The Effects of Some Fungicides on Activity of Eight Serum Enzymes in Vitro

Abstract

The purpose of the present study was to investigate the effects of Benlate [1-(N-butyl carbomyl), 2-(metoxy carboxyamido)-benzimidazol], Penncozep [mangan-zinc ethylenediamine- bisdithicarbamate], Bayleton [1-(4- chlorophenoxy)- 3,3 -dimethyl-1(1-H-1,2,4 - thiazol -1- yl)- 2.2 - butanon], Cupravit [Cuper oxichloride] and Dithane [Manganese etylenebidithiocarbamate] on human serum enzymes, myocardial creatine kinase (CK-MB), amylase, creatine kinase (CK), aspartate amino transferase (AST), serum glutamyl pruvic transferase(SGPT), alkaline phosphatase (ALK-P), delta glutamyl transferase (GGT-P) and lactate dehydrogenase (LDH), in vitro. Bayleton inhibited only SGPT and it was ineffective on the other seven enzymes. Benlate, Penncozep, Cupravit and Dithane inhibited some enzymes, but activated the others. Benlate as the strongest inhibitor for CK-MB, Cupravit for Amylase, Dithane for ALK-P, Penncozep for CK, AST, SOFT and GGT-P. No inhibition was occurred in LDH. Of the fungicides studied the maximum effective one was Penncozep, the minimum effective one was Bayleton. The most inhibition was shown in SGPT and CK. Cupravit was found as an activator rather than an inhibitor.