Investigation of the Lipid Peroxidation, Antioxidant Substances, Antioxidant Vitamins and Some Hematologic-Biochemical Parameter Levels in Gentamycine Induced Nephrotoxicosis in Dogs

Abstract

In our study, malondialdehyde, antioxidant vitamins, antioxidant substances and some hematologic-biochemical parameter levels in nephrotoxicosis were investigated. Six dogs were used in the study. Blood samples taken before the experiment were used as the control. Blood samples were taken on days 2, 5, 7 and 10 during the experiment. During analysis, we found that the statistical changes were not significant in the retinol and Vitamin C levels of the experiment group when compared to those of the control group. beta-carotene (P < 0.05) and Vitamin E (P < 0.001) levels were significantly decreased. Increases in the levels of malondialdehyde, seruloplasmin and urine gamma-glutamyl transferase (GGT) enzyme were P < 0.001, while decreases in the amounts of glutathione were P < 0.001. We also found that changes in erythrocyte and hemotocrit levels were not significant. On the other hand, increases in the levels of leucocyte (P < 0.01), creatinin and blood urea nitrogen (BUN) P < 0.001 were significant. In conclusion, oxidative damage can occur in cells in nephrotoxicosis, the use of antioxidants could be of benefit during treatment with chemotherapeutics.