On Topological Indices of Remdesivir Compound Used in Treatment of Corona Virus (Covid 19)
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Abstract
Corona virus cause diseases ranging from the common cold to Severe Acute Respiratory Syndrome (SARS). Several therapeutic agents have been evaluated for the treatment of Covid-19, but none have yet been shown to be efficacious. Remdesivir Gilead Sciences number (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase with inhibitory activity against SARS-CoV and the Middle East respiratory syndrome (MERS-CoV), was identified early as a promising therapeutic candidate for Covid-19 because of its ability to inhibit SARS-CoV-2 invitro. Knowledge about the potential efficacy of Remdesivir against corona viruses has been restricted to in vitro studies and animal models. However, information related to COVID-19 is rapidly growing. Several clinical trials are ongoing for the management of COVID-19 using Remdesivir. Efficacy of Remdesivir (GS-5734) against Ebola virus has been demonstrated. In the field of Medical Science, concerning the definition of the topological index on the molecular structure and corresponding medical, biological, chemical, pharmaceutical properties of drugs can be studied by the topological index calculation. In this paper, we compute some reverse topological indices namely, the reverse general Randic index, the reverse atom bond connectivity index, the reverse geometric arithmetic index, the reverse forgotten index, the reverse Balaban index and the reverse Zagreb type indices.
Description
Hanif, Muhammad Farhan/0000-0002-2439-3967; Wei, Jianxin/0000-0003-0165-7031; Siddiqui, Muhammad Kamran/0000-0002-2607-4847
Keywords
Reverse Degree, Reverse Randic Index, Reverse Atom Bond Connectivity Index, Reverse Hyper Zagreb Index, Remdesivir, Corona Virus
Turkish CoHE Thesis Center URL
WoS Q
Q2
Scopus Q
Q3
Source
Volume
42
Issue
7
Start Page
4300
End Page
4316