Do Hba1c, Ldl and Hdl Levels Determine the Level of Amputation

Abstract

Introduction: Diabetes mellitus (DM) is the most common endocrine disorder worldwide; its frequency is increasing and has already reached epidemic proportions. Foot ulcers and amputation are the chief complications of DM and the most significant causes of morbidity and mortality in diabetic patients .The aim of this study was to investigate the relationships between the level of amputation and serum HbA1c, cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in patients who underwent amputation at any level in the lower extremities due to diabetic foot. Materials and methods: Patients who underwent lower extremity amputation due to diabetic foot between 2014 and 2017 were included in the study. Patients were divided into three groups according to the level of amputation: group 1, amputation of the Pot and toes; group 2, amputation at the knee and transtibial amputation; and group 3, femoral amputation and hip joint disarticulation. Results: The average HbA1c level (11.899%) was significantly higher in group 3 than in groups 1 and 2 (p<0.01; The mean HDL value was significantly higher in group 1 (33 483 mg/dL) than in groups 2 (26396 mg/dL) and 3 (17.7(X) mg/dL; p<0.01). Conclusion: In patients undergoing diabetic foot treatment, we believe that high HDL levels and low HbA1c levels will help to decrease the lower extremity amputation level. Finally, we believe that HbA1c and HDL should be included in any new scale for diabetic foot amputation risk classification.