Effect of Heroin on Right Ventricular Cardiac Performance

Abstract

Objective: The aim of this study was to investigate the effects of heroin addiction. which is an important social and health problem, on right cardiac function. Methods: A total of 85 individuals were included in the study The study group comprised 45 patients smoking heroin and the control group was 40 healthy individuals with no drug addiction. Patients injecting heroin were excluded. Echocardiographic evaluation of patients using heroin was performed and compared with those in the control group. Results: The right ventricle and pulmonary artery diameters in the heroin group were found to be higher compared to the control group. The myocardial performance index (WI) was higher and more abnormal in the heroin group (0.48 +/- 0.22 vs 0.39 +/- 0.11, p < 0.05) whereas isovolumic acceleration d VA) of the right ventricle was significantly lower in the heroin group (2.92 +/- 0.69 vs 3.4 +/- 0.68 m/s(2), p < 0.01). No significant difference was observed between the groups with regard to the right ventricular ejection fraction (RVEF) (59.6 +/- 2.5 vs 60.6 +/- p = 0.08), tricuspid annular plain systolic excursion (TAPSE) (24.1 +/- 4.2 vs 24.5 +/- 2.4 mm,p = 0.7), tissue Doppler imaging S wave (TDI-S) (13.7 +/- 2.1 vs 13.8 +/- 2.1 cm/s, p = 0.86) and right ventricular fractional area change (RVFAC) (42.7 +/- 8.3 vs 43.9 +/- 3.5%, p = 0.4). Multivariate and univariate regression analyses revealed independent correlation between the pulmonary artery diameter and RVIVA, and heroin addiction. Conclusion: Heroin addiction negatively affected right ventricular function and more attention should be paid to the cardiac function of these patients.