Antinociceptive and Anti-Inflammatory Activities of Viburnum Opulus
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Abstract
Water extract of Viburnum opulus L. (Caprifoliaceae) (VO) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VO causes dose related inhibition in acetic acid-induced abdominal stretching in mice. VO inhibited abdominal stretching at 100 and 200 mg/kg. VO showed antinociceptive activity, which was quantified by the tail-flick test at doses of 100 and 200 mg/kg. However, VO did not have an anti-inflammatory effect at these doses. The LD50 of VO was determined as 5.447 g/kg.
Description
Saltan, Hayriye Gulcin/0000-0001-6633-0713; Sever Yilmaz, Betul/0000-0003-2084-9514
Keywords
Anti-Inflammatory Activity, Antinociceptive Activity, Median Lethal Dose (Ld50), Viburnum Opulus
Turkish CoHE Thesis Center URL
WoS Q
Q1
Scopus Q
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Source
Volume
47
Issue
7
Start Page
653
End Page
658