One-Pot Synthesis of 4-(phenylselanyl) Pyrazoles
| dc.authorid | Kivrak, Arif/0000-0003-4770-2686 | |
| dc.authorid | Zora, Metin/0000-0001-7764-2288 | |
| dc.authorscopusid | 6603747040 | |
| dc.authorscopusid | 57225832309 | |
| dc.authorscopusid | 8694518300 | |
| dc.authorscopusid | 56105099500 | |
| dc.authorwosid | Zora, Metin/Abb-7678-2020 | |
| dc.authorwosid | Kivrak, Arif/W-2196-2017 | |
| dc.contributor.author | Zora, Metin | |
| dc.contributor.author | Demirci, Deniz | |
| dc.contributor.author | Kivrak, Arif | |
| dc.contributor.author | Kelgokmen, Yilmaz | |
| dc.date.accessioned | 2025-05-10T17:39:36Z | |
| dc.date.available | 2025-05-10T17:39:36Z | |
| dc.date.issued | 2016 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Zora, Metin; Demirci, Deniz; Kivrak, Arif; Kelgokmen, Yilmaz] Middle E Tech Univ, Dept Chem, TR-06800 Ankara, Turkey; [Kivrak, Arif] Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey | en_US |
| dc.description | Kivrak, Arif/0000-0003-4770-2686; Zora, Metin/0000-0001-7764-2288 | en_US |
| dc.description.abstract | A facile, one-pot, general synthetic method for the preparation of 4-(phenylselanyl)pyrazoles is described. When reacted with hydrazines, alpha,beta-alkynic aldehydes produced in situ alpha,beta-alkynic hydrazones, which, upon treatment with phenylselenyl chloride, undergo cyclization to afford 4-(phenylselanyl)pyrazoles in good to high yields. This cyclization has been found to be general for a variety of in situ generated alpha,beta-alkynic hydrazones and exhibits good tolerance to a broad range of substituents, including electron-donating and electron-withdrawing groups. The enrichment of the pyrazole core with a selenyl moiety as well as with aryl and/or ferrocenyl groups may offer potential for the synthesis of molecules with pronounced or distinct biological activities. (C) 2016 Elsevier Ltd. All rights reserved. | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) [110T113]; Research Fund of Middle East Technical University (Orta Dogu Teknik Universitesi) [BAP-2011-07-02-00-01] | en_US |
| dc.description.sponsorship | We thank the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No. 110T113) and the Research Fund of Middle East Technical University (Orta Dogu Teknik Universitesi, Grant No. BAP-2011-07-02-00-01) for financial support of this research. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded - Index Chemicus - Current Chemical Reactions | |
| dc.identifier.doi | 10.1016/j.tetlet.2016.01.071 | |
| dc.identifier.endpage | 997 | en_US |
| dc.identifier.issn | 0040-4039 | |
| dc.identifier.issue | 9 | en_US |
| dc.identifier.scopus | 2-s2.0-84957427854 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 993 | en_US |
| dc.identifier.uri | https://doi.org/10.1016/j.tetlet.2016.01.071 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/14933 | |
| dc.identifier.volume | 57 | en_US |
| dc.identifier.wos | WOS:000373408800007 | |
| dc.identifier.wosquality | Q3 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pergamon-elsevier Science Ltd | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Pyrazole | en_US |
| dc.subject | Selenium | en_US |
| dc.subject | Cyclization | en_US |
| dc.subject | Ferrocene | en_US |
| dc.subject | Hydrazine | en_US |
| dc.subject | Propargyl Aldehyde | en_US |
| dc.title | One-Pot Synthesis of 4-(phenylselanyl) Pyrazoles | en_US |
| dc.type | Article | en_US |