Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella Bursa-Pastoris L.) on Ethanol-Induced Liver Damage
| dc.authorscopusid | 58781602500 | |
| dc.authorscopusid | 18539360300 | |
| dc.authorscopusid | 57203863080 | |
| dc.contributor.author | Polat, Orhan | |
| dc.contributor.author | Yaman, Turan | |
| dc.contributor.author | Koemueroglu, Ahmet Ufuk | |
| dc.date.accessioned | 2025-05-10T17:42:06Z | |
| dc.date.available | 2025-05-10T17:42:06Z | |
| dc.date.issued | 2024 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Polat, Orhan] Gaziantep Islam Bilim Teknol Univ, Vocat Sch Hlth Serv, Gaziantep, Turkiye; [Yaman, Turan] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Pathol, Van, Turkiye; [Koemueroglu, Ahmet Ufuk] Van Yuzuncu Yil Univ, Vocat Sch Hlth Serv, Van, Turkiye; [Yaman, Turan] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Pathol, TR-65040 Van, Turkiye | en_US |
| dc.description.abstract | Background: The aim of the present study was to investigate the hepatoprotective effect of Shepherd's Purse (SP) herbal tea on ethanol (EtOH)-induced liver toxicity. Materials and Methods: Male Wistar rats (n = 32) were divided into 4 experimental groups: control, EtOH administered by orogastric gavage once daily. At the end of the 60-day experimental period, tissue and blood samples were obtained from the rats following necropsy. Results: Histopathologically, degenerative-necrotic changes in the liver of the EtOH group rats were partially reduced in the SP treatment group. Biochemical examinations revealed that SP treatment decreased aspartic transaminase, alanine transaminase, and alkaline phosphatase levels in the SP-treated rats compared to the EtOH group rats. While SP treatment had a positive effect on the triglyceride and HDL levels, it had a negative effect on the LDL and cholesterol levels. Conclusion: Consequently, it was determined that SP tea provides partial protection against EtOH-induced liver toxicity. | en_US |
| dc.description.sponsorship | Van Yuzuncu Yil University Scientific Research Projects Foundation [TYL-2018-6759] | en_US |
| dc.description.sponsorship | This study was funded by the Van Yuzuncu Yil University Scientific Research Projects Foundation (Grant number TYL-2018-6759) . This study was prepared from Orhan POLAT's Master's thesis. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.5530/ijper.58.1.21 | |
| dc.identifier.endpage | 203 | en_US |
| dc.identifier.issn | 0019-5464 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopus | 2-s2.0-85180675394 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 198 | en_US |
| dc.identifier.uri | https://doi.org/10.5530/ijper.58.1.21 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/15465 | |
| dc.identifier.volume | 58 | en_US |
| dc.identifier.wos | WOS:001178211900026 | |
| dc.identifier.wosquality | Q4 | |
| dc.language.iso | en | en_US |
| dc.publisher | Assoc Pharmaceutical Teachers india | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Shepherd'S Purse | en_US |
| dc.subject | Ethanol | en_US |
| dc.subject | Histopathology | en_US |
| dc.subject | Liver | en_US |
| dc.subject | Rat. | en_US |
| dc.title | Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella Bursa-Pastoris L.) on Ethanol-Induced Liver Damage | en_US |
| dc.type | Article | en_US |