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Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(prop Derivatives

dc.authorid Aydemir, Selahattin/0000-0002-0941-2779
dc.authorid Kurt Kizildogan, Aslihan/0000-0002-9323-0993
dc.authorid Kivrak, Arif/0000-0003-4770-2686
dc.authorid Yilmaz, Can/0000-0002-0028-6614
dc.authorid Konus, Metin/0000-0002-9953-1375
dc.authorscopusid 56387553800
dc.authorscopusid 57516565000
dc.authorscopusid 57221517895
dc.authorscopusid 8694518300
dc.authorscopusid 57192910088
dc.authorscopusid 57197758391
dc.authorwosid Yilmaz, Can/Grs-2754-2022
dc.authorwosid Kivrak, Arif/Aaq-8432-2021
dc.authorwosid Arpaci, Pembegul/B-1647-2018
dc.authorwosid Aydemir, Selahattin/Acx-1253-2022
dc.authorwosid Kurt-Kizildogan, Aslihan/Jce-2182-2023
dc.authorwosid Kurt Kizildogan, Aslihan/A-1199-2019
dc.authorwosid Kivrak, Arif/W-2196-2017
dc.contributor.author Konus, Metin
dc.contributor.author Aydemir, Selahattin
dc.contributor.author Yilmaz, Can
dc.contributor.author Kivrak, Arif
dc.contributor.author Kizildogan, Aslihan Kurt
dc.contributor.author Arpaci, Pembegul Uyar
dc.date.accessioned 2025-05-10T17:43:21Z
dc.date.available 2025-05-10T17:43:21Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Konus, Metin; Aydemir, Selahattin; Yilmaz, Can] Van Yuzuncu Yil Univ, Fac Sci, Dept Mol Biol & Genet, Van, Turkey; [Kivrak, Arif] Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey; [Kizildogan, Aslihan Kurt] Ondokuz Mayis Univ, Fac Agr, Dept Agr Biotechnol, Enzyme & Microbial Biotechnol Sect, Samsun, Turkey; [Arpaci, Pembegul Uyar] Seluk Univ, Fac Sci, Dept Biotechnol, Konya, Turkey en_US
dc.description Aydemir, Selahattin/0000-0002-0941-2779; Kurt Kizildogan, Aslihan/0000-0002-9323-0993; Kivrak, Arif/0000-0003-4770-2686; Yilmaz, Can/0000-0002-0028-6614; Konus, Metin/0000-0002-9953-1375 en_US
dc.description.abstract 5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed almost the same total antioxidant capacity compared to universal trolox standard. Furthermore, Broth microdilution method and agar disc diffusion tests demonstrated that the same compound also exhibited good antibacterial activity towards the bacteria Bacillus subtilis. Finally, both of the benzaldehyde compounds showed high antifungal activity against Aspergillus niger. In this study, compound 5 (IC50: 54.3 mu g/ml) showed significant cytotoxic activity against breast adenocarcinoma cell line MCF-7 with respect to compound 3 (IC50: 173.4 mu g/ml). en_US
dc.description.sponsorship Van Yuzuncu Yil University [BAP 2015-FBE-YL364, FBA-2016-5292] en_US
dc.description.sponsorship We thank to Van Yuzuncu Yil University (BAP 2015-FBE-YL364 and FBA-2016-5292) for the generous financial support. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.2174/1570178616666181116100232
dc.identifier.endpage 423 en_US
dc.identifier.issn 1570-1786
dc.identifier.issn 1875-6255
dc.identifier.issue 5 en_US
dc.identifier.scopus 2-s2.0-85066089034
dc.identifier.scopusquality Q4
dc.identifier.startpage 415 en_US
dc.identifier.uri https://doi.org/10.2174/1570178616666181116100232
dc.identifier.uri https://hdl.handle.net/20.500.14720/15818
dc.identifier.volume 16 en_US
dc.identifier.wos WOS:000462832500005
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Bentham Science Publ Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject 2-(Prop-2-Yn-1-Yloxy)Benzaldehyde en_US
dc.subject Antioxidant en_US
dc.subject Antibacterial en_US
dc.subject Antifungal en_US
dc.subject Anticancer en_US
dc.subject Human Breast Carcinoma en_US
dc.title Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(prop Derivatives en_US
dc.type Article en_US

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