dc.identifier.issue 3 en_US
dc.identifier.scopus 2-s2.0-85166008372
dc.identifier.scopusquality Q4
dc.identifier.startpage 484 en_US
dc.identifier.trdizinid 1263259
dc.identifier.uri https://doi.org/10.5505/ejm.2023.35033
dc.identifier.uri https://hdl.handle.net/20.500.14720/3216
dc.identifier.volume 28 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Yuzuncu Yil Universitesi Tip Fakultesi en_US
dc.relation.ispartof Eastern Journal of Medicine en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Childhood en_US
dc.subject Humoral Immune Deficiency en_US
dc.subject Recurrent Lower Respiratory Tract Infection en_US
dc.title Evaluation of Immunoglobulin Levels in Children Aged 1-5 Years With Recurrent Lower Respiratory Tract Infections en_US
dc.type Article en_US

Files