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Selection of the Polymers Used in Oral Dispersible Films Via Analytical Hierarchy Process

dc.authorid Arslan, Miray/0000-0003-2786-4610
dc.authorscopusid 57212671825
dc.authorscopusid 56675405800
dc.authorwosid Arslan, Miray/Afr-2464-2022
dc.authorwosid Akbal-Dagistan, Ozlem/Q-1443-2019
dc.contributor.author Dagistan, Ozlem Akbal
dc.contributor.author Arslan, Miray
dc.date.accessioned 2025-05-10T17:34:38Z
dc.date.available 2025-05-10T17:34:38Z
dc.date.issued 2024
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Dagistan, Ozlem Akbal] Istanbul Univ, Fac Pharm, Dept Pharmaceut Technol, TR-34116 Istanbul, Turkiye; [Arslan, Miray] Van Yuzuncu Yil Univ, Fac Pharm, Dept Pharm Management, TR-65080 Van, Turkiye en_US
dc.description Arslan, Miray/0000-0003-2786-4610 en_US
dc.description.abstract Many different active ingredients and excipients are used in the production of pharmaceutical products. Selection of the most suitable active ingredients and excipients is one of the most important stages of pharmaceutical production. When choosing the active ingredients and excipients, several factors and alternatives should be considered. In this instance, it is thought that one of the multi-criteria decision-making techniques, an operational research model, the Analytical Hierarchy Process, can assist in identifying the excipients during the pre-formulation stage. Using the Analytical Hierarchy Process, the current study seeks to identify the polymers most suitable for producing oral dispersible film formulations. The problem's criteria and potential solutions were determined before establishing the goal. Then, pairwise comparison matrices were generated, and the generated matrices were sent to the Super Decisions Version 3.2 software to reach a solution/result. The study's findings showed that the forming capacity is the most crucial factor affecting the choice of polymer to be used in the pre-formulation of oral dispersible films. Hydroxypropyl methylcellulose (14.89%) was found to be the best alternative among the polymers, followed by hydroxyethyl cellulose (12.04%) and carboxymethyl cellulose (11.58%). It was revealed that the least preferred polymers were sodium alginate (5.6%) and pectin (6.8%), which are natural polymers. It is clear from the outcomes of the various pre-formulation investigations that polymer selection in oral dispersible film formulations is one of the most critical points. This study provides a new approach to selecting the most appropriate polymers in oral dispersible film formulations. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.doi 10.29228/jrp.812
dc.identifier.endpage 1343 en_US
dc.identifier.issn 2630-6344
dc.identifier.issue 4 en_US
dc.identifier.scopus 2-s2.0-85201827638
dc.identifier.scopusquality Q4
dc.identifier.startpage 1331 en_US
dc.identifier.uri https://doi.org/10.29228/jrp.812
dc.identifier.uri https://hdl.handle.net/20.500.14720/13871
dc.identifier.volume 28 en_US
dc.identifier.wos WOS:001288934400038
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Marmara Univ en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Analytical Hierarchy Process en_US
dc.subject Pharmaceutical Production en_US
dc.subject Excipient Selection en_US
dc.subject Pre-Formulation en_US
dc.subject Oral Dispersible Films en_US
dc.title Selection of the Polymers Used in Oral Dispersible Films Via Analytical Hierarchy Process en_US
dc.type Article en_US

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