YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

The Effect of Short-Course High-Dose Methylprednisolone on Peripheral Blood Cd34+ Progenitor Cells of Children With Acute Leukemia During Remission Induction Therapy

dc.contributor.author Tunç, B
dc.contributor.author Öner, AF
dc.contributor.author Hiçsönmez, G
dc.date.accessioned 2025-05-10T16:59:05Z
dc.date.available 2025-05-10T16:59:05Z
dc.date.issued 2002
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Suleyman Demirel Univ, Fac Med, Dept Pediat, Isparta, Turkey; Yuzuncu Yil Univ, Dept Pediat, Fac Med, Van, Turkey; Univ Hacettepe, Fac Med, Dept Pediat, TR-06100 Ankara, Turkey en_US
dc.description.abstract This study was undertaken to determine the effect of short-course high-dose methylprednisolone (HDMP) treatment on peripheral blood (PB) CD34(+) progenitor cells during remission induction treatment in 11 children with newly diagnosed acute leukemia (7 with ALL, 4 with AML) whose bone marrow (BM) cells expressed fewer than 5% CD34 at the time of diagnosis. All children who had no infection were given HDMP as a single daily oral dose of 30 mg/kg for the first four days of induction therapy. The number of CD34(+) progenitor cells were determined by flow cytometry before and after four days of HDMP treatment. While the number of PB blast cells significantly decreased after only a four-day course of HDMP treatment, the number of PB CD34(+) progenitor cells increased in all patients. In addition, after four days of HDMP treatment polymorphonuclear leukocytes (PMN) and mononuclear cells (MNC) increased significantly (p < 0.05). We suggest that the potential beneficial effects of HDMP in the induction treatment of acute leukemia may occur partly by the stimulation of PB CD34(+) hematopoietic progenitor cells in a short period of time. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.endpage 4 en_US
dc.identifier.issn 0041-4301
dc.identifier.issue 1 en_US
dc.identifier.pmid 11858371
dc.identifier.scopusquality Q3
dc.identifier.startpage 1 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14720/4494
dc.identifier.volume 44 en_US
dc.identifier.wos WOS:000173860500001
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Turkish J Pediatrics en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject High-Dose Methylprednisolone en_US
dc.subject Children en_US
dc.subject Acute Leukemia en_US
dc.subject Cd34(+) Progenitor Cells en_US
dc.title The Effect of Short-Course High-Dose Methylprednisolone on Peripheral Blood Cd34+ Progenitor Cells of Children With Acute Leukemia During Remission Induction Therapy en_US
dc.type Article en_US

Files