Investigation of Radiological Properties of Imaging Agents Used in Nu Clear Med I Cine With Dif Fer Ent Meth Ods and Gate/Geant4 Sim U La Tion Pro Gram

Abstract

This study aims to determine the radiological properties of various radiopharmaceuticals used in nuclear medicine. In the study, mass attenuation coefficient values in different energy ranges were ob tained for six dif fer ent radiopharmaceuticals dimercaptosuccinic acid, diethylenetriamine pentaacetate, mercaptoacetyltriglycine, hexamethylpropyleneamine oxime, methoxyisobutylisonitrile, meth y lene diphosphate by us ing GATE sim u la tion pro gram, XCOM and WinXCom pro grams. Us ing these val ues, ef fec tive atomic num ber and elec tron den sity val ues were cal cu lated with the help of the di rect method, in ter po la tion method, Auto-Zeff soft ware, Phy-X/ZeXTra, XMuDat pro gram, and Mayneourd's for mula. In ad di tion, the ef fec tive atomic num ber and elec tron den sity val ues ob tained were com pared for each radiopharmaceutical, both among them selves and be tween the meth ods. When radiopharmaceuticals were com pared among them selves in low and high-en ergy re gions, the high est ef fec tive atomic num ber val ues were ob tained in dimercaptosuccinic acid, meth y lene diphosphate, and mercaptoacetyltriglycine. The mass attenuation coefficient values calculated us ing the GATE code in di cate that it is a suit able method for de ter min ing the mass at tenuation coefficient for imaging agents with no experimental values. This study indicates that the sim u la tion ge om e try method is suit able to be used as an al ter na tive method for the ex per i ments. In ad di tion, the val ues ob tained for these mol e cules used as radiopharmaceuticals were ex am ined for the first time.