Chemoenzymatic Synthesis of a 1,2,3-Triazolo Derivative
| dc.authorid | Gumus, Aysegul/0000-0002-1613-7074 | |
| dc.authorscopusid | 6603208702 | |
| dc.authorscopusid | 56437653800 | |
| dc.contributor.author | Gumus, Aysegul | |
| dc.contributor.author | Mert, Kudret | |
| dc.date.accessioned | 2025-05-10T17:43:45Z | |
| dc.date.available | 2025-05-10T17:43:45Z | |
| dc.date.issued | 2015 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Gumus, Aysegul; Mert, Kudret] Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey | en_US |
| dc.description | Gumus, Aysegul/0000-0002-1613-7074 | en_US |
| dc.description.abstract | The stereoselective synthesis of a 1,2,3-triazolod-lactone (+)-6 derived from a homoallyl alcohol (S)-(-)-1 backbone was accomplished. 2-Thienyl-substituted allyl alcohol rac-1 was efficiently resolved through enzymatic method with high ee (95%) and known stereochemistry. An enantiomerically enriched azidoalcohol (+)-4 derived from a homoallyl alcohol was subjected to the Huisgen 1,3-dipolar cycloaddition reaction with diethyl acetylenedicarboxylate, followed by intramolecular cyclization of the corresponding cycloadduct (+)-5, to yield the 1,2,3-triazolo-delta-lactone derivative. | en_US |
| dc.description.sponsorship | Yuzuncu Yil University, Scientific Research Projects Department (BAP) [2013-FEN-B013] | en_US |
| dc.description.sponsorship | We are grateful to the Yuzuncu Yil University, Scientific Research Projects Department (BAP No. 2013-FEN-B013). | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1515/hc-2014-0155 | |
| dc.identifier.endpage | 46 | en_US |
| dc.identifier.issn | 0793-0283 | |
| dc.identifier.issn | 2191-0197 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopus | 2-s2.0-84922495853 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 43 | en_US |
| dc.identifier.uri | https://doi.org/10.1515/hc-2014-0155 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/15966 | |
| dc.identifier.volume | 21 | en_US |
| dc.identifier.wos | WOS:000349471400008 | |
| dc.identifier.wosquality | Q2 | |
| dc.language.iso | en | en_US |
| dc.publisher | Walter de Gruyter Gmbh | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Azide-Alkyne Cycloaddition | en_US |
| dc.subject | Enzymatic Resolution | en_US |
| dc.subject | 2-Azidoalcohol | en_US |
| dc.subject | 1,2,3-Triazolo-Delta-Lactone | en_US |
| dc.title | Chemoenzymatic Synthesis of a 1,2,3-Triazolo Derivative | en_US |
| dc.type | Article | en_US |