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Effect of Intermittent Fasting on Sciatic Neurofilaments in Acrylamide Administered Rats

dc.authorscopusid 57206429841
dc.contributor.author Oğuz, E.K.
dc.date.accessioned 2025-05-10T17:01:29Z
dc.date.available 2025-05-10T17:01:29Z
dc.date.issued 2018
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Oğuz E.K., Department of Science Education, Van Yüzüncü Yıl University, Van, 65080, Turkey en_US
dc.description.abstract Acrylamide is a widely used chemical in industrial manufacturing and laboratory studies. Long term use of this chemical causes axonal degeneration. In this study, 20 mg/kg of acrylamide was administered to Wistar-albino rats daily and effects on sciatic nerve and any potential protective activity of intermittent fasting were investigated. Effect of acrylamide and intermittent fasting was assessed by immunefluorescent method. As a result paralysis in hind legs and coordination problems during walking was observed in acrylamide administered group. These problems were less frequent in intermittent fasting group. In addition, a decrease in neurofilament number was observed in acrylamide group whereas neurofilament level was similar with control group in intermittent fasting group. Concomitant administration of acrylamide and intermittent fasting caused ameliorating effect of intermittent fasting. A potential protective effect of intermittent fasting against acrylamide can be considered according to such results. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. en_US
dc.identifier.doi 10.5505/ejm.2018.06078
dc.identifier.endpage 190 en_US
dc.identifier.issn 1301-0883
dc.identifier.issue 3 en_US
dc.identifier.scopus 2-s2.0-85051374506
dc.identifier.scopusquality Q4
dc.identifier.startpage 187 en_US
dc.identifier.trdizinid 287624
dc.identifier.uri https://doi.org/10.5505/ejm.2018.06078
dc.identifier.uri https://hdl.handle.net/20.500.14720/5186
dc.identifier.volume 23 en_US
dc.identifier.wosquality N/A
dc.institutionauthor Oğuz, E.K.
dc.language.iso en en_US
dc.publisher Yuzuncu Yil Universitesi Tip Fakultesi en_US
dc.relation.ispartof Eastern Journal of Medicine en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Acrylamide en_US
dc.subject Axon en_US
dc.subject Intermittent Fasting en_US
dc.subject Neuropathy en_US
dc.title Effect of Intermittent Fasting on Sciatic Neurofilaments in Acrylamide Administered Rats en_US
dc.type Article en_US

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