Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(prop Derivatives
dc.authorid | Aydemir, Selahattin/0000-0002-0941-2779 | |
dc.authorid | Kurt Kizildogan, Aslihan/0000-0002-9323-0993 | |
dc.authorid | Kivrak, Arif/0000-0003-4770-2686 | |
dc.authorid | Yilmaz, Can/0000-0002-0028-6614 | |
dc.authorid | Konus, Metin/0000-0002-9953-1375 | |
dc.authorscopusid | 56387553800 | |
dc.authorscopusid | 57516565000 | |
dc.authorscopusid | 57221517895 | |
dc.authorscopusid | 8694518300 | |
dc.authorscopusid | 57192910088 | |
dc.authorscopusid | 57197758391 | |
dc.authorwosid | Yilmaz, Can/Grs-2754-2022 | |
dc.authorwosid | Kivrak, Arif/Aaq-8432-2021 | |
dc.authorwosid | Arpaci, Pembegul/B-1647-2018 | |
dc.authorwosid | Aydemir, Selahattin/Acx-1253-2022 | |
dc.authorwosid | Kurt-Kizildogan, Aslihan/Jce-2182-2023 | |
dc.authorwosid | Kurt Kizildogan, Aslihan/A-1199-2019 | |
dc.authorwosid | Kivrak, Arif/W-2196-2017 | |
dc.contributor.author | Konus, Metin | |
dc.contributor.author | Aydemir, Selahattin | |
dc.contributor.author | Yilmaz, Can | |
dc.contributor.author | Kivrak, Arif | |
dc.contributor.author | Kizildogan, Aslihan Kurt | |
dc.contributor.author | Arpaci, Pembegul Uyar | |
dc.date.accessioned | 2025-05-10T17:43:21Z | |
dc.date.available | 2025-05-10T17:43:21Z | |
dc.date.issued | 2019 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Konus, Metin; Aydemir, Selahattin; Yilmaz, Can] Van Yuzuncu Yil Univ, Fac Sci, Dept Mol Biol & Genet, Van, Turkey; [Kivrak, Arif] Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey; [Kizildogan, Aslihan Kurt] Ondokuz Mayis Univ, Fac Agr, Dept Agr Biotechnol, Enzyme & Microbial Biotechnol Sect, Samsun, Turkey; [Arpaci, Pembegul Uyar] Seluk Univ, Fac Sci, Dept Biotechnol, Konya, Turkey | en_US |
dc.description | Aydemir, Selahattin/0000-0002-0941-2779; Kurt Kizildogan, Aslihan/0000-0002-9323-0993; Kivrak, Arif/0000-0003-4770-2686; Yilmaz, Can/0000-0002-0028-6614; Konus, Metin/0000-0002-9953-1375 | en_US |
dc.description.abstract | 5-bromo-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 3) and 3,5-di-tert-butyl-2-(prop-2-yn-1-yloxy)benzaldehyde (compound 5) were synthesized via nucleophilic substitution reactions. Compound 5 showed higher antioxidant capacity with respect to compound 3 in all the four different antioxidant activity methods used. Moreover, in phosphomolybdenum assay, compound 5, with 1.1 proportion value, showed almost the same total antioxidant capacity compared to universal trolox standard. Furthermore, Broth microdilution method and agar disc diffusion tests demonstrated that the same compound also exhibited good antibacterial activity towards the bacteria Bacillus subtilis. Finally, both of the benzaldehyde compounds showed high antifungal activity against Aspergillus niger. In this study, compound 5 (IC50: 54.3 mu g/ml) showed significant cytotoxic activity against breast adenocarcinoma cell line MCF-7 with respect to compound 3 (IC50: 173.4 mu g/ml). | en_US |
dc.description.sponsorship | Van Yuzuncu Yil University [BAP 2015-FBE-YL364, FBA-2016-5292] | en_US |
dc.description.sponsorship | We thank to Van Yuzuncu Yil University (BAP 2015-FBE-YL364 and FBA-2016-5292) for the generous financial support. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.2174/1570178616666181116100232 | |
dc.identifier.endpage | 423 | en_US |
dc.identifier.issn | 1570-1786 | |
dc.identifier.issn | 1875-6255 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.scopus | 2-s2.0-85066089034 | |
dc.identifier.scopusquality | Q4 | |
dc.identifier.startpage | 415 | en_US |
dc.identifier.uri | https://doi.org/10.2174/1570178616666181116100232 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/15818 | |
dc.identifier.volume | 16 | en_US |
dc.identifier.wos | WOS:000462832500005 | |
dc.identifier.wosquality | Q4 | |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 2-(Prop-2-Yn-1-Yloxy)Benzaldehyde | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Antibacterial | en_US |
dc.subject | Antifungal | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Human Breast Carcinoma | en_US |
dc.title | Synthesis and Evaluation of Antioxidant, Antimicrobial and Anticancer Properties of 2-(prop Derivatives | en_US |
dc.type | Article | en_US |