Chitosan-Based Ph-Sensitive Antibacterial Bionanocomposites With Laponite Immobilized Silver Nanoparticles for Delivery of Sunitinib Maleate To Breast Cancers

Abstract

In this work, new pH-sensitive and antibacterial drug carrier systems based on silver nanoparticles (AgNPs) embedded in the interlayer of laponite (Lap) in the presence of chitosan (CTS) for the controllable release of sunitinib maleate (STM) were developed. Silver ions and sunitinib maleate were first loaded into Lap, and the CTS-based hybrid bionanocomposite carrier (Lap@CTS@AgNPs@STM) was obtained in the presence of citric acid as a cross-linker agent. The successful preparation of nanocarrier and Ag NPs formation was thoroughly confirmed using techniques such as FTIR, XRD, TGA, SEM, and TEM. TEM images illustrated the excellent distribution of Ag NPs in the structure of Lap@CTS@AgNPs. The as-prepared samples showed a pH-sensitive anticancer drug release behavior. The STM release mechanism was studied using Korsmeyer-Peppas and Higuchi kinetic models. Furthermore, the in vitro cytotoxicity and antibacterial tests were carried out against both bacteria S. aureus and E. coli and MCF-7 cell lines, respectively, to prove the effectiveness of synthesized samples as multifunctional carrier systems for biomedical applications. An effective pH-sensitive antibacterial single nanoformulation based on chitosan with laponite incorporated silver nanoparticles for anticancer drug delivery to the breast cancer was successfully developed. image