The Effect of Short-Course High-Dose Methylprednisolone on Peripheral Blood Cd34+ Progenitor Cells of Children With Acute Leukemia During Remission Induction Therapy
dc.contributor.author | Tunç, B | |
dc.contributor.author | Öner, AF | |
dc.contributor.author | Hiçsönmez, G | |
dc.date.accessioned | 2025-05-10T16:59:05Z | |
dc.date.available | 2025-05-10T16:59:05Z | |
dc.date.issued | 2002 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | Suleyman Demirel Univ, Fac Med, Dept Pediat, Isparta, Turkey; Yuzuncu Yil Univ, Dept Pediat, Fac Med, Van, Turkey; Univ Hacettepe, Fac Med, Dept Pediat, TR-06100 Ankara, Turkey | en_US |
dc.description.abstract | This study was undertaken to determine the effect of short-course high-dose methylprednisolone (HDMP) treatment on peripheral blood (PB) CD34(+) progenitor cells during remission induction treatment in 11 children with newly diagnosed acute leukemia (7 with ALL, 4 with AML) whose bone marrow (BM) cells expressed fewer than 5% CD34 at the time of diagnosis. All children who had no infection were given HDMP as a single daily oral dose of 30 mg/kg for the first four days of induction therapy. The number of CD34(+) progenitor cells were determined by flow cytometry before and after four days of HDMP treatment. While the number of PB blast cells significantly decreased after only a four-day course of HDMP treatment, the number of PB CD34(+) progenitor cells increased in all patients. In addition, after four days of HDMP treatment polymorphonuclear leukocytes (PMN) and mononuclear cells (MNC) increased significantly (p < 0.05). We suggest that the potential beneficial effects of HDMP in the induction treatment of acute leukemia may occur partly by the stimulation of PB CD34(+) hematopoietic progenitor cells in a short period of time. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.endpage | 4 | en_US |
dc.identifier.issn | 0041-4301 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 11858371 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 1 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/4494 | |
dc.identifier.volume | 44 | en_US |
dc.identifier.wos | WOS:000173860500001 | |
dc.identifier.wosquality | Q4 | |
dc.language.iso | en | en_US |
dc.publisher | Turkish J Pediatrics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | High-Dose Methylprednisolone | en_US |
dc.subject | Children | en_US |
dc.subject | Acute Leukemia | en_US |
dc.subject | Cd34(+) Progenitor Cells | en_US |
dc.title | The Effect of Short-Course High-Dose Methylprednisolone on Peripheral Blood Cd34+ Progenitor Cells of Children With Acute Leukemia During Remission Induction Therapy | en_US |
dc.type | Article | en_US |