Investigation of a Counteragent for Monensin Toxicity
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Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific and Technical Research Council of Turkey
Abstract
This experiment was carried out in Veterinary Medicine at Iowa State University, USA. The ability of ryanodine to counteract the toxic effect of monensin was investigated by using adult male guinea-pigs. Heart rate and mean arterial blood pressure were measured. Data were collected every five minutes for one hour after drug injection then averaged. The toxic dose of monensin significantly (P<0.05) decreased the heart rate and mean arterial blood pressure of guinea-pigs. However, decreased heart rate and mean arterial blood pressure caused by monensin were significantly (P<0.05) increased by ryanodine. It is concluded that ryanodine has a potent to be used as a counteragent for monensin poisoning.
Description
Keywords
Calcium, Guinea-Pig, Heart, Monensin, Ryanodine
Turkish CoHE Thesis Center URL
WoS Q
Q4
Scopus Q
Q3
Source
Turkish Journal of Veterinary and Animal Sciences
Volume
21
Issue
4
Start Page
355
End Page
358