A Biochemical Study on the Protective Potential of Centaurium Erythraea L. in Rats at Acute Aspirin Exposure

Abstract

The aim of this study was to determine protective effect of Centaurium erythraea L. on rats exposed to aspirin (ASA). The protective influence of the 50% aqueous-ethanolic Centaurium erythraea L. extract (AECE) (100 mg/kg body weight) was investigated in rats exposed to a single dose of 200 mg/kg body weight ASA administration. Twenty-one Sprague-Dawley albino rats were distributed into three groups equally (n=7) as follows: A (control), B (only ASA-treated) and C (ASA+AECE-treated) group. At the end of 4 h ASA administration to groups B and C, some serum biochemical constituents were assigned and compared between the groups. Results showed that levels of aspartate aminotransferase, alanine aminotransferase, creatinine and potassium increased in group B compared with the control group, but they were decreased significantly with AECE supplementation. While lipase activity decreased only in group B, level of uric acid decreased both in groups B and C compared with control group. In conclusion, the current trial has shown that treatment of AECE with ASA supplied relative protection against acute ASA toxicity through ameliorating some blood parameters.