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Gundelia Rosea Seed: Evaluation of Biopharmaceutical Potential and Bioactive Composition

dc.authorid Mukemre, Muzaffer/0000-0001-6154-6603
dc.authorid Zengin, Gokhan/0000-0001-6548-7823
dc.authorid Dalar, Abdullah/0000-0002-0080-2519
dc.authorid Bengu, Aydin Sukru/0000-0002-7635-4855
dc.authorscopusid 55208137400
dc.authorscopusid 8411629800
dc.authorscopusid 55624671000
dc.authorscopusid 56344356500
dc.authorscopusid 57097277000
dc.authorwosid Bengu, Aydin/Gpp-4213-2022
dc.authorwosid Dalar, Abdullah/K-9238-2013
dc.authorwosid Mukemre, Muzaffer/Aad-2456-2020
dc.authorwosid Zengin, Gokhan/Gls-8806-2022
dc.authorwosid Zengin, Gokhan/K-9393-2015
dc.contributor.author Dalar, A.
dc.contributor.author Zengin, G.
dc.contributor.author Mukemre, M.
dc.contributor.author Bengu, A. S.
dc.contributor.author Isler, S.
dc.date.accessioned 2025-05-10T17:25:59Z
dc.date.available 2025-05-10T17:25:59Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Dalar, A.] Van Yuzuncu Yil Univ, Dept Pharmaceut Bot, Fac Pharm, Campus Zeve, TR-65090 Van, Turkey; [Zengin, G.] Selcuk Univ, Dept Biol, Fac Sci, Konya, Turkey; [Mukemre, M.] Van Yuzuncu Yil Univ, Dept Biol, Fac Sci, Van, Turkey; [Bengu, A. S.] Univ Bingol, Dept Med Serv & Tech, Vocat Sch Hlth Serv, Bingol, Turkey; [Isler, S.] Van Yuzuncu Yil Univ, Dept Sci & Math, Fac Educ, Van, Turkey en_US
dc.description Mukemre, Muzaffer/0000-0001-6154-6603; Zengin, Gokhan/0000-0001-6548-7823; Dalar, Abdullah/0000-0002-0080-2519; Bengu, Aydin Sukru/0000-0002-7635-4855 en_US
dc.description.abstract Gundelia species are among significant key medicinal plants extensively utilized in folk medicine of Middle Eastern countries. This study focused on researching the biopharmaceutical potency and bioactive compounds of Gundelia rosea seed. Hereby, traditional knowledge-based preparing methods (infusion and decoction) and ethanol-based lyophilized extracts obtained from Gundelia rosea seeds were assessed for (i) antioxidant capacities, (ii) enzyme inhibitory activities, (iii) HPLC-MS/MS and (iv) GC-MS studies. Phytochemical analysis revealed that ethanol extract which primarily compromised of mainly phenolics (4-Caffeoylquinic acid and luteolin hexoside) and several fatty acids (palmitic, stearic, oleic and linoleic acids), was superior to those of infusion and decoction extracts. Antioxidant activities findings revealed that ethanol extract contained a high level of total phenolics (55.3 mg Gallic acid Eq./g extract) and had high capacities of reducing (1683 mu mol Fe2+ and 214.1 mg Trolox Eq./g extract for FRAP and CUPRAC respectively) and radical scavenging (ORAC: 2241.9 mu mol, DPPH: 91.7 mg, ABTS: 141.2 mg Trolox Eq./g extract) and total antioxidant (Phosphomolybdenum: 1.39 mmol Trolox Eq./g extract) properties. The suppressive abilities of the extracts against selected isolated enzymes revealed that ethanol extract had pronounced levels of inhibitory activities against AChE (4.3 mg Galanthamine Eq.), BChE (3.4 mg Galanthamine Eq.), tyrosinase (120 mg Kojic acid Eq.), amylase (0.61 mmol Acarbose Eq.), glucosidase (11.91 mmol Acarbose Eq.) and lipase (53.4 mu mol Orlistat Eq.) per gram extract. Findings obtained within this study confirmed the traditional utilization of Gundelia rosea and suggest its potential as a novel candidate of biopharmaceutical agents for public health problems. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.sajb.2019.08.024
dc.identifier.endpage 510 en_US
dc.identifier.issn 0254-6299
dc.identifier.issn 1727-9321
dc.identifier.scopus 2-s2.0-85071399471
dc.identifier.scopusquality Q1
dc.identifier.startpage 505 en_US
dc.identifier.uri https://doi.org/10.1016/j.sajb.2019.08.024
dc.identifier.uri https://hdl.handle.net/20.500.14720/11517
dc.identifier.volume 125 en_US
dc.identifier.wos WOS:000488195200059
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Gundelia Rosea en_US
dc.subject 4-Caffeoylquinic Acid en_US
dc.subject Fatty Acids en_US
dc.subject Biopharmaceuticals en_US
dc.title Gundelia Rosea Seed: Evaluation of Biopharmaceutical Potential and Bioactive Composition en_US
dc.type Article en_US

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