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Prognostic Value of Pulmonary Artery Diameter/Aorta Diameter Ratio in Patients With Acute Pulmonary Embolism

dc.authorid Yumurtas, Ahmet Cagdas/0000-0002-7311-2826
dc.authorid Keskin, Kivanc/0000-0001-7005-4184
dc.authorwosid Tezen, Ozan/Glu-2308-2022
dc.authorwosid Hayiroglu, Mert/Aaq-3365-2021
dc.authorwosid Kolak, Zeynep/Gxf-6851-2022
dc.authorwosid Cetin, Tugba/Mfj-7247-2025
dc.authorwosid Cinar, Tufan/Abd-4630-2020
dc.authorwosid Yumurtaş, Ahmet/Jac-4458-2023
dc.authorwosid Pay, Levent/Adr-2591-2022
dc.contributor.author Pay, Levent
dc.contributor.author Cetin, Tugba
dc.contributor.author Keskin, Kivanc
dc.contributor.author Dereli, Seyda
dc.contributor.author Tezen, Ozan
dc.contributor.author Yumurtas, Ahmet Cagdas
dc.contributor.author Hayiroglu, Mert Ilker
dc.date.accessioned 2025-05-10T17:22:57Z
dc.date.available 2025-05-10T17:22:57Z
dc.date.issued 2024
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Pay, Levent] Ardahan State Hosp, Dept Ophthalmol, TR-75000 Ardahan, Turkiye; [Cetin, Tugba; Keskin, Kivanc; Dereli, Seyda; Kolak, Zeynep; Eren, Semih; Hayiroglu, Mert Ilker] Dr Siyami Ersek Thorac & Cardiovasc Surg Training, Dept Cardiol, Istanbul, Turkiye; [Tezen, Ozan] Bayrampasa State Hosp, Dept Cardiol, Istanbul, Turkiye; [Yumurtas, Ahmet Cagdas] Kars Harakani State Hosp, Dept Cardiol, Kars, Turkiye; [Saylik, Faysal] Van Educ & Res Hosp, Dept Cardiol, Van, Turkiye; [Cinar, Tufan] Univ Maryland, Med Ctr, Dept Med, Midtown Campus, Baltimore, MD USA en_US
dc.description Yumurtas, Ahmet Cagdas/0000-0002-7311-2826; Keskin, Kivanc/0000-0001-7005-4184 en_US
dc.description.abstract BackgroundThe ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.MethodsA total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.ResultsLong-term mortality was observed in 48 patients during the median follow-up of 59 (39-73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544-7.3436, p = 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively, p = 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.ConclusionsThe PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients. HintergrundDas Verh & auml;ltnis zwischen dem Pulmonalarteriendurchmesser (PAD) und dem Durchmesser der Aorta ascendens (AoD) wurde als prognostischer Marker f & uuml;r verschiedene Lungenerkrankungen beschrieben; sein Nutzen bei Patienten mit akuter Lungenembolie (LE) ist jedoch nicht bekannt. Ziel der vorliegenden Arbeit war es, den prognostischen Langzeitwert des PAD-AoD-Quotienten bei Patienten mit LE zu ermitteln.MethodenZwischen November 2016 und Februar 2022 wurden 275 Patienten mit der Diagnose einer LE im Terti & auml;rversorgungszentrum der Autoren in die Studie eingeschlossen. Dabei wurden die Patienten entsprechend dem Vorliegen von Langzeitmortalit & auml;t in 2 Gruppen eingeteilt und ihre PAD-AoD-Quotienten verglichen.ErgebnisseLangzeitmortalit & auml;t wurde bei 48 Patienten w & auml;hrend des mittleren Follow-up von 59 (39-73) Monaten festgestellt. Zur Auswertung wurden die Patienten in 2 Gruppen unterteilt: Gruppe 1, bestehend aus 227 Patienten ohne dokumentierte Mortalit & auml;t, und Gruppe 2, bestehend aus 48 Patienten mit dokumentierter Mortalit & auml;t. Ein multivariates Cox-Regressions-Modell ergab, dass der PAD-AoD-Quotient das Potenzial aufweist, die Langzeitmortalit & auml;t vorherzusagen (Hazard Ratio, HR: 2,9116; 95%-Konfidenzintervall, 95%-KI: 1,1544-7,3436; p = 0,023). Die Analyse der Receiver-Operating-Characteristic-Kurve zeigte, dass es keinen erkennbaren Unterschied in der Unterscheidungsf & auml;higkeit zwischen dem Simplified Pulmonary Embolism Severity Index (sPESI) und dem PAD-AoD-Quotienten gab (,,area under the curve" [AUC] = 0,679 vs. 0,684; p = 0,937). Die langfristige Vorhersagekraft des PAD-AoD-Quotienten war dem sPESI-Score nicht unterlegen.SchlussfolgerungDer PAD-AoD-Quotient, der einfach anhand der Computertomographie der Lunge errechnet werden kann, ist m & ouml;glicherweise ein n & uuml;tzlicher Parameter zur Ermittlung der Prognose von Patienten mit LE. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1007/s00059-024-05251-4
dc.identifier.endpage 471 en_US
dc.identifier.issn 0340-9937
dc.identifier.issn 1615-6692
dc.identifier.issue 6 en_US
dc.identifier.pmid 38832941
dc.identifier.scopusquality Q3
dc.identifier.startpage 464 en_US
dc.identifier.uri https://doi.org/10.1007/s00059-024-05251-4
dc.identifier.uri https://hdl.handle.net/20.500.14720/10726
dc.identifier.volume 49 en_US
dc.identifier.wos WOS:001238571300001
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Urban & Vogel en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Acute Pulmonary Embolism en_US
dc.subject Ascending Aortic Diameter en_US
dc.subject Computed Tomography en_US
dc.subject Pulmonary Arterial Diameter en_US
dc.subject Pulmonary Artery To Aorta Ratio en_US
dc.subject Akute Lungenembolie en_US
dc.subject Durchmesser Aorta Ascendens en_US
dc.subject Computertomographie en_US
dc.subject Lungenarteriendurchmesser en_US
dc.subject Verh & Auml en_US
dc.subject Ltnis Von Lungenarterie Zu Aorta en_US
dc.title Prognostic Value of Pulmonary Artery Diameter/Aorta Diameter Ratio in Patients With Acute Pulmonary Embolism en_US
dc.type Article en_US

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