The Effect of Moclobemide, Reversible Inhibitor of Monoamine Oxidase-A, on the Alcoholized Rat Brain
| dc.authorid | Karaoz, Erdal/0000-0002-9992-833X | |
| dc.authorscopusid | 7003448087 | |
| dc.authorscopusid | 7006356462 | |
| dc.authorscopusid | 6504719523 | |
| dc.authorwosid | Karaoz, Erdal/Aao-1470-2020 | |
| dc.contributor.author | Karaöz, E | |
| dc.contributor.author | Kanter, M | |
| dc.contributor.author | Bapçi, Z | |
| dc.date.accessioned | 2025-05-10T16:59:12Z | |
| dc.date.available | 2025-05-10T16:59:12Z | |
| dc.date.issued | 2002 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | Suleyman Demirel Univ, Dept Histol & Embryol, Fac Med, Isparta, Turkey; Gulhane Mil Med Acad, Dept Pharmacol, Ankara, Turkey; Yuzuncu Yil Univ, Fac Vet Med, Dept Histol & Embryol, TR-65080 Kampus, Van, Turkey | en_US |
| dc.description | Karaoz, Erdal/0000-0002-9992-833X | en_US |
| dc.description.abstract | This experiment was carried out to demonstrate the effect of moclobemide on the brains of rats fed on a diet containing alcohol. Thirty male rats, 200250 g were used. Rats were fed with a diet (milk) containing ethyl alcohol (10%) in the alcohol-only treated group and were injected subcutaneously with moclobemide (30 mg/kg) in the alcohol+moclobemide treated group daily for 21 days. It is found that the serum ethanol level in the alcohol+moclobemide treated group was significantly higher than in alcohol-only treated group at the end of the experiment. Electron microscopic examination revealed more prominent neurotoxicity in the alcohol+moclobemide treated group than in alcohol-only treated group. We concluded that moclobemide decreases the elimination of ethanol. However, more studies are needed to demonstrate its mechanism. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.endpage | 225 | en_US |
| dc.identifier.issn | 0901-3393 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopus | 2-s2.0-0036984001 | |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 217 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/4521 | |
| dc.identifier.volume | 29 | en_US |
| dc.identifier.wos | WOS:000180722200003 | |
| dc.identifier.wosquality | Q3 | |
| dc.language.iso | en | en_US |
| dc.publisher | Scandinavian Federation Laboratory Animal Science | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | The Effect of Moclobemide, Reversible Inhibitor of Monoamine Oxidase-A, on the Alcoholized Rat Brain | en_US |
| dc.type | Article | en_US |