The Effect of Evening Primrose (Oenothera Biennis) on the Some Biochemical Parameters in Rats With Gentamicin Induced Nephrotoxicity
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Date
2021
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Abstract
In this study, it was aimed to investigate the effect of evening primrose oil (EPO) on somebiochemical parameters on nephrotoxicity induced by gentamicin (GM) in rats. The rats used in thestudy were randomly divided into 4 groups each consisting of 8 rats. The control group, EPO group,GM group and GM+ EPO group. The blood samples were taken 24 hours after the 8-day trial andkidneys were removed and saved for histopathological and PGE2 analysis. The serum creatinine,BUN, calcitriol, Ca, Na, Cl, K and P analyzes were performed via autoanalyser. PGE2 analysis wasperformed in kidney tissue via ELISA. Histopathological examination of the kidney tissues wasperformed. The levels of creatinine, BUN and Cl were significantly decreased and PGE2 and Caincreased in GM + EPO compared to GM group. The changes in the biochemical parametersexamined and the histopathological findings obtained, it can be said that the EPO weakens thenephrotoxic damage caused by GM and has the protective effects on the kidney.
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Keywords
Tamamlayıcı Ve Entegre Tıp, Endokrinoloji Ve Metabolizma, Üroloji Ve Nefroloji, Veterinerlik
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N/A
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N/A
Source
Türk Tarım - Gıda Bilim ve Teknoloji dergisi
Volume
9
Issue
6
Start Page
1008
End Page
1014