Development of an Ultra-Sensitive Method Using Nafion and Multi-Walled Carbon Nanotube Coated Glassy Carbon Electrode for Atenolol Determination

Abstract

Atenolol (Scheme 1) is antihypertensive drug that form beta-blocker group, which widely used in the treatment of hypertension In this study, the redox properties of the Tensinor drug used in blood pressure treatment were examined on modified glassy carbon electrode and the electrodes prepared by coating carbon nanotubes on this modified electrode. In order to investigate the effects of nafion coated multi-walled glass nanotube (MWCNT /NGCE) electrode response and nafion coated glassy carbon electrode (NGCE) and electrode responses of only glassy carbon electrode (GCE) surfaces on the support electrolyte, pH and scan rate, the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used. Atenolol (ATN) was observed in the BrittonRobinson (BR) buffer solution (pH 7.0) thereabouts 1.11 V (vsAg / AgCl (3.0 mol L-1 KCl). Voltammetric method reacted linear at a concentration range between 3x10-5 mu M and 9x10-2 mu M under optimum analytical experimental conditions. The results of Tensinor's limit of detection on the Britton-Robinson (BR) (pH= 7) buffer were found to be 7.67 x 10-5 mM and 2.5 x 10-4 mM, respectively. Additionally, in the study, interference effects experiments were performed with auxiliary substances used in the preparation of medicines and no negative effect was observed.