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Synthesis, Antioxidant, Dna Cleavage and Antimicrobial Properties of Phthalocyanine Complexes Bearing the Poly-Hydroxyl Groups

dc.authorid Agirtas, Mehmet Salih/0000-0003-1296-2066
dc.authorscopusid 55663235100
dc.authorscopusid 55366792300
dc.authorscopusid 14036733200
dc.authorscopusid 29867470700
dc.authorscopusid 57196191053
dc.contributor.author Agirtas, Mehmet Salih
dc.contributor.author Cabir, Beyza
dc.contributor.author Yildiko, Umit
dc.contributor.author Ozdemir, Sadin
dc.contributor.author Gonca, Serpil
dc.date.accessioned 2025-05-10T17:07:40Z
dc.date.available 2025-05-10T17:07:40Z
dc.date.issued 2021
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Agirtas, Mehmet Salih; Cabir, Beyza] Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, TR-65080 Van, Turkey; [Yildiko, Umit] Kafkas Univ, Architecture & Engn Fac, Dept Bioengn, Kars, Turkey; [Ozdemir, Sadin] Mersin Univ, Tech Sci Vocat Sch, Food Proc Programme, TR-33343 Yenisehir, Mersin, Turkey; [Gonca, Serpil] Mersin Univ, Hlth Serv Vocat Sch, Dept Med Lab Serv, TR-33343 Yenisehir, Mersin, Turkey en_US
dc.description Agirtas, Mehmet Salih/0000-0003-1296-2066 en_US
dc.description.abstract (4-((1-((2-(bis(2-hydroxypropyl) amino) ethyl) (2-hydroxypropyl) amino) propan-2-yl) oxy) phthalonitrile) (BHHP) was synthesized from reaction N, N, N ', N '- tetrakis (2-hydroxypropyl) ethylene diamine (SM) with 4-nitro phthalonitrile. Zinc, cobalt and copper phthalocyanine complexes were achieved from the reaction of BHHP compound with metal salts. Quantum chemical studies of these phthalocyanines have been computationally supported using density functional theory methods. The antioxidant properties of phthalocyanine compounds were determined with the help of l, l-diphenyl-2-picrilhydrazyl radical scavenging ability and chelating ability to iron ions. Compound 6 showed 72.8% inhibition of DPPH free radicals at 200 mg/L concentration and compound 4 showed 71.5% ferrous metal chelating activity at 200 mg/L concentration. The antimicrobial and DNA cleavage activities of compounds were also investigated. All tested phthalocyanine compounds showed excellent nuclease activity at all concentration. Antimicrobial activities of phthalocyanine compounds were detected using broth microdilution method and all test compounds demonstrated perfect antimicrobial activities. According to in vitro studies, copper phthalocyanine compound 6 has the best activity against the P. aeruginosa with 8 mu g/mL of MIC value. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1007/s11696-020-01432-7
dc.identifier.endpage 1760 en_US
dc.identifier.issn 0366-6352
dc.identifier.issn 2585-7290
dc.identifier.issue 4 en_US
dc.identifier.scopus 2-s2.0-85096618763
dc.identifier.scopusquality Q3
dc.identifier.startpage 1749 en_US
dc.identifier.uri https://doi.org/10.1007/s11696-020-01432-7
dc.identifier.uri https://hdl.handle.net/20.500.14720/6834
dc.identifier.volume 75 en_US
dc.identifier.wos WOS:000592150300001
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Springer int Publ Ag en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Phthalocyanines en_US
dc.subject Synthesis en_US
dc.subject Antioxidant en_US
dc.subject Dna Cleavage en_US
dc.subject Antimicrobial en_US
dc.title Synthesis, Antioxidant, Dna Cleavage and Antimicrobial Properties of Phthalocyanine Complexes Bearing the Poly-Hydroxyl Groups en_US
dc.type Article en_US

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