Immunohistopathological and Biochemical Study of the Effects of Dead Nettle (Urtica Dioica) Extract on Preventing Liver Lesions Induced by Experimental Aflatoxicosis in Rats
| dc.authorscopusid | 16310940800 | |
| dc.authorscopusid | 56087055000 | |
| dc.authorwosid | Yildirim, Serkan/Aah-6721-2020 | |
| dc.contributor.author | Yildirim, S. | |
| dc.contributor.author | Yener, Z. | |
| dc.date.accessioned | 2025-05-10T17:10:51Z | |
| dc.date.available | 2025-05-10T17:10:51Z | |
| dc.date.issued | 2018 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Yildirim, S.] Univ Ataturk, Fac Vet Med, Dept Pathol, Erzurum, Turkey; [Yener, Z.] Yuzuncu Yil Univ, Fac Vet Med, Dept Pathol, Van, Turkey | en_US |
| dc.description.abstract | Objective: Aflatoxicosis is a mycotoxicosis infection with an acute or chronic course that forms due to aflatoxins (AFs) in humans and animals. Aflatoxins primarily affect the liver and can lead to histopathological necrosis, fibrosis and hepatocarcinogenesis of the organ. This paper studied the preventive effects of dead nettle leaf (Urtica dioica leaf; UDL) extract on liver lesions that were induced by experimental aflatoxicosis in rats. Methods: A total of 30 rats were separated into three groups of 10 rats each. Experimental group A (control) received normal rat food, experimental group B (AFBI) received 2 mg/kg of AE and experimental group C (AFBI + UDL extract) received 2 mg/kg of AF + 2 ml/rat/day of UDL extract. After three months of experimentation, blood and tissue samples were taken from the rats by necropsy to perform chemical and histopathological analyses. Results: According to the biochemical and histopathological findings, antioxidant system activity increased and lipid peroxidation and liver enzyme levels decreased in the group that received UDL extract. Conclusion: The extract of UDL had hepatoprotective effects against aflatoxicosis. | en_US |
| dc.description.sponsorship | Turkish Scientific and Technological Research Council of Turkey [104 V 139] | en_US |
| dc.description.sponsorship | This study was summarized from the PhD thesis of the same title. This project was supported by Turkish Scientific and Technological Research Council of Turkey (project number: 104 V 139). | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.7727/wimj.2016.126 | |
| dc.identifier.endpage | 261 | en_US |
| dc.identifier.issn | 0043-3144 | |
| dc.identifier.issn | 2309-5830 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.scopus | 2-s2.0-85040986770 | |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 254 | en_US |
| dc.identifier.uri | https://doi.org/10.7727/wimj.2016.126 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/7561 | |
| dc.identifier.volume | 67 | en_US |
| dc.identifier.wos | WOS:000452531100012 | |
| dc.identifier.wosquality | Q4 | |
| dc.language.iso | en | en_US |
| dc.publisher | Univ West indies Faculty Medical Sciences | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Aflatoxicosis | en_US |
| dc.subject | Extract Of Dead Nettle Leaf | en_US |
| dc.subject | Liver Lesions | en_US |
| dc.subject | Rat | en_US |
| dc.title | Immunohistopathological and Biochemical Study of the Effects of Dead Nettle (Urtica Dioica) Extract on Preventing Liver Lesions Induced by Experimental Aflatoxicosis in Rats | en_US |
| dc.type | Article | en_US |